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Clinical application of urinary leukotriene E4 in bronchial asthma

Yoon HK, Shin Y, Lee SH, Lee SY, Kim SC, Kim KH, Moon HS, Song JS, Park SH

  • KMID: 2285928
  • J Asthma Allergy Clin Immunol.
  • 2001 Aug;21(4):600-609.
BACKGROUND: Cysteinyl leukotrienes are important inflammatory mediators in bronchial asthma because they enhance microvascular permeability, increase nonspecific bronchial hyperresponsiveness, and are potent bronchoconstrictor agents. Leukotriene E4 is a major metabolite...
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Methacholine and Adenosine 5'-monophosphate Challenge Tests in Children with Asthma: Relationship to Eosinophil Markers in Blood

  • KMID: 2299638
  • Korean J Asthma Allergy Clin Immunol.
  • 2006 Mar;26(1):52-58.
BACKGROUND: Bronchial hyperresponsiveness (BHR) in asthma is thought to be a consequence of underlying airway inflammation. OBJECTIVE: The aim of this study was to assess the relationship between blood eosinophil...
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Airway Reactivity to Bronchoconstrictor and Bronchodilator: Assessment Using Thin-Section and Volumetric Three-Dimensional CT

Han BK, Im JG, Kim HS, Koo JM, Ki HD, Yeon KM, Kim HD

OBJECTIVE: To determine the extent to which thin-section and volumetric three-dimensional CT can depict airway reactivity to bronchostimulator, and to assess the effect of different airway sizes on the degree...
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Airways are More Reactive to Histamine than to Methacholine in Patients with Mild Airway Hyperresponsiveness, Regardless of Atopy

Choi IS, Lee S, Kim DH, Chung SW, Lee YC, Cho JY, Lee WJ

BACKGROUND: The airway muscles from allergen-sensitized animals in vitro show a heightened response to histamine, but not to carbachol. This study investigated whether the airway responsiveness to histamine in...
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Airway Hyperresponsiveness to Hypertonic Saline as a Predictive Index of Exercise-Induced Bronchoconstriction

Choi IS, Chung SW, Koh YI, Sim MK, Hong SN, Moon JS

BACKGROUND: Changes in airway mucosal osmolarity are an underlying mechanism of bronchoconstrictive responses to exercise and hypertonic saline (HS). The purpose of this study was to examine whether an osmotic...
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Asthmatic Airway Inflammation is More Closely Related to Airway Hyperresponsiveness to Hypertonic Saline than to Methacholine

Choi IS, Hong SN, Lee YK, Koh YI, Jang AS, Lee HC

  • KMID: 1106140
  • Korean J Intern Med.
  • 2003 Jun;18(2):83-88.
BACKGROUND: Airway hyperresponsiveness (AHR) to direct stimuli, such as methacholine (MCh), is observed not only in asthma but other diseases. AHR to indirect stimuli is suggested to be more specific...
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