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Noninvasive Helicobacter pylori Diagnostic Methods in Indonesia

Miftahussurur M

Although the prevalence of Helicobacter pylori infection in Indonesia is lower than that in other countries, H. pylori is still an essential pathogen associated with severe gastric mucosal damage and...
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Prevalence of Disaccharidase Deficiency in Adults With Unexplained Gastrointestinal Symptoms

Viswanathan L, Rao SSC, Kennedy K, Sharma A, Yan Y, Jimenez E

  • KMID: 2504007
  • J Neurogastroenterol Motil.
  • 2020 Jul;26(3):384-390.
  • doi: 10.5056/jnm19167
Background/Aims Disaccharidase assay is used for assessing carbohydrate intolerance in children, but its usefulness in adults is not known. The aim of this study is to assess the prevalence of...
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Nutrient Challenge Testing Is Not Equivalent to Scintigraphy−Lactulose Hydrogen Breath Testing in Diagnosing Small Intestinal Bacterial Overgrowth

Schindler V, Huellner M, Murray F, Schnurre L, Becker AS, Bordier V, Pohl D

  • KMID: 2507117
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):514-520.
  • doi: 10.5056/jnm19162
Background/Aims Small intestinal bacterial overgrowth (SIBO) is a common condition in disorders of gut-brain interaction (DGBI). Recently, a combined scintigraphy–lactulose hydrogen breath test (ScLHBT) was described as an accurate tool diagnosing...
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Breath Tests for the Non-invasive Diagnosis of Small Intestinal Bacterial Overgrowth: A Systematic Review With Meta-analysis

Losurdo G, Leandro G, Ierardi E, Perri F, Barone M, Principi M, Leo AD

  • KMID: 2500647
  • J Neurogastroenterol Motil.
  • 2020 Jan;26(1):16-28.
  • doi: 10.5056/jnm19113
Background/Aims Small intestinal bacterial overgrowth (SIBO) diagnosis is usually based on non-invasive breath tests (BTs), namely lactulose BT (LBT) and glucose BT (GBT). However, divergent opinions and problems of parameter...
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Influencing Factors on Lactulose Breath Test Results

Kim JW, Park SY, Chung JO, Cho HA, Kim DH, Yoon JH, Park CH, Kim HS, Choi SK, Rew JS

BACKGROUND/AIMS: This study aimed to identify the demographic and clinical factors associated with positive breath-test results and to assess the relationship between hydrogen and methane production in patients with suspected...
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Association Between Symptoms, Quality of Life, and Gastric Emptying in Dyspeptic Patients

Wuestenberghs F, Juge M, Melchior C, Desprez C, Leroi AM, Gourcerol

  • KMID: 2460483
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):534-543.
  • doi: 10.5056/jnm19060
BACKGROUND/AIMS: Association between symptoms, quality of life and gastric emptying in dyspepsia is inconsistent in the literature. The aim of our study is to investigate if gastric emptying is associated...
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Prevalence of Fructose Malabsorption in Patients With Irritable Bowel Syndrome After Excluding Small Intestinal Bacterial Overgrowth

Jung KW, Seo M, Cho YH, Park YO, Yoon SY, Lee J, Yang DH, Yoon IJ, Seo SY, Lee HJ, Park SH, Kim KJ, Ye BD, Byeon JS, Jung HY, Yang SK, Kim JH, Myung SJ

  • KMID: 2413107
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):307-316.
  • doi: 10.5056/jnm17044
BACKGROUND/AIMS: Fructose malabsorption (FM) mimics symptoms of irritable bowel syndrome (IBS), and its prevalence has increased. Diagnosing FM in IBS is challenging because of its overlap with small intestinal bacterial...
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Is It Useful to Administer Probiotics Together With Proton Pump Inhibitors in Children With Gastroesophageal Reflux?

Belei O, Olariu L, Dobrescu A, Marcovici , Marginean

  • KMID: 2417272
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):51-57.
  • doi: 10.5056/jnm17059
BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD) is a frequent condition diagnosed in children and treated with proton pump inhibitors (PPI). Long-term PPI administration can alter intestinal bacterial population by suppressing the...
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Obesity Is Inversely Related to Hydrogen-Producing Small Intestinal Bacterial Overgrowth in Non-Constipation Irritable Bowel Syndrome

Jung SE, Joo NS, Han KS, Kim KN

There have been inconsistent findings on the association of obesity and non-constipation irritable bowel syndrome (IBS). Small intestinal bacterial overgrowth (SIBO) with hydrogen (Hâ‚‚) gas forming-microflora causes non-constipation IBS. But,...
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Positive Glucose Breath Tests in Patients with Hysterectomy, Gastrectomy, and Cholecystectomy

Kim DB, Paik CN, Kim YJ, Lee JM, Jun KH, Chung WC, Lee KM, Yang JM, Choi MG

BACKGROUND/AIMS: This study aimed to investigate the prevalence and characteristics of small intestinal bacterial overgrowth (SIBO) in patients undergoing abdominal surgeries, such as gastrectomy, cholecystectomy, and hysterectomy. METHODS: One hundred seventy-one...
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Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy

Ghoshal UC, Shukla R, Ghoshal U

The pathogenesis of irritable bowel syndrome (IBS), once thought to be largely psychogenic in origin, is now understood to be multifactorial. One of the reasons for this paradigm shift is...
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Severe Delayed Gastric Emptying Induces Non-acid Reflux up to Proximal Esophagus in Neurologically Impaired Patients

Ishii S, Fukahori S, Asagiri K, Tanaka Y, Saikusa N, Hashizume , Yoshida M, Masui D, Komatsuzaki N, Higashidate N, Sakamoto S, Kurahachi , Tsuruhisa , Nakahara H, Yagi M

  • KMID: 2395421
  • J Neurogastroenterol Motil.
  • 2017 Oct;23(4):533-540.
  • doi: 10.5056/jnm16211
BACKGROUND/AIMS: The aim of this study is to investigate the degree of delayed gastric emptying (DGE) and evaluate how the severity of DGE affects gastroesophageal reflux disease (GERD) in neurologically...
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Updates on the Diagnosis of Helicobacter pylori Infection in Children: What Are the Differences between Adults and Children?

Yang HR

Helicobacter pylori infection is acquired mainly during childhood and causes various diseases such as gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and iron deficiency anemia. Although H. pylori...
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Irritable Bowel Syndrome, Particularly the Constipation-Predominant Form, Involves an Increase in Methanobrevibacter smithii, Which Is Associated with Higher Methane Production

Ghoshal U, Shukla R, Srivastava D, Ghoshal UC

BACKGROUND/AIMS: Because Methanobrevibacter smithii produces methane, delaying gut transit, we evaluated M. smithii loads in irritable bowel syndrome (IBS) patients and healthy controls (HC). METHODS: Quantitative real-time polymerase chain reaction for...
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Small Intestinal Bacterial Overgrowth in Patients with Refractory Functional Gastrointestinal Disorders

Shimura S, Ishimura N, Mikami H, Okimoto E, Uno G, Tamagawa Y, Aimi M, Oshima N, Sato S, Ishihara S, Kinoshita

  • KMID: 2379704
  • J Neurogastroenterol Motil.
  • 2016 Jan;22(1):60-68.
  • doi: 10.5056/jnm15116
BACKGROUND/AIMS: Small intestinal bacterial overgrowth (SIBO) is considered to be involved in the pathogenesis of functional gastrointestinal disorders (FGID). However, the prevalence and clinical conditions of SIBO in patients with...
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Efficacy of Lactose-free Milk in Korean Adults with Lactose Intolerance

Park SH, Chang YW, Kim SJ, Lee MH, Nam JH, Oh CH, Kim JW, Jang JY, Yang JO, Yoo JA, Chung JY

BACKGROUND/AIMS: Lactose-free milk (LFM) is available for nutrient supply for those with lactose intolerance (LI). However, there are no consistent results of the efficacy of LFM in LI subjects. We...
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Determination of Rifaximin Treatment Period According to Lactulose Breath Test Values in Nonconstipated Irritable Bowel Syndrome Subjects

Bae S, Lee KJ, Kim YS, Kim KN

Small intestinal bacterial overgrowth (SIBO) can partly explain irritable bowel syndrome (IBS), and rifaximin has been observed to improve abdominal symptoms in nonconstipated IBS patients. However, there are few reports...
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Changing Prevalence of Helicobacter pylori Infections in Korean Children with Recurrent Abdominal Pain

Jang KM, Choe BH, Choe JY, Hong SJ, Park HJ, Chu MA, Cho SM, Kim JM

PURPOSE: The aim of this study is to investigate the changing prevalence rate of Helicobacter pylori infection in children, of different age groups, with recurrent abdominal pain over a 10-year...
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Small Intestinal Bacterial Overgrowth Diagnosed by Glucose Hydrogen Breath Test in Post-cholecystectomy Patients

Sung HJ, Paik CN, Chung WC, Lee KM, Yang JM, Choi MG

  • KMID: 2381303
  • J Neurogastroenterol Motil.
  • 2015 Oct;21(4):545-551.
  • doi: 10.5056/jnm15020
BACKGROUND/AIMS: Patients undergoing cholecystectomy may have small intestinal bacterial overgrowth (SIBO). We investigated the prevalence and characteristics of SIBO in patients with intestinal symptoms following cholecystectomy. METHODS: Sixty-two patients following cholecystectomy,...
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Anti-Helicobacter pylori activities of FEMY-R7 composed of fucoidan and evening primrose extract in mice and humans

Kim TS, Choi EK, Kim J, Shin K, Lee SP, Choi Y, Jeon JH, Kim YB

Helicobacter pylori-eliminating effects of FEMY-R7, composed of fucoidan and evening primrose extract, were investigated in mice and humans. Male C57BL/6 mice were infected with the bacteria by intragastric inoculation (1x10(9)...
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