- Attenuation of airway inflammation by simvastatin and the implications for asthma treatment: is the jury still out?
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Liu JN, Suh DH, Yang EM, Lee SI, Park HS, Shin YS
- KMID: 2155378
- Exp Mol Med.
- 2014 Sep;46(9):e113.
- doi: 10.1038/emm.2014.55
Although some studies have explained the immunomodulatory effects of statins, the exact mechanisms and the therapeutic significance of these molecules remain to be elucidated. This study not only evaluated the... -
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- The Soluble Tumor Necrosis Factor-Alpha Receptor Suppresses Airway Inflammation in a Murine Model of Acute Asthma
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Nam HS, Lee SY, Kim SJ, Kim JS, Kwon SS, Kim YK, Kim KH, Moon HS, Song JS, Park SH, Kim SC
- KMID: 1758619
- Yonsei Med J.
- 2009 Aug;50(4):569-575.
- doi: 10.3349/ymj.2009.50.4.569
PURPOSE: Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in many aspects of the airway pathology in asthma. TNF-alpha blocking strategies are now being tried in... -
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- Mast cells play a key role in Th2 cytokine-dependent asthma model through production of adhesion molecules by liberation of TNF-alpha
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Chai OH, Han EH, Lee HK, Song CH
- KMID: 991621
- Exp Mol Med.
- 2011 Jan;43(1):35-43.
- doi: 10.3858/emm.2011.43.1.004
Mast cells are well recognized as key cells in allergic reactions, such as asthma and allergic airway diseases. However, the effects of mast cells and TNF-alpha on T-helper type 2... -
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- The Effect of CpG-Oligodeoxynucleotides with Different Backbone Structures and 3' Hexameric Deoxyriboguanosine Run Conjugation on the Treatment of Asthma in Mice
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Chang YS, Kim YK, Kwon HS, Park HW, Min KU, Kim YY, Cho SH
- KMID: 1782007
- J Korean Med Sci.
- 2009 Oct;24(5):860-866.
- doi: 10.3346/jkms.2009.24.5.860
CpG-Oligodeoxynucleotide (ODN) has two backbones. Phosphorothioate backbone (PS) shows a strong immunostimulating effect while phosphodiester (PE) shows little in vivo. 3' hexameric deoxyriboguanosine-run (3' dG6-run) conjugation to PE CpG-ODN has... -
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