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Vitamin D maintains E-cadherin intercellular junctions by downregulating MMP-9 production in human gingival keratinocytes treated by TNF-α

Oh C, Kim HJ, Kim HM

PURPOSE: Despite the well-known anti-inflammatory effects of vitamin D in periodontal health, its mechanism has not been fully elucidated. In the present study, the effect of vitamin D on strengthening...
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Role of E-cadherin and cyclin D1 as predictive markers of aggression and clonal expansion in head and neck squamous cell carcinoma

Shergill K, Sen A, Pillai HJ

OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Inconsistency in various histopathologic features for predicting nodal metastasis and overall prognosis and a better...
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Substrate roughness induces the development of defective E-cadherin junctions in human gingival keratinocytes

Jin C, Lee G, Oh C, Kim HJ, Kim HM

PURPOSE: The entry of bacteria or harmful substances through the epithelial seal of human gingival keratinocytes (HGKs) in the junctional epithelium (JE) is blocked by specialized intercellular junctions such as...
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Clinicopathologic Correlations of E-cadherin and Prrx-1 Expression Loss in Hepatocellular Carcinoma

Yi K, Kim H, Chung Y, Ahn H, Sim J, Wi YC, Pyo JY, Song YS, Paik SS, Oh YH

BACKGROUND: Developing predictive markers for hepatocellular carcinoma (HCC) is important, because many patients experience recurrence and metastasis. Epithelial to mesenchymal transition (EMT) is a developmental process that plays an important...
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The Epithelial-Mesenchymal Transition and E-cadherin and Vimentin Expression in Basal Cell Carcinoma and Squamous Cell Carcinoma

Kim YU, Kim KJ, Heo EP

  • KMID: 2246223
  • Korean J Dermatol.
  • 2015 Feb;53(2):96-105.
BACKGROUND: The epithelial-mesenchymal transition (EMT) in epithelial tumor cells plays a key role in tumor invasion and metastasis. The reduction or loss of E-cadherin and the acquisition of vimentin are...
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Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors

Kim JH, Choi KY, Lee DJ, Rho YS, Jo SJ

  • KMID: 2278408
  • Clin Exp Otorhinolaryngol.
  • 2014 Mar;7(1):53-58.
OBJECTIVES: To evaluate the loss of heterozygosities (LOH) of chromosomes 3p14 (FHIT gene), 9p21 (p16), 13q21 (pRb), 6q22 (E-cadherin) and 17p13 (p53) in various thyroid tumors. METHODS: Eighty thyroid tumor cases...
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Effect of Puromycin Aminonucleoside on Podocyte P-Cadherin

Ha TS

  • KMID: 2098914
  • J Korean Soc Pediatr Nephrol.
  • 2013 Oct;17(2):79-85.
PURPOSE: To test whether the expression of P-cadherin, a component of slit diaphragms between podocyte foot processes, would be altered by puromycin aminonucleoside (PAN) in a cultured podocyte in vitro. METHODS:...
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Bacteroides fragilis Toxin Induces IL-8 Secretion in HT29/C1 Cells through Disruption of E-cadherin Junctions

Hwang S, Gwon SY, Kim MS, Lee S, Rhee KJ

Enterotoxigenic Bacteroides fragilis (ETBF) is a human gut commensal bacteria that causes inflammatory diarrhea and colitis. ETBF also promotes colorectal tumorigenesis in the Min mouse model. The key virulence factor...
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Correlation of Decreased Expressions of Claudin 4 and E-cadherin Proteins and the Clinicopathologic Factors of Stomach Cancer

Lee SM, Lee JH, Kim BG, Kim YS, Park YG, Chi KC, Lim HM, Kim SJ

  • KMID: 2211100
  • J Korean Surg Soc.
  • 2007 Sep;73(3):221-226.
PURPOSE: We examined the expressions of claudin-4 and E-cadherin, which are known as cell adhesion-associated proteins, in stomach cancer. The relationship of their expression with the clinicopathologic factors was examined...
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Relation of the E-cadherin Expression and the Lauren Classification in Stomach Cancer according to the Tumor Location

Jun KH, Won YS, Na GH, Suh YJ, Cho HM, Park WB, Chin HM, Chun CS

  • KMID: 2117087
  • J Korean Surg Soc.
  • 2007 Nov;73(5):392-399.
PURPOSE: E-cadherin (ECD) plays a pivotal role in integrating the normal tissue architecture and the suppression of cancer invasion, including stomach cancer. The epidemiology of stomach cancers is noticeably different...
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The Effect of Cyclosporine on P-cadherin Expression in Experimental Diabetic Nephropathy and Glucose-Stimulated Podocytes

Kang SW, Yoo TH, Kim HJ, Choi HY, Kim JS, Jung DS, Kim JJ, Kwak SJ, Han SH, Kim DK, Lee TH, Lee JE, Han DS, Ryu DR

  • KMID: 2254127
  • Korean J Nephrol.
  • 2007 Jan;26(1):23-33.
PURPOSE: We investigated whether Cyclosporin A (CsA) had the anti-proteinuric effect in diabetic rats and whether it was associated with the alteration of P-cadherin expression. METHODS: Sprague-Dawley rats were injected with...
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Expression of e-cadherin and beta-catenin in relation to clinicopathologic features in oral squamous cell carcinoma

Pyo SW, Lee KB, Kim YS, Lee SH

  • KMID: 2058617
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2006 Sep;28(5):396-403.
Changes in cell adhesion molecules are associated with infiltration and metastatic progression of cancer. Reduced expression of E-cadherin and beta-catenin complex in some carcinomas has been reported. The changes in...
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Biologic behavior of E-cadherin in Invasive Ductal Carcinoma of the Breast

Lee SG, Bae JW, Kim JH, Chae YS, Cho KR, Lee JB, Son GS, Koo BH

PURPOSE : E-cadherin is a tumor suppressor adhesion molecule that has an anti-invasive role and it is often considered as a useful marker for differentiating the lobular types from the...
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Expression of E-cadherin in pT2 Lesion of Gastric Cancer

Yang WY, Koo BU, Yun HY, Ryu DH, Song YJ, Kim SH, Eom SY, Kim H

  • KMID: 1940503
  • J Korean Surg Soc.
  • 2006 Feb;70(2):91-97.
PURPOSE: Abnormal expression of E-cadherin has been shown to play a role in the progression and the metastasis of tumors. We investigated the correlation between the expressions of E-cadherin and...
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C-met and E-cadherin Expression in Advanced Gastric Cancer

Oh ST, Lee YD, Hwang YJ, Suh JH, Lee WK

  • KMID: 1940533
  • J Korean Surg Soc.
  • 2005 Sep;69(3):210-216.
PURPOSE: In the current study, the relation between the clinicopathological parameters and levels of the amplification of the c-met and E-cadherin genes were investigated in patients with an advanced gastric...
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Expression of Actin-bundling Protein Fascin and its Relationship with Altered E-cadherin and beta-catenin Expressions in Ovarian Serous Neoplasms

Cho EY, Choi Y, Chae SW, Kim EJ, Kim K, Ahn GH, Sohn JH

  • KMID: 1855948
  • Korean J Pathol.
  • 2005 Aug;39(4):258-264.
Background : Fascin, an actin-bundling protein, has been found in specialized normal cells, including the neuronal, endothelial and dendritic cells, and its expression is known to be greatly increased in...
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Expression of Osteopontin, ZO-1 and E-cadherin in Adenoma and Adenocarcinoma of the Colon

Jeong YK, Lee MJ, Lim SC, Kee KH, Jeon HJ, Suh CH

  • KMID: 1855946
  • Korean J Pathol.
  • 2005 Aug;39(4):242-250.
Background : The expressions of osteopontin (OPN), zonula occludens-1 (ZO-1) and E-cadherin, known as cell adhesion-associated substances, were examined in adenoma and adenocarcinoma of the colon. The relationship of their...
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E-cadherin Expression Loss in T1 Invasive Ductal Carcinoma of the Breast as a Predictive Marker for Lymph Node Metastasis

Kim EK, Sahin A

  • KMID: 1598095
  • Korean J Pathol.
  • 2005 Jun;39(3):187-191.
BACKGROUND: E-cadherin is a transmembrane glycoprotein, which has been shown to mediate calcium-dependent epithelial cell adhesion. A loss of E-cadherin expression has been associated with the tumor invasion and metastatic...
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Expression of E-cadherin and Catenin (alpha-, beta-catenin) in Endometrial Cancer and Atypical Complex Endometrial Hyperplasia

Yang YJ, Lee HJ, Lee KH, Lee YY, Jang ED, Lee JW, Namkoong S, Park TC

  • KMID: 1594567
  • Korean J Obstet Gynecol.
  • 2005 Jun;48(6):1456-1465.
OBJECTIVE: To evaluate the correlation of the expression of E-cadherin, alpha-catenin, beta-catenin and the clinicopathological features in endometrial cancer (EC) and atypical complex endometrial hyperplasia (ACEH). METHODS: Immunohistochemical (IHC) staining...
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Expression of e-cadherin with correlation to clinicopathologic parameters in oral squamous cell carcinoma

Shin JM, Kim YS, Kim CH, Pyo SW

  • KMID: 2058807
  • J Korean Assoc Oral Maxillofac Surg.
  • 2005 Feb;31(1):1-6.
It becomes more concerned that the cell adhesion molecule plays an important role in the process of malignant transformation and tumor behaviors including invasive growth and metastasis. It is postulated...
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