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Current Asthma Prevalence Using Methacholine Challenge Test in Korean Children from 2010 to 2014

Woo H, Samra MS, Lim DH, Kim JH

Background: Most epidemiological studies depend on the subjects' response to asthma symptom questionnaires. Questionnaire-based study for childhood asthma prevalence may overestimate the true prevalence. The aim of this study was...
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Sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthma

Kim YH, Jang YY, Jeong J, Chung HL

Background: Bronchial hyperresponsiveness (BHR), an important physiological feature of asthma, is a prognostic marker of childhood asthma. Purpose: We aimed to investigate the factors associated with BHR in adolescents with childhood...
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The Association of Lung Function, Bronchial Hyperresponsiveness, and Exhaled Nitric Oxide Differs Between Atopic and Non-atopic Asthma in Children

Shim E, Lee E, Yang SI, Jung YH, Park GM, Kim HY, Seo JH, Yu J

PURPOSE: Although many previous studies have attempted to identify differences between atopic asthma (AA) and non-atopic asthma (NAA), they have mainly focused on the difference of each variable of lung...
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Influence of Chronic Sinusitis and Nasal Polyp on the Lower Airway of Subjects Without Lower Airway Diseases

Lee SY, Yoon SH, Song WJ, Lee SH, Kang HR, Kim SS, Cho SH

PURPOSE: Upper and lower respiratory tract pathologies are believed to be interrelated; however, the impact of upper airway inflammation on lung function in subjects without lung disease has not been...
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The effect of atopy and allergic diseases on pulmonary function of Korean adolescents

Hwangbo JW, Kwon JW, Seo JH, Kim HY, Yu JH, Kim HB, Kim WK, Jang GC, Song DJ, Shim JY, Hong SJ, Lee SY

PURPOSE: Pulmonary function test (PFT) plays a key role in the diagnosis and management of asthma in adolescents. But, it is not clear whether adolescents with asthma have significantly reduced...
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Association between Recent Acetaminophen Use and Asthma: Modification by Polymorphism at TLR4

Lee SH, Kang MJ, Yu HS, Hong K, Jung YH, Kim HY, Seo JH, Kwon JW, Kim BJ, Kim HJ, Kim YJ, Kim HS, Kim HB, Park KS, Lee SY, Hong SJ

The risk of asthma has been increasing in parallel with use of acetaminophen, which is a potential source of oxidative stress. Toll-like receptor 4 (TLR4) plays a critical role not...
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Relationship Between Atopy and Bronchial Hyperresponsiveness

Suh DI, Koh YY

Both atopy and bronchial hyperresponsiveness (BHR) are characteristic features of asthma. They are also found among non-asthmatic subjects, including allergic rhinitis patients and the general population. Atopy and BHR in...
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Forced expiratory flow between 25% and 75% of vital capacity as a predictor for bronchial hyperresponsiveness in children with allergic rhinitis

Park HB, Kim YH, Kim MJ, Kim HS, Lee HS, Han YK, Kim KW, Sohn MH, Kim KE

PURPOSE: Allergic rhinitis (AR) is regarded as a risk factor for asthma and bronchial hyperresponsiveness (BHR) is frequently observed in patients with AR. The purpose of this study is to...
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Long-term asthma remission during adolescence

Koh YY

Asthma is a heterogeneous disorder with a variable course, characterized by episodes of cough, wheezing and shortness of breath, reversible airflow limitation, and bronchial hyperresponsiveness (BHR). It begins early in...
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Relationship between Bronchial Hyperresponsiveness and Development of Asthma in Preschool Children with Cough Variant Asthma

Lee JK, Lee EJ, Song JH, Suh DI, Koh YY

  • KMID: 2315300
  • Pediatr Allergy Respir Dis.
  • 2012 Dec;22(4):364-373.
PURPOSE: A significant proportion of patients with cough variant asthma (CVA) eventually develops asthma. The aim of this study was to investigate the relationship between bronchial hyperresponsiveness (BHR) and development...
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The Association of Obesity, Airway Hyperresponsiveness and Atopy in Chronic Cough Patients: Results of a Two-Center Study

Park SY, Park JW, Oh YM, Rhee YK, Lee YM, Park YB, Lim SY, Korean Asthma Study Group

  • KMID: 2319542
  • Tuberc Respir Dis.
  • 2011 Jul;71(1):24-29.
BACKGROUND: The rising prevalence of asthma worldwide may be associated with the rising prevalence of obesity in developed nations. Although several studies have suggested a relationship between asthma and obesity,...
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Bronchodilator Response and Its Relationship to Bronchial Hyperresponsiveness in Children with Allergic Rhinitis/Asthma

Suh DI, Lee JK, Lee JH, Koh YY

  • KMID: 2315016
  • Pediatr Allergy Respir Dis.
  • 2010 Mar;20(1):59-67.
PURPOSE: Bronchial impairment has been observed in patients with allergic rhinitis (AR) as well as asthma. Few reports exist on bronchodilator response (BDR) and its relationship with bronchial hyperresponsiveness (BHR)...
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Serum Ghrelin Level is Associated with Severity of Bronchial Hyperresponsiveness

  • KMID: 2299577
  • Korean J Asthma Allergy Clin Immunol.
  • 2009 Mar;29(1):46-52.
BACKGROUND: The prevalences of both asthma and obesity have increased. One possibility of this increase is systemic changes in immune function in obese subjects. Several obesity-related hormones and cytokines have...
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Relationships of Methacholine and Adenosine 5'-Monophosphate Responsiveness with deltaFVC in Children with Allergic Rhinitis

Lee JH, Lee JK, Suh DI, Koh YY

  • KMID: 2315003
  • Pediatr Allergy Respir Dis.
  • 2009 Dec;19(4):410-419.
PURPOSE: Patients with allergic rhinitis without clinical evidence of asthma often have bronchial hyperresponsiveness (BHR). BHR is commonly assessed by bronchial challenges using direct or indirect stimuli. The percentage decrease...
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Comparison of Methacholine and Adenosine 5'-Monophosphate Responsiveness Between Preschool Children with Atopic Asthma and Those with Nonatopic Asthma

Lee JH, Lee JK, Suh DI, Koh YY

  • KMID: 2315002
  • Pediatr Allergy Respir Dis.
  • 2009 Dec;19(4):401-409.
PURPOSE: It is well known that atopy is a major determinant of bronchial hyperresponsiveness (BHR) in both asymptomatic and asthmatic children. However, the relationship between atopy and BHR has not...
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Characteristics of Atopy and Pulmonary Functions According to the Wheezing Phenotype in Preschool Children

Song YH, Kim BJ, Kwon JW, Yu J, Hong SJ

  • KMID: 2314995
  • Pediatr Allergy Respir Dis.
  • 2009 Dec;19(4):335-344.
PURPOSE: The wheezing phenotype in early childhood is heterogeneous and does not always develop asthma. However, the severity of the disease associated with these phenotypes has not been extensively studied...
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Utility of a forced expiratory flow of 25 to 75 percent as a predictor in children with asthma

Kang JW, Kim KW, Kim ES, Park JY, Sohn MH, Kim KE

PURPOSE: Asthma is defined as chronic inflammation of the lower small airways, and bronchial hyperreactivity (BHR) is a pathophysiologic feature of asthma. It has been proposed that although there is...
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Changes in Bronchial Hyperresponsiveness in Children with Asthma

Kim GH, Seo KJ, Byeon JH, Song DJ, Yoo Y, Choung JT, Koh YY

  • KMID: 2314509
  • Pediatr Allergy Respir Dis.
  • 2007 Sep;17(3):196-205.
PURPOSE: The aim of this study was to investigate changes in bronchial hyperresponsiveness, total IgE, blood total eosinophil counts and serum eosinophil cationic protein (ECP), after treatment with inhaled corticosteroids...
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Prevalence of Allergic Diseases in High School Students in Korea

  • KMID: 2299612
  • Korean J Asthma Allergy Clin Immunol.
  • 2007 Sep;27(3):168-175.
BACKGROUND: Whereas allergic disease has a high morbidity among adolescents, there have been few reports concerning asthma prevalence using objective parameters such as methacholine bronchial provocation tests in this age...
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Analysis of the association between bronchial hyperresponsiveness and genetic polymorphism of beta2-adrenoceptor in adolescents with long-term asthma remission

Kang H, Koh YY

PURPOSE: We hypothesized that the persisting bronchial hyperresponsiveness (BHR) of adolescents with asthma remission may be controlled mainly by genetic factors, and the BHR of symptomatic asthma by airway inflammation....
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