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The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans

Bailone RL, Fukushima HCS, Aguiar LKd, Borra RC

Zebrafish is considered an unprecedented animal model in drug discovery. A review of the literature presents highlights and elucidates the biological effects of chemical components found in Cannabis sativa. Particular...
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Zebrafish as an alternative animal model in human and animal vaccination research

Bailone RL, Fukushima HCS, Fernandes BHV, Aguiar LKD, Corrêa T, Janke H, Setti PG, Oliveira Roça RD, Borra RC

Much of medical research relies on animal models to deepen knowledge of the causes of animal and human diseases, as well as to enable the development of innovative therapies. Despite...
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Efficacy of instillation of MB49 cells and thermoreversible polymeric gel in urothelial bladder carcinoma immunization

Santana JPP, Marcato PD, Massaro TNC, Godoy NL, Anibal FdF, Borra RC

Background: Activating the immune system for therapeutic benefit has long been a goal in immunology, especially in cancer treatment, but the low immunogenicity of antitumor vaccines remains a limiting factor...
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Zebrafish toxicological screening could aid Leishmaniosis drug discovery

Fukushima HCS, Bailone RL, Corrêa T, Janke H, Aguiar LKD, Setti PG, Borra RC

Background: Recently a screen from a library of 1.8 million compounds identified in vitro a potent activity of the 2-aminobenzimidazoles series against Leishmania infantum, the etiological agent responsible by over...
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