- A Study of the Bystander Effect and Its Enhancement in HSV-TK Gene Therapy Using a Murine Neuroblastoma Model
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Cho HS, Kim MK, Park CY
- KMID: 2335600
- J Korean Pediatr Soc.
- 2002 Mar;45(3):354-361.
PURPOSE: Selective introduction of genes conferring chemosensitivity into proliferating tumor cells may be used to treat cancer. We first investigated the bystander effect of retrovirus-mediated gene transfer of herpes simplex... -
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- Increased Thymidine Kinase Activity and in vitro Bystander Effect by Double Transfer of HSVtk Gene into T98G Tumor Cells
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Kim YG
- KMID: 2188358
- J Korean Neurosurg Soc.
- 1999 Mar;28(3):293-299.
Transduction of retroviral-mediated herpes simplex virus thymidine kinase(HSVtk) gene into tumor cells and subsequent ganciclovir(GCV) treatment have been used as an experimental and clinical therapeutic strategy. Because non-transduced tumor cells... -
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- Bystander-Mediated Regression of Murine Neuroblastoma via Retroviral Transfer of the HSV-TK Gene
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Cho HS, Lee HR, Kim MK
- KMID: 1785703
- J Korean Med Sci.
- 2004 Feb;19(1):107-112.
- doi: 10.3346/jkms.2004.19.1.107
Selective introduction of genes conferring chemosensitivity into proliferating tumor cells may be used to treat cancer. We investigated the bystander effect of retrovirusmediated gene transfer of herpes simplex virus thymidine... -
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- Novel Gap Junction Molecules, Connexin 37, Enhances the Bystander Effect in HSVtk/GCV Gene Therapy
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Kim SY, Yi HK, Lee JC, Hwang DJ, Hwang PH, Lee DY, Cho SC
- KMID: 1606818
- J Korean Pediatr Soc.
- 2003 Jun;46(6):541-547.
PURPOSE: Gap junction intercellular communication(GJIC) is an important mechanism of the bystander effect in herpes simplex thymidine kinase/ganciclovir(HSVtk/GCV) gene therapy Therefore, we attempted to enhance the bystander effect in vitro... -
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- Effect of retinoic acid on the bystander effect in gene therapy using the Herpes Simplex Virus thymidine kinase
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Park JY, Kim CH, Jung TH, Albelda SM
- KMID: 2318020
- Tuberc Respir Dis.
- 1997 Feb;44(1):162-174.
BACKGROUND: Metabolic cooperation via gap junctional intercellular communication (GJIC) is an important mechanism of the bystander effect in gene therapy using the Herpes Simplex Virus thymidine kinase/ganciclovir (HSVtk) 'prodrug' system.... -
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- Combined Therapy of Gene Therapy using the Herpes Simplex Virus Thymidine Kinase, and Retinoic Acid
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Park JY, Albelda SM
- KMID: 2175469
- J Korean Cancer Assoc.
- 1997 Apr;29(2):321-331.
PURPOSE: Metabolic cooperation via gap junctional intercellular communication (GJIC) is an important mechanism of the bystander effect in gene therapy using the Herpes Simplex Virus thymidine kinase/ganciclovir (HSVtk/GCV) "prodrug" system.... -
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- Bystander Effect of HSV-TK/GCV Gene Therapy in Murine Neuroblastoma
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Shim EJ, Kim SR, Park EH, Cho HS, Cha JK, Lee HR
- KMID: 1829876
- J Korean Pediatr Soc.
- 2001 Nov;44(11):1249-1253.
PURPOSE: To demonstrate the bystander effect in murine neuroblastoma model which transduced with HSV-TK gene in vitro and in vivo. METHODS: The LNC/TK vector was transfered in vitro into the... -
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- Enhanced in vitro and in vivo Bystander Effect by Double Transfer of Herpes Simplex Virus Thymidine Kinase Gene
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Kim YG, Kim ST, Yoon HD
- KMID: 2188505
- J Korean Neurosurg Soc.
- 1999 Oct;28(10):1407-1417.
OBJECTIVE: The bystander effect, the phenomenon that non-transduced tumor cells can be killed along with the transduced cells, enables suicidal gene therapy feasible in spite of low efficiency of gene... -
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- Herpes Simplex virus thymidine kinase gene therapy delivered by retroviral or adenoviral vector in mouse model of lewis lung carcinoma
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Kwon HC, Jeong JM, Kim JH, Ham YH, Seo JS, Chang KH, Kim M, Lee HS, Lee CT
- KMID: 2160280
- Tuberc Respir Dis.
- 2000 Sep;49(3):298-309.
- doi: 10.4046/trd.2000.49.3.298
BACKGROUND: The antitumor effects of herpes simplex virus thymidine kinase(HSV-tk) and ganciclovir(GCV) strategies for cancer gene therapy have a the following advantages:1) a direct cytotoxicity to HSV-tk modified cancer cells... -
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- Comparison of Two Different Hepatoma cell Lines Expressing Herpes Simplex Virus Thymidine Kinase ( HSVtk ) on Their Semsotovotu and Bystander Effect of Ganciclovir (GCV )
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Suh EJ, Chung TW, Kim SH, Kim T, Park JB, Ryu YW, Lee CW
- KMID: 2329149
- J Korean Cancer Assoc.
- 1998 Jun;30(3):553-560.
No abstract available. -
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- Effect of Butyrate on Adenovirus-Mediated Herpes Simplex Virus Thymidine Kinase Gene Therapy
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Park JY, Kim JR, Chang HJ, Kim CH, Park JH, Jung TH
- KMID: 1969835
- Tuberc Respir Dis.
- 1998 Jun;45(3):587-595.
- doi: 10.4046/trd.1998.45.3.587
BACKGROUND: Recombinant adenovirus hold promise as vectors to carry therapeutic genes for several reasons: 1) they can infect both dividing and non-dividing cells ; 2) they have the ability to... -
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- Adenovirus-Mediated Thymidine Kinase Gene Transfer with Exposure of Ganciclovir to Uterine Cervical Cancer Cells
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Kim TE, Ro DY, Kim YW, Kim HK, Lee HS, Jung JK, Kim JW, Namkoong S
- KMID: 2143465
- Korean J Gynecol Oncol Colposc.
- 2003 Sep;14(3):195-201.
OBJECTIVE: Although herpes simplex virus thymidine kinase gene (HSVtk) transfer with ganciclovir (GCV) represents the commonly used suicide gene therapy of human cancers, little is known about the feasibility of... -
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- Gene Transfer Effects of Thymidine Kinase Gene of Herpes Simplex Type 1 on Ganciclovir Cytotoxicity in Gastric Cancer Cell Line
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Roh JK, Gong SJ, Kim JH, Um HD, Yoo NC, Choi JH, Song JJ, Rha SY, Chung HC, Min JS, Kim BS
- KMID: 2175424
- J Korean Cancer Assoc.
- 1998 Feb;30(1):20-30.
PURPOSE: Gastric cancer is the most common malignancy in Korea. Although treatment such as surgery, chemotherapy, and immunotherapy has greatly improved, the mortality rate of gastic cancer is... -
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- The Transfection of Cytosine Deaminase Gene and the Cell Killing Effects of Administration of 5-Fluorocytosine in Colon Cancer Cell Lines
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Cha SW, Chang SK
- KMID: 1896294
- J Korean Surg Soc.
- 2004 Apr;66(4):271-280.
PURPOSE: Among cancer gene therapies, the aims to eliminate malignant cells using genes as drugs as substitutes for conventional therapy, the use of bacterial cytosine deaminase (CD) which can convert... -
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- Suitability of autologous serum for expanding rabbit adipose-derived stem cell populations
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Bahn JJ, Chung JY, Im W, Kim M, Kim SH
- KMID: 2392000
- J Vet Sci.
- 2012 Dec;13(4):413-417.
Adipose-derived stem cells (ASCs) are believed to have potential use for treating many illnesses. Most cells, including ASCs, are generally cultured in medium containing fetal bovine serum (FBS). However, FBS,... -
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- Combination Gene Therapy of Herpes Simplex Virus Thymidine Kinase and Cytokines in Lung Cancer
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Kim G, Park KH, Seol JY, Yoo CG, Lee CT, Kim YW, Han SK, Shim YS
- KMID: 2318345
- Tuberc Respir Dis.
- 2001 Aug;51(2):135-146.
- doi: 10.4046/trd.2001.51.2.135
BACKGROUND: One of the important mechanisms responsible for a tumor escaping the immune response is an absence of the tumor associated antigen (TAA) on the cancer cell surface. To overcome... -
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- Transduction of yeast cytosine deaminase mediated by HIV-1 Tat basic domain into tumor cells induces chemosensitivity to 5-fluorocytosine
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Lee H, Ryu J, Kim KA, Lee KS, Lee JY, Park JB, Park J, Choi SY
- KMID: 755664
- Exp Mol Med.
- 2004 Feb;36(1):43-51.
Enzyme/prodrug approach is one of the actively developing areas for cancer therapy. In an effort to develop more effective enzyme/prodrug systems, cell-permeable cytosine deaminase was produced by fusing yeast cytosine... -
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