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Nucleomodulin BspJ as an effector promotes the colonization of Brucella abortus in the host

Ma Z, Yu S, Cheng K, Miao Y, Xu Y, Hu R, Zheng W, Yi J, Zhang H, Li R, Li Z, Wang Y, Chen C

Background: Brucella infection induces brucellosis, a zoonotic disease. The intracellular circulation process and virulence of Brucella mainly depend on its type IV secretion system (T4SS) expressing secretory effectors. Secreted protein...
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Different invasion efficiencies of Brucella abortus wild-type and mutantsin RAW 264.7 and THP-1 phagocytic cells and HeLa non-phagocytic cells

Shim S, Im YB, Jung M, Park WB, Yoo HS

Brucellosis is one of the common zoonoses caused by Brucella abortus (B. abortus). However, little has been reported on factors affecting invasion of B. abortus into host cells. To investigate...
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Analysis of protein expression in Brucella abortus mutants with different growth rates by two-dimensional gel electrophoresis and LC-MS/MS peptide analysis

Park WB, Im YB, Shim S, Yoo HS

Brucella abortus is a bacterium that causes brucellosis and is the causative agent of worldwide zoonoses. Pathogenesis of the B. abortus infection is complicated, and several researchers have attempted to...
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Tannic acid-mediated immune activation attenuates Brucella abortus infection in mice

Reyes AW, Hop HT, Arayan LT, Huy TX, Min W, Lee HJ, Chang HH, Kim S

Brucellosis is an emerging infectious disease affecting humans and animals. In this study, we investigated the in vitro and in vivo effects of tannic acid (TA) against Brucella abortus infection....
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A Novel PCR Assay for Detecting Brucella abortus and Brucella melitensis

Alamian S, Esmaelizad M, Zahraei T, Etemadi A, Mohammadi , Afshar D, Ghaderi S

OBJECTIVES: Brucellosis is a major zoonotic disease that poses a significant public health threat worldwide. The classical bacteriological detection process used to identify Brucella spp. is difficult and time-consuming. This...
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Inhibitory effect of red ginseng acidic polysaccharide from Korean red ginseng on phagocytic activity and intracellular replication of Brucella abortus in RAW 264.7 cells

Bernardo Reyes AW, Simborio H, Hop HT, Arayan LT, Min WG, Lee HJ, Rhee MH, Chang HH, Kim S

Korean red ginseng (KRG) has long been used in traditional Korean and Oriental medicine. However, the anti-bacterial mechanism and therapeutic efficiency of KGR for intracellular Brucella infection are still unclear....
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Isolation and characterization of Brucella abortus isolates from wildlife species in South Korea

Truong QL, Kim K, Kim JT, Her M, Jung SC, Hahn TW

A total of 782 blood and 465 tissue samples from 1,039 wild animals and 127 dairy goats were collected from January 2011 to December 2013 in 10 provinces of South...
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Successful Medical Treatment of Prosthetic Mitral Valve Endocarditis Caused by Brucella abortus

Lee SA, Kim KH, Shin HS, Lee HS, Choi HM, Kim HK

Although Brucella endocarditis is a rare complication of human brucellosis, it is the main cause of the mortality in this disease. Traditionally, the therapeutic approach to endocarditis caused by Brucella...
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Therapeutic effects of combination of Galla rhois extract and Sodium chlorate on Mice infected with Brucella abortus

Cha CN, Hong IH, Yu EA, Park EK, Yoo CY, Kim S, Lee HJ

  • KMID: 2168981
  • J Biomed Res.
  • 2014 Mar;15(1):1-6.
This study investigated the therapeutic effects of Galla rhois (GR) ethanol extract (GRE), sodium chlorate (SC), and a combination of GRE and SC on mice infected with Brucella abortus (B....
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Protective effects of recombinant Brucella abortus Omp28 against infection with a virulent strain of Brucella abortus 544 in mice

Lim JJ, Kim DH, Lee JJ, Kim DG, Min W, Lee HJ, Rhee MH, Kim S

The outer membrane proteins (OMPs) of Brucella (B.) abortus have been extensively studied, but their immunogenicity and protective ability against B. abortus infection are still unclear. In the present study,...
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Application of the Microagglutination Test for Serologic Diagnosis of Human Brucellosis

Park SH, Lee YH, Chu H, Hwang SD, Hwang KJ, Choi HY, Park MY

Objectives Brucellosis is one of the most common zoonoses in the world, and occurs mainly in farmers, slaughterhouse workers, and veterinarians via direct or indirect contact with infected animals or their...
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The virulence of Brucella abortus isolated from cattle in Korea

Lim JJ, Kim JH, Kim DH, Lee JJ, Kim DG, Jun MH, Kim SH, Chang HH, Lee HJ, Min WG, Kim S

  • KMID: 1991810
  • Korean J Vet Res.
  • 2011 Mar;51(1):15-20.
In this study, we isolated 12 of Brucella (B.) spp. from cattle, which have been positive in Rose Bangal test and tube agglutination test in Gyeongbuk province in 2009. According...
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Brucella Endocarditis with Splenic Abscess: A Report of the First Case Diagnosed in Korea

Park SH, Choi YS, Choi YJ, Cho SH, Yoon HJ

Human brucellosis has a broad spectrum of clinical manifestations, which includes endocarditis, a focal complication that is uncommon yet responsible for the majority of associated deaths. The most successful treatment...
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Clinical Characteristics of Human Brucellosis in South Korea

Kim YS, Sill CY, Oh WS, Kwon KT, Lee H, Lee SH, Son JS, Kim SW, Chang HH, Jung SI, Ko KS, Park MY, Peck KR, Song JH

  • KMID: 2285062
  • Infect Chemother.
  • 2006 Dec;38(6):334-343.
BACKGROUND: Since the first Korean case of human brucellosis was reported in 2002, the incidence of human brucellosis has been rapidly increasing. We performed this study to evaluate the clinical...
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Investigation of a Series of Brucellosis Cases in Gyeongsangbuk-do during 2003-2004

Lim HS, Min YS, Lee HS

  • KMID: 792381
  • J Prev Med Public Health.
  • 2005 Nov;38(4):482-488.
OBJECTIVES: We conducted an investigation on 14 cases of brucellosis in Gyeongsangbuk-do during 2003-2004 to understand the source of infection and the transmission routes of brucellosis. METHODS: The authors visited the...
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The First Case of Human Brucellosis in Korea

Park MS, Woo YS, Lee MJ, Shim SK, Lee HK, Choi YS, Lee WH, Kim KH, Park MY

  • KMID: 2285150
  • Infect Chemother.
  • 2003 Dec;35(6):461-466.
Brucellosis is usually transmitted to human by direct contact with infected animals or by ingestion of unpasteurized dairy products. Because of the wide spectrum of its clinical manifestations, brucellosis may...
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