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Word Embedding Reveals Cyfra 21-1 as a Biomarker for Chronic Obstructive Pulmonary Disease

Heo J, Moon DH, Hong Y, Bak SH, Kim J, Park JH, Oh BD, Kim YS, Kim WJ

Background: Although patients with chronic obstructive pulmonary disease (COPD) experience high morbidity and mortality worldwide, few biomarkers are available for COPD. Here, we analyzed potential biomarkers for the diagnosis of COPD...
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Diagnostic Significance of the Ratio of Plasma CYFRA 21-1 Autoantibody Immune Complex to Free CYFRA 21-1 in Patients with Colon Cancer

Choi HW, Kim H, Oh Ac, Lee JK, Hong YJ

Background: The use of plasma autoantibodies associated with cancer as tumor biomarkers has been studied for several decades. We investigated the diagnostic significance of the ratio of CYFRA 21-1-anti-CYFRA 21-1...
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Performances of CYFRA 21-1, Carcinoembryonic Antigen and Their Combination for Lung Cancer Diagnosis

Kim JJ, Ahn HJ, Park Y

BACKGROUND: The aim of this study was to compare the efficiency of cytokeratin 19 fragment (CYFRA 21-1) and carcinoembryonic antigen (CEA) for the diagnosis of lung cancer and to establish...
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Cerebrospinal Fluid CYFRA 21-1 as a Diagnostic Indicator for Leptomeningeal Metastasis in Cancer Patients

Hyun JW, Kim S, Shin HS, Yun JY, Kim SY, Kim SH, Kim JK, Jeong JH, Yoo H, Gwak HS, Kim HJ

BACKGROUND: The early and accurate diagnosis of leptomeningeal metastasis (LM) has become important because of introduction of new therapeutic strategies for LM and increasing incidence of LM along with longer...
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Diagnostic Utility of Serum Cytokeratin Fragment 21-1 in Patients with Lung Cancer

Song S, Yoo EH, Cho HJ

BACKGROUND: Lung cancer is the most lethal malignant neoplasm in the world. Serum cytokeratin fragment 21-1 (Cyfra 21-1) is a valuable tumor marker for detection of lung cancer, and it...
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Clinical Usefulness of Serum CYFRA 21-1 in Patients with Colorectal Cancer

Lee JH

  • KMID: 2313148
  • Nucl Med Mol Imaging.
  • 2013 Sep;47(3):181-187.
PURPOSE: Among diverse tumor markers, pretreatment evaluation and follow-up detection of recurrence in colorectal cancer are generally evaluated by serum carcinoembryonic antigen (CEA) levels. However, there have been some reports...
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Pathologic Correlation of Serum Carcinoembryonic Antigen and Cytokeratin 19 Fragment in Resected Nonsmall Cell Lung Cancer

Lee S, Lee CY, Kim DJ, Hong DJ, Lee JG, Chung KY

BACKGROUND: This study focused on the association between preoperative serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (Cyfra 21-1) levels and pathologic parameters in patients with resected non-small-cell lung cancer...
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Prognostic and Predictive Value of Carcinoembryonic Antigen and Cytokeratin-19 Fragments Levels in Advanced Non-Small Cell Lung Cancer Patients Treated with Gefitinib or Erlotinib

Jung M, Kim SH, Hong S, Kang YA, Kim SK, Chang J, Rha SY, Kim JH, Kim DJ, Cho BC

  • KMID: 2453950
  • Yonsei Med J.
  • 2012 Sep;53(5):931-939.
PURPOSE: The prognostic and predictive value of pretreatment serum levels of carcinoembryonic antigen (CEA) and cytokeratin-19 fragments (CYFRA 21-1) were assessed in advanced non-small cell lung cancer (NSCLC) patients treated...
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The CT Findings and the Peak SUV on PET/CT according to the Levels of Cyfra 21-1 and CEA in Patients with Non-Small Cell Lung Carcinoma

Jou SS, Park JS, Kim YT, Hwang JH, Park JM, Han JK, Kim HH

PURPOSE: We wanted to evaluate the CT findings and the peak SUV according to the levels of cyfra 21-1 and CEA in patients with non-small cell lung carcinoma (NSCLC). MATERIALS AND...
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Clinical Effectiveness of Tumor Markers (CEA, NSE, Cyfra 21-1) in Completely Resected Non-small Cell Lung Cancer

Haam SJ, Kim GD, Cho SH, Lee DY

PURPOSE: The applicability of tumor markers still remains controversial in non-small cell lung cancer (NSCLC) due to lower sensitivity & specificity. And, tumor markers actually have not been used determining...
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Relationship between Pre-treatment Serum SCC (squamous cell carcinoma) Antigen, Cyfra 21-1 Levels, and Survival in Squamous Cell Carcinoma of the Uterine Cervix

Chang KH, Ryu HS, Chang SJ, Byun YJ, Lee JP

  • KMID: 2166120
  • Cancer Res Treat.
  • 2005 Oct;37(5):302-306.
PURPOSE: To determine the relationship between pretreatment serum squamous cell carcinoma (SCC) antigen and Cyfra 21-1 levels, and survival in patients with invasive squamous cell carcinoma of the cervix. MATERIALS...
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Diagnostic Utility of Pleural Fluid CEA and CYFRA 21-1 for Malignant Pleural Effusions

Chung JH, Choi JE, Park MS, Hwang SY, Moon JW, Kim YS, Chang J, Kim JH, Kim SK, Kim SK

  • KMID: 2318487
  • Tuberc Respir Dis.
  • 2004 Jul;57(1):32-36.
BACKGROUND: The purpose of this study was to evaluate the usefulness of the pleural fluid carcinoembryonic antigen (CEA) and cytokeratin fragment 19 (CYFRA 21-1) tumor markers as complementary tools for...
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Diagnostic Value of Serum Cytokeratin 8, 18 and 19 in Lung Cancer

Choi CM, Kim WJ, Oh JY, Kang YA, Yoo CG, Lee CT, Kim YW, Han SK, Shim YS

  • KMID: 2318434
  • Tuberc Respir Dis.
  • 2003 Oct;55(4):388-394.
BACKGROUND: Monoclonal antibodies directed against well-known epitopes on cytokeratin (CK) 8, 18 and 19 (Monototal) have been used in the development of a new diagnostic tool for lung cancer. In...
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Usefulness of cyfra 21-1 as a tumor marker of lung cancer

Park HD, Jeong HS, Park JS, Lim SH, Lee EJ, Yun JW, Jung SS, Shin HC, Lee SS

  • KMID: 2252889
  • Korean J Med.
  • 2002 Apr;62(4):415-421.
BACKGROUND: Cytokeratins are epithelial markers whose expressions are not lost during malignant transformation. The utility of cytokeratin fragment (Cyfra) 21-1, a new tumor marker, was investigated in 110 patients with...
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Diagnostic Value of Cyfra 21-1 in Differential Diagnosis of Pleural Effusion

Lee HJ, Lee KH, Shin KC, Shin CJ, Park HJ, Mun YC, Lee KH, Chung JH, Hyun MS, Lee HW

BACKGROUND: Pleural effusion is a common clinical problem and many clinical and laboratory evaluations, such as tumor marks, have been studied to discriminate malignant pleural fluid from benign pleural fluid....
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Clinical value of pretreatment serum cyfra 21-1 and SCC Ag levels in cervical cancer patients

Oh KS, Chung TY, Chung DY, Ryu HS, Chang KH, Chun MS, Park CH, Park YH

  • KMID: 2261601
  • Korean J Obstet Gynecol.
  • 1999 Dec;42(12):2720-2725.
OBJECTIVES: SCC Ag(Squamous cell carcinoma antigen) is so far the most useful tumor marker in assisting clinical diagnosis of cervical cancer and follow-up after therapy. Elevated levels of cytokeratin 19-fragments(CYFRA...
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Clinical Significance of Adenosine Deaminase and CYFRA 21-1 in the Differential Diagnosis of Tuberculous and Malignant Pleural Effusion

Hwang JH, Jang IG, Kim YI, Park HK, Lim SC, Kim YC, Park KO

  • KMID: 2172512
  • Chonnam Med J.
  • 1998 Jun;34(1):19-29.
BACKGROUND: The differentiation of tuberculous pleural effusion from the other causes of exudative pleural effusion remained difficult even with aids of biochemical analyses and pleural biopsy. CYFRA 21-1 is a...
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Analysis of Specificity for Tumor Marker CYFRA 21-1 in Patients with Pulmonary Tuberculosis

Ha HC, Lee JS, Song SD, Kim CM, Lee MG, Kim IJ

  • KMID: 2318133
  • Tuberc Respir Dis.
  • 1998 Apr;45(2):290-300.
BACKGROUND: CYFRA 21-1 is a tumor marker which measures a fragment of cytokeratin 19 expressed by epithelial cells in bronchus. It is known that cytokeratin 19 is abundant in squamous...
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Diagnostic Value of Serum CYFRA 21-1 in Lung Cancer

Yoon HD, Kim KD, Chung JH, Lee HW, Lee KH, Lee HW, Cho IH

  • KMID: 2317894
  • Tuberc Respir Dis.
  • 1995 Apr;42(2):149-155.
BACKGROUND: Cytokeratin 19 is 40KD acidic molecule whose distribution is restricted to simple or pseudo-stratified epithelia, such as the epithelial layer of the bronchial tree. Immunohistochemical study have shown that...
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Diagnostic Usefulness of Serum Level of Cyfra 21-1, SCC Antigen and CEA in Lung Cancer

Kim K, Lee MH, Koh Y, Kim SH, Lim CM, Lee SD, Kim WS, Kim DS, Kim WD, Moon DH

  • KMID: 2317953
  • Tuberc Respir Dis.
  • 1995 Dec;42(6):846-854.
BACKGROUND: Cytokeratin 19 is a subunit of cytokeratin intermediate filament expressed in simple epithelia such as respiratory epithelial cells and their malignant counterparts. An immu- noradiometric assay is available to...
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