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The Soluble Tumor Necrosis Factor-Alpha Receptor Suppresses Airway Inflammation in a Murine Model of Acute Asthma

Nam HS, Lee SY, Kim SJ, Kim JS, Kwon SS, Kim YK, Kim KH, Moon HS, Song JS, Park SH, Kim SC

PURPOSE: Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in many aspects of the airway pathology in asthma. TNF-alpha blocking strategies are now being tried in...
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Airways are More Reactive to Histamine than to Methacholine in Patients with Mild Airway Hyperresponsiveness, Regardless of Atopy

Choi IS, Lee S, Kim DH, Chung SW, Lee YC, Cho JY, Lee WJ

BACKGROUND: The airway muscles from allergen-sensitized animals in vitro show a heightened response to histamine, but not to carbachol. This study investigated whether the airway responsiveness to histamine in...
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