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Eight-week healing of grafted calvarial bone defects with hyperbaric oxygen therapy in rats

Oh SE, Hu KS, Kim S

PURPOSE: The purpose of this study was to evaluate the synergistic effect of adjunctive hyperbaric oxygen (HBO) therapy on new bone formation and angiogenesis after 8 weeks of healing. METHODS: Sprague-Dawley...
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Bone Morphogenetic Protein 2-Conjugated Silica Particles Enhanced Early Osteogenic Differentiation of Adipose Stem Cells on the Polycaprolactone Scaffold

Kim KJ, Choi MS, Shim JH, Rhie JW

BACKGROUND: Silica particles (SPs) induce cell proliferation and osteogenic differentiation. We reported that SPs in the scaffold induced early stage osteogenic differentiation. METHODS: A polycaprolactone (PCL) scaffold was fabricated with a...
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Improvement of the osteogenic potential of ErhBMP-2-/EGCG-coated biphasic calcium phosphate bone substitute: in vitro and in vivo activity

Hwang JH, Oh S, Kim S

PURPOSE: The aim of this study was to evaluate the enhancement of osteogenic potential of biphasic calcium phosphate (BCP) bone substitute coated with Escherichia coli-derived recombinant human bone morphogenetic protein-2...
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Biodegradable Screws Containing Bone Morphogenetic Protein-2 in an Osteoporotic Rat Model

Jin ES, Kim JY, Lee B, Min J, Jeon SR, Choi KH, Jeong JH

OBJECTIVE: The aim of this study was to evaluate the effect for biodegradable screws containing bone morphogenetic protein-2 (BMP-2) in an osteoporotic rat model. METHODS: Twenty-four female Wistar rat (250–300 g,...
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Combined effect of recombinant human bone morphogenetic protein-2 and low level laser irradiation on bisphosphonate-treated osteoblasts

Jeong SY, Hong JU, Song JM, Kim IR, Park BS, Kim CH, Shin SH

OBJECTIVES: The purpose of this study was to evaluate the synergic effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) and low-level laser therapy (LLLT) on bisphosphonate-treated osteoblasts. MATERIALS AND METHODS: Human...
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Evaluation of bone healing using rhBMP-2 soaked hydroxyapatite in ridge augmentation: a prospective observational study

Kim HS, Park JC, Yun PY, Kim YK

BACKGROUND: The goal of this study is to evaluate complication and effectiveness of alveolar ridge augmentations using a hydroxyapatite-based alloplastic bony substitute with rhBMP-2. METHODS: A total of 10 patients (4...
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Recombinant Human Bone Morphogenetic Protein-2 in Posterolateral Spinal Fusion: What's the Right Dose?

Hoffmann M, Jones CB, Sietsema D

STUDY DESIGN: Single center retrospective cohort analysis. PURPOSE: The goal was to evaluate the influence of varying amount of recombinant human bone morphogenetic protein 2 (rhBMP-2) per level on fusion rates...
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Comparative analysis of carrier systems for delivering bone morphogenetic proteins

Jung IH, Lim HC, Lee EU, Lee JS, Jung UW, Choi SH

PURPOSE: The objective of this study was to comparatively assess the bone regenerative capacity of absorbable collagen sponge (ACS), biphasic calcium phosphate block (BCP) and collagenated biphasic calcium phosphate (CBCP)...
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Combined effect of bisphosphonate and recombinant human bone morphogenetic protein 2 on bone healing of rat calvarial defects

Kim HC, Song JM, Kim CJ, Yoon SY, Kim IR, Park BS, Shin SH

PURPOSE: This study aimed to investigate new bone formation using recombinant human bone morphogenetic protein 2 (rhBMP-2) and locally applied bisphosphonate in rat calvarial defects. METHODS: Thirty-six rats were studied. Two...
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A Novel Osteogenic Activity of Suberoylanilide Hydroxamic Acid is Synergized by BMP-2

Lee ZH, Kim HJ, Ryoo HM

BACKGROUND: Many histone deacetylase (HDAC) inhibitors are well recognized as potential anti-cancer drugs. Inhibition of HDACs induces temporal transcription or epigenetic control, thus regulating many different biological responses. Here, we...
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Bone formation around rhBMP-2-coated implants in rabbit sinuses with or without absorbable collagen sponge grafting

Baek WS, Yoon SR, Lim HC, Lee JS, Choi SH, Jung UW

PURPOSE: The purpose of this study was to evaluate bone formation around recombinant human bone morphogenetic protein (rhBMP-2)-coated implants placed with or without absorbable collagen sponge (ACS) in rabbit maxillary...
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Paracrine effect of the bone morphogeneticprotein-2 at the experimental site on healing of the adjacent control site: a study in the rabbit calvarial defect model

Lee JW, Lim HC, Lee EU, Park JY, Lee JS, Lee DW, Jung UW, Choi SH

PURPOSE: The aim of this study was to assess the possible paracrine effect of bone morphogeneticprotein-2 (BMP-2) at the experimental site on the adjacent control site for validating a rabbit...
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Bone Healing Properties of Autoclaved Autogenous Bone Grafts Incorporating Recombinant Human Bone Morphogenetic Protein-2 and Comparison of Two Delivery Systems in a Segmental Rabbit Radius Defect

Choi EJ, Kang SH, Kwon HJ, Cho SW, Kim HJ

  • KMID: 1910869
  • Maxillofac Plast Reconstr Surg.
  • 2014 May;36(3):94-102.
PURPOSE: This study aims to validate the effect of autoclaved autogenous bone (AAB), incorporating Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2), on critical-sized, segmental radius defects in rabbits. Delivery...
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Improvement of osteogenic potential of biphasic calcium phosphate bone substitute coated with two concentrations of expressed recombinant human bone morphogenetic protein 2

Choi H, Park NJ, Jamiyandorj O, Choi KH, Hong MH, Oh S, Park YB, Kim S

PURPOSE: The aim of this study was to determine whether biphasic calcium phosphate (BCP) bone substitute with two different concentrations of Escherichia coli-expressed recombinant human bone morphogenetic protein 2 (ErhBMP-2)...
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Comparison between heparin-conjugated fibrin and collagen sponge as bone morphogenetic protein-2 carriers for bone regeneration

Yang HS, La WG, Cho YM, Shin W, Yeo GD, Kim BS

  • KMID: 1383796
  • Exp Mol Med.
  • 2012 May;44(5):350-355.
Bone morphogenetic protein-2 (BMP-2) is used to promote bone regeneration. However, the bone regeneration ability of BMP-2 relies heavily on the delivery vehicle. Previously, we have developed heparin-conjugated fibrin (HCF),...
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Msx2 mediates the inhibitory action of TNF-alpha on osteoblast differentiation

Lee HL, Yi T, Woo KM, Ryoo HM, Kim GS, Baek JH

TNF-alpha, a proinflammatory cytokine, inhibits osteoblast differentiation under diverse inflammatory conditions; however, the underlying mechanisms in terms of the TNF-alpha signaling pathway remain unclear. In this study, we examined the...
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Modulation of cartilage differentiation by melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP)

Schubert T, Schlegel J, Schmid R, Opolka A, Grassel S, Humphries , Bosserhoff AK

Melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP) is a small soluble protein secreted from malignant melanoma cells and from chondrocytes. Recently, we revealed that MIA/CD-RAP can modulate bone morphogenetic protein...
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Evaluation of bone formation by recombinant human BMP-2 and rapid prototype titanium cap in rabbit calvaria using micro computed tomography

Han MS, Jung S, Kim BS, Yang JW, Kook MS, Park HJ, Ryu SY, Oh HK

  • KMID: 2328583
  • J Korean Assoc Oral Maxillofac Surg.
  • 2010 Dec;36(6):466-472.
INTRODUCTION: This study examined the effect of recombinant human bone morphogenetic protein (rhBMP)-2 and beta-tricalcium phosphate (beta-TCP) on new bone formation in a rabbit calvarium using a rapid prototype titanium...
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Effect of combinatorial bone morphogenetic protein 2 and bone morphogenetic protein 7 gene delivery on osteoblastic differentiation

Bae Y, Kim KH, Kim SH, Lee CW, Koo KT, Kim TI, Seol YJ, Ku Y, Rhyu IC, Chung CP, Lee YM

  • KMID: 2321654
  • J Korean Acad Periodontol.
  • 2009 Aug;39(Suppl):279-286.
PURPOSE: Gene therapy (ex vivo) has recently been used as a means of delivering bone morphogenetic proteins (BMPs) to sites of tissue regeneration. In the present study, we investigated the...
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Use of Long-term Cultured Embryoid Bodies May Enhance Cardiomyocyte Differentiation by BMP2

Kim YY, Ku SY, Jang J, Oh SK, Kim HS, Kim SH, Choi YM, Moon SY

PURPOSE: Human embryonic stem cells (hESCs) can proliferate for a prolonged period and differentiate into cardiomyocytes in vitro. Recent studies used bone morphogenetic protein 2 (BMP2) to generate cardiomyocytes from...
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