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A case of autoimmune enteropathy with CTLA4 haploinsufficiency

Miyazaki H, Hoshi N, Kohashi M, Tokunaga E, Ku Y, Takenaka H, Ooi M, Yamamoto N, Uemura S, Nishimura N, Iijima K, Jimbo K, Okano T, Hoshino A, Imai K, Kanegane H, Kobayashi I, Kodama Y

Autoimmune enteropathy (AIE) is a rare disease, characterized by intractable diarrhea, villous atrophy of the small intestine, and the presence of circulating anti-enterocyte autoantibodies. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX)...
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Melanoma Cell Death Mechanisms

Broussard , Howland A, Ryu S, Song K, Norris D, Armstrong , Song PI

Over recent years, several new molecular and immunogenic therapeutic approaches to melanoma treatment have been approved and implemented in clinical practice. Mechanisms of resistance to these new therapies have become...
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Association Between Serum IgE Levels and the CTLA4 +49A/G and FCER1B -654C/T Polymorphisms in Korean Children With Asthma

Oh KY, Kang MJ, Choi WA, Kwon JW, Kim BJ, Yu J, Hong SJ

PURPOSE: T cells play a central role in cell-mediated immunity, atopic disease, and asthma. The balance of CD28/cytotoxic T-lymphocyte antigen 4 (CTLA4)-derived signal transduction plays an important role in the...
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New drugs for Rheumatoid arthritis

Seo YI

  • KMID: 2257380
  • Korean J Med.
  • 2009 Jan;76(1):12-17.
Since the late 1990s, based on scientific advancement and biotechnological improvement, many effective drugs such as leflunomide and biologic agents for rheumatoid arthritis (RA) have been developed. These include TNF-alpha...
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Human Cytotoxic T Lymphocyte-associated Antigen 4-immunoglobulin Fusion Protein Inhibits Airway Inflammation and Hyperresponsiveness in a Murine Model of Asthma

  • KMID: 2234531
  • Korean J Asthma Allergy Clin Immunol.
  • 2008 Sep;28(3):205-213.
BACKGROUND: CD4+ T helper cells which differentiate into the Th2 cells are crucial for the initiation and progression of allergic asthma. Human Cytotoxic T Lymphocyte- associated Antigen 4-immunoglobulin (CTLA4-Ig) has...
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IL-2 Pathway Blocking in Combination with Anti-CD154 Synergistically Establishes Mixed Macrochimerism with Limited Dose of Bone Marrow Cells and Prolongs Skin Graft Survival in Mice

Lee JH, Ha J, Kim SH, Kim SJ

To facilitate the establishment of mixed chimerism with limited dose of bone marrow (BM) cells, and to achieve tolerance in skin graft model, combined blocking of costimulatory pathway and IL-2...
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Inhibitory effects of CTLA4-Ig fusion protein on the proliferation of T cell and the antibody production of B cell

Jang SO, Lee SY, Hong SJ

  • KMID: 2178421
  • J Asthma Allergy Clin Immunol.
  • 2003 Dec;23(4):818-825.
BACKGROUND: Atopic asthma is characterized by activation of Th2-type T cells in the bronchial mucosa. Several reports have suggested an important role for costimulation through the CD28/CTLA4 (cytotoxic T lymphocyte-associated...
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Immunotherapeutic Effects of CTLA4Ig Fusion Protein on Murine EAE and GVHD

Jang SO, Hong SJ, Cho HS, Chung YH

BACKGROUND: CTLA4 (CD152), which is expressed on the surface of T cells following activation, has a much higher affinity for B7 molecules comparing to CD28, and is a negative regulator...
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Polymorphism of CTLA4 Gene in Schizophrenia

Kim YH, Jun TY, Pae CU, Lee CT

  • KMID: 2340642
  • J Korean Neuropsychiatr Assoc.
  • 2002 Jan;41(1):69-75.
OBJECT: This study was performed to examine the relationship between immunogenetics and schizophrenia by analyzing polymorphism of CTLA4 gene, which is known to affect the apoptosis and the activation of...
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