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Salicylate Regulates Cyclooxygenase-2 Expression through ERK and Subsequent NF-kappaB Activation in Osteoblasts

Chae HJ, Lee JK, Byun JO, Chae SW, Kim HR

  • KMID: 2285293
  • Korean J Physiol Pharmacol.
  • 2003 Aug;7(4):239-246.
The expression of cyclooxygenase-2 (COX-2) is a characteristic response to inflammation and can be inhibited with sodium salicylate. TNF-alpha plus IFN-gamma can induce extracellular signal-regulated kinase (ERK), IKK, IkappaB degradation...
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