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Genomic Signatures from Clinical Tumor Sequencing in Patients with Breast Cancer Having Germline BRCA1/2 Mutation

Kim JW, Kang HE, Choi J, Yun SG, Jung SP, Bae SY, You JY, Choi YJ, Kim YH, Park KH

Purpose BRCA1 and BRCA2 are among the most important genes involved in DNA repair via homologous recombination (HR). Germline BRCA1/2 (gBRCA1/2)-related cancers have specific characteristics and treatment options but conducting gBRCA1/2...
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Factors Affecting Intensive Care Unit Nurses’ Care Burden of Patients with Hematologic Neoplasm

Lee J, Jeong DS, Jeon H, Kim JH, Kim DY

Purpose: This study was a descriptive study to identify the factors affecting nurses' care burden of patients with hematologic neoplasm (PHN) in the intensive care unit (ICU). Methods: A total...
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Disease burden and epidemiologic characteristics of injury in Korea

Jun S, Park H, Kim UJ, Park H

Background: Injury is a major public health concern because it is a major cause of death and may cause lifelong disabilities. New environmental risk factors, such as extreme climates, are...
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A Study on the Mitigation Methods of Financial Burden in Public Long-term Care Insurance System: Comparison of South Korea, Japan, and Germany

Yoon NY, Lee DH

The rapidly aging trend of Korea is a major factor that threatens the sustainability of the long-term care insurance system. Therefore, looking at how Japan and Germany mitigated the financial...
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The Feasibility of Using Biomarkers Derived from Circulating Tumor DNA Sequencing as Predictive Classifiers in Patients with Small-Cell Lung Cancer

Feng Y, Liu Y, Yuan M, Dong G, Zhang H, Zhang T, Chang L, Xia X, Li L, Zhu H, Xing P, Wang H, Shi Y, Wang Z, Hu X

Purpose To investigate the feasibility of biomarkers based on dynamic circulating tumor DNA (ctDNA) to classify small cell lung cancer (SCLC) into different subtypes. Materials and Methods Tumor and longitudinal...
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A Single Baseline Amyloid Positron Emission Tomography Could Be Sufficient for Predicting Alzheimer’s Disease Conversion in Mild Cognitive Impairment

Choo IH, Chong A, Chung JY, Ha JM, Choi YY, Kim H

Objective Baseline amyloid burden in mild cognitive impairment (MCI) has been linked to conversion to Alzheimer’s disease (AD), but the comparison of baseline and longitudinal changes in amyloid burden for...
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Effects of a Sociodrama-based Communication Enhancement Program on Mothers of Children with Neurodevelopmental Disorders: A Pilot Study

Jang SJ, Han JS, Bang MH, Ahn JW

Purpose: The incidence and prevalence of neurodevelopmental disorders have rapidly increased, indicating an urgent need for assistance through parenting interventions. This study aimed to evaluate the effects of a sociodrama-based...
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Association of Caregiver Burden With Malnutrition Among Spousal Caregiver of Cognitive Impairment

Jeon SY, Kim JL

Objective: Among old adults, caring for a spouse with cognitive decline is well-known to be associated with significant risk to the caregiver’s health such as cardiovascular disease, depression and, especially,...
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Comparison of the Predictive Power of a Combination versus Individual Biomarker Testing in Non–Small Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors

Kim H, Kwon HJ, Kim ES, Kwon S, Suh KJ, Kim SH, Kim YJ, Lee JS, Chung JH

Purpose Since tumor mutational burden (TMB) and gene expression profiling (GEP) have complementary effects, they may have improved predictive power when used in combination. Here, we investigated the ability of...
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Factors associated with anticholinergic burden among older patients in long-term care hospitals in Korea

Choi JY, Kim H, Jung Yi, Chun S, Yoo S, Lim JY, Ko JY, Park K, Kim Ki

Background/Aims: Drugs with anticholinergic properties (DAPs) are associated with adverse health outcomes in older patients. The objective of this study was to evaluate the factors that determine the prescribing of...
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Association Between Clinical Burden and Blood Eosinophil Counts in Asthma: Findings From a Korean Adult Asthma Cohort

Kim MY, Jo EJ, Kim S, Kim MH, Jung JW, Kim JH, Moon JY, Kwon JW, Lee JH, Park CS, Jin HJ, Shin YS, Kim SH, Cho YJ, Park JW, Cho SH, Kim TB, Park HK

Background: Some reports have suggested that the clinical and economic burdens of asthma are associated with blood eosinophil levels. The association between clinical burden and blood eosinophil counts were evaluated...
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Ischemic Burden Assessment Using Single Photon Emission Computed Tomography in Single Vessel Chronic Total Occlusion of Coronary Artery

Yoon YH, Han S, Kwon O, Lee K, Kim JH, Lee J, Kim To, Roh JH, Lee PH, Kang SJ, Lee JH, Kim YH, Lee CW, Moon DH, Lee SW

Background and Objectives: Studies evaluating the nature of ischemic burden of chronic total occlusion (CTO) vessels are still lacking. Methods: A total of 165 patients with single vessel CTO >2.5 mm...
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Adjustment for Multimorbidity in Estimations of the Burden of Diseases Using Korean NHIS Data

Shin Y, Choi EJ, Park B, Lee HA, Lee EK, Park H

The current multimorbidity correction method in the Global Burden of Disease studies assumes the independent occurrence of diseases. Those studies use Monte-Carlo simulations to adjust for the presence of multiple...
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The Parenting Experiences of Mothers of Children with Brain Lesions and are at Risk of Aspiration

Jeon H

Purpose: The purpose of this study was to explore the parenting experiencesthat mothers of children with brain lesions with problems swallowing had. Methods: Data was collected through in-depth interviews with...
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Correlation-based and feature-driven mutation signature analyses to identify genetic features associated with DNA mutagenic processes in cancer genomes

Jeong HY, Yoo J, Kim H, Kim TM

Mutation signatures represent unique sequence footprints of somatic mutations resulting from specific DNA mutagenic and repair processes. However, their causal associations and the potential utility for genome research remain largely...
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Evaluation of the Cut-Off Value of Fecal Immunochemical Test for Colorectal Cancer Screening during Health Checkups

Park HR, Nah EH, Lee JS, Cho S

Background: The fecal immunochemical test (FIT) is recommended as the first choice for mass colorectal cancer (CRC) screening in the community. The cut-off value can be adjusted according to the target...
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Caregiver Burden in Schizophrenia and Autism Spectrum Disorders: A Comparative Study

Yıldız M, Demir Y, Kırcalı A, İncedere A

Objective There is no study comparing schizophrenia and autism spectrum disorders (ASD) in terms of caregiver burden. This study aims to compare the caregiver burden among family members of the...
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Effect of tumor burden and radical surgery on survival difference between upfront, early interval or delayed cytoreductive surgery in ovarian cancer

Angeles MA, Cabarrou B, Gil-Moreno A, Pérez-Benavente A, Spagnolo E, Rychlik A, Martínez-Gómez C, Guyon F, Zapardiel I, Querleu D, Illac C, Migliorelli F, Bétrian S, Ferron G, Hernández A, Martinez A

Objective We sought to evaluate the impact on survival of tumor burden and surgical complexity in relation to the number of cycles of neoadjuvant chemotherapy (NACT) in patients with advanced ovarian...
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Pan-cancer Analysis of Tumor Mutational Burden and Homologous Recombination DNA Damage Repair Using Targeted Next-Generation Sequencing

Wang HY, Deng L, Li YQ, Zhang X, Long YK, Zhang X, Feng YF, He Y, Tang T, Yang XH, Wang F

Purpose Current variability in methods for tumor mutational burden (TMB) estimation and reporting demonstrates the urgent need for a homogeneous TMB assessment approach. Here, we compared TMB distributions in different...
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Measuring the Burden of Disease in Korea, 2008-2018

Jung YS, Kim YE, Park H, Oh IH, Jo MW, Ock M, Go DS, Yoon SJ

The study aims to examine the current status and differences in the burden of disease in Korea during 2008-2018. We calculated the burden of disease for Koreans from 2008 to...
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