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Sinensetin Inhibits Interleukin-6 in Human Mast Cell - 1 Via Signal Transducers and Activators of the Transcription 3 (STAT3) and Nuclear Factor Kappa B (NF-κB) Pathways

Chae HS, Kim YM, Chin YW

Sinensetin, a pentamethoxyflavone, is known to exert various pharmacological activities including anti-angiogenesis, anti-diabetic and anti-inflammatory activities. However, its effects on the human mast cell - 1 (HMC-1) mediated inflammatory mechanism...
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Mitochondrial calcium uniporter inhibition attenuates mouse bone marrow-derived mast cell degranulation induced by beta-1,3-glucan

Cuong DV, Kim HK, Marquez J, Kim N, Ko KS, Rhee BD, Han J

Mast cells are primary mediators of allergic inflammation. Beta-1,3-glucan (BG) protects against infection and shock by activating immune cells. Activation of the BG receptor induces an increase in intracellular Ca2+,...
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Swiprosin-1 Expression Is Up-Regulated through Protein Kinase C-theta and NF-kappaB Pathway in T Cells

Kim YD, Kwon MS, Na BR, Kim HR, Lee HS, Jun CD

Swiprosin-1 exhibits the highest expression in CD8+ T cells and immature B cells and has been proposed to play a role in lymphocyte biology through actin remodeling. However, regulation of...
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Emodin Isolated from Polygoni cuspidati Radix Inhibits TNF-alpha and IL-6 Release by Blockading NF-kappaB and MAP Kinase Pathways in Mast Cells Stimulated with PMA Plus A23187

Lu Y, Jeong YT, Li X, Kim MJ, Park PH, Hwang SL, Son JK, Chang HW

  • KMID: 2170660
  • Biomol Ther.
  • 2013 Nov;21(6):435-441.
Emodin, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, has several beneficial pharmacologic effects, which include anti-cancer, anti-diabetic, and anti-inflammatory activities. In this study, the authors examined the...
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Rapid Disruption of Cellular Integrity of Zinc-treated Astroglia Is Regulated by p38 MAPK and Ca(2+)-dependent Mechanisms

Im JY, Joo HJ, Han PL

Cultured cortical primary astroglia treated with zinc died while rapidly detached from culture plates, a distinct part of zinc-treated astroglia. In the present study, we investigated the mechanism underlying the...
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Transglutaminase 2 inhibits apoptosis induced by calciumoverload through down-regulation of Bax

Cho SY, Lee JH, Bae HD, Jeong EM, Jang GY, Kim CW, Shin DM, Jeon JH, Kim IG

An abrupt increase of intracellular Ca2+ is observed in cells under hypoxic or oxidatively stressed conditions. The dysregulated increase of cytosolic Ca2+ triggers apoptotic cell death through mitochondrial swelling and...
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Calcium-influx increases SOD1 aggregates via nitric oxide in cultured motor neurons

Kim HJ, Im W, Kim S, Kim SH, Sung JJ, Kim M, Lee KW

  • KMID: 1090960
  • Exp Mol Med.
  • 2007 Oct;39(5):574-582.
Familial amyotrophic lateral sclerosis (fALS) is caused by mutations in Cu/Zn-superoxide dismutase (SOD1), and SOD1 aggregation and calcium toxicity are involved in neuronal death. However, the effect of altered calcium...
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HO-1 Mediates Intracellular Calcium Modulation and Inhibits TNF-alpha-induced NF-kappaB Activity in Human Colonic Epithelial Cell Line

Kim YR, Jang SJ

  • KMID: 2092882
  • Korean J Anat.
  • 2006 Oct;39(5):401-406.
Heme oxygenage-1 (HO-1) is the rate-limiting enzyme in heme catabolism, which leads to the generation of carbon monoxide (CO), biliverdin, and free iron. HO-1 has been known to show strong immunosuppressive properties...
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Concanavalin A Mediated Calcium Changes on Expansion and Hatching of the Mouse Blastocyst

Cheon YP

  • KMID: 1772294
  • Korean J Fertil Steril.
  • 2005 Dec;32(4):337-346.
OBJECTIVE: The oligosaccharide moieties of glycoproteins and proteoglycans have a vital function in blastocyst differentiation. Concanavalin (ConA), a lectin, is known to bind on the preimplantation embryos, especially on blastocyst....
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Involvement of throm box aneA2 and tyrosine kinase in the synergistic interaction of platelet activating factor and calcium ionophore A23187 in human platelet aggregation

Rasheed H, Saeed SA

  • KMID: 1097103
  • Exp Mol Med.
  • 2004 Jun;36(3):220-225.
The present study was carried out to examine the mechanisms of the synergistic interaction of PAF and A23187 mediated platelet aggregation. We found that platelet aggregation mediated by subthreshold concentrations...
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Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A2 and 12-PGJ2.

Ahn SG, Kim HS, Jeong SW, Kim BE, Rhim HS, Shim JY, Kim JW, Lee JH, Kim IK

  • KMID: 1380233
  • Exp Mol Med.
  • 2002 Jul;34(3):243-249.
We reported earlier that expression of Sox-4 was found to be elevated during prostaglandin (PG) A2 and delta(12)-PGJ(12) induced apoptosis in human hepatocarcinoma Hep3B cells. In this study, the role...
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Analysis of Calcium-Binding Proteins of Mouse Spermatozoa by 2-Dimentional SDS-PAGE

Gye MC

  • KMID: 1573710
  • Korean J Androl.
  • 2000 Aug;18(2):105-109.
PURPOSE: To verify the expression of calcium-binding proteins in mouse spermatozoa. MATERIALS AND METHODS: Mouse sperm proteins were subjected to 2-dimentional SDS-PAGE combined with calcium shift in the presence or absence...
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Attenuation of endothelial relaxation in umbilical arteries from preeclampsia patients

Kim SK, Choi HM, Park YW, Kim JW, Ahn DS, Kang BS

  • KMID: 2261983
  • Korean J Obstet Gynecol.
  • 2000 Jun;43(6):1043-1050.
OBJECTIVES AND METHODS: To directly examine the function of the endothelial cell(EC) and smooth muscle cell in umbilical arteries acquired from preeclampsia patients between June 1998 to November 1999, using a...
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Observation of the Incidence of Acrosome Reaction in Human Spermatozoa Treated with Mibefradil as a T-type Ca2+i Channels Inhibitor

Lee JH, Lee IS, Kim YC, Son WY, Lee JH, Han CT

  • KMID: 2235708
  • Korean J Fertil Steril.
  • 2000 Mar;27(1):9-14.
OBJECTIVE : The sperm acrosome reaction is a Ca2+ -dependent exocytotic event that is triggered by adhesion to the mammalian egg's zona pellucida. Previous studies suggested a role of Ca2+...
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Relaxant effect of 4-aminopyridine on the mesenteric artery of rat

Kim SH, Lee TI

  • KMID: 1581024
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):463-469.
It has been well known that 4-aminopyridine (4-AP) has an excitatory effect on vascular smooth muscle due to causing membrane depolarization by blocking K+-channel. However, we observed that 4-AP had an inhibitory effect...
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Influence of conventional house-dust-mite immunotherapy on histamine releasability from the basophil

Shim JY, Kim BS, Cho SH, Min KU, Hong SJ

  • KMID: 2054868
  • J Asthma Allergy Clin Immunol.
  • 2000 Oct;20(5):731-740.
BACKGROUND: Allergen-specific immunotherapy has been shown to be clinically effective in the treatment of patients with atopic asthma, but the mechanisms are still unclear. Some of the immunologic changes include...
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The Effect of Activation of Protein Kinase C on the Calcium-dependent K; Current in Rat Basilar Smooth Muscle Cells

Kim CJ

  • KMID: 1956074
  • J Korean Neurosurg Soc.
  • 1999 Sep;28(9):1272-1281.
OBJECTIVE: Activation of protein kinase C(PKC) may play a certain role in the development of cerebral vasospasm. However, this mechanism still elusive. This study was undertaken to investigate the action...
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Effect of imipramine on calcium utilization of single cells isolated from canine detruso

Shim HS, Choi HC, Jeong YS, Kim JH, Lee KY, Sohn UD, Ha JH, Kim WJ

  • KMID: 1554061
  • Korean J Physiol Pharmacol.
  • 1999 Aug;3(4):439-445.
This study is to investigate the mechanism of inhibitory effect of imipramine on the calcium utilization in single cells isolated from canine detrusor. 2 mm thick smooth muscle chops were incubated in...
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Comparison of basophil histamine releasability between atopic and nonatopic thmatics

Son JW, Kim YK, Chung JW, Lee SR, Cho SH, Min KU, Koh YY, Kim YY

To compare the mediator releasability between atopic and nonatopic asthmatics, we measured basophil histamine releasability (BaHR) using a calcium-ionophore A23187 and anti-IgE in 137 subjects who were treated at Seoul...
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A Study on Apoptosis of HGPRT- Mouse Myeloma Cell Induced by Aminopterin, a de novo Pathway Blocking Agent

Choi Y, Chung YH

  • KMID: 1550793
  • Korean J Immunol.
  • 1999 Mar;21(1):25-34.
Programmed cell death (PCD), or apoptosis, plays an important role in embryonic development, metamorphsis, hormone-dependent atrophy and tumor growth, as a physiological event regulating the cell number or eliminating damaged...
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