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Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin

Lee JE, Jang H, Cho EJ, Youn HD

Down syndrome critical region 1 (DSCR1), an oxidative stress-response gene, interacts with calcineurin and represses its phosphatase activity. Recently it was shown that hydrogen peroxide inactivates calcineurin by proteolytic cleavage....
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A Pilot Study of Calcineurin Inhibitors (CNIs) and Steroid Avoidance Immunosuppressive Protocol among Living Donor Kidney Transplant Recipients

Oh HK, Ding P, Satmary NA

Calcineurin Inhibitors (CNIs) and Corticosteroids have been the main immunosuppressive agents in solid organ transplantation. Many studies have confirmed the positive impacts of withdrawal/avoidance of these agents, separately, on their...
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Induction of fibronectin gene expression by inhibitors of protein phosphatase type 2B in normal and transformed fibroblasts

Rhew JH, Shin YA, Lee BH, Park RW, Kim IS

  • KMID: 1029934
  • Exp Mol Med.
  • 1999 Jun;31(2):71-75.
Two intracellular signal pathways mediated by cAMP and protein kinase C (PKC) were involved in the regulation of FN gene expression (Lee et al., Exp. Mol. Med. 30: 240, 1998). In this...
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