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A critical assessment of the medication-related osteonecrosis of the jaw classification in stage I patients: a retrospective analysis

Ristow O, Hürtgen L, Moratin J, Smielowski M, Freudlsperger C, Engel M, Hoffmann J, Rückschloß T

Objectives: It is unclear whether the extent of intraoral mucosa defects in patients with medication-related osteonecrosis of the jaw indicates disease severity. Therefore, this study investigated whether mucosal lesions correlate...
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The effect of melatonin on prevention of bisphosphonate-related osteonecrosis of the jaw: an animal study in rats

Yadegari A, Aminzadeh A, Seyyedkhamesi S, Aminian M

Objectives: Melatonin induces human stem cells, converts pre-osteoblasts to mature osteoblasts, and reduces the duration of this transition. However, melatonin itself prevents activation of osteoclasts. Here, we evaluate the role...
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Prevalence and Risk Factors of Atypical Femoral Fracture Bone Scintigraphic Feature in Patients Experiencing Bisphosphonate-Related Osteonecrosis of the Jaw

Lee CH, Son SH, Hong CM, Jeong JH, Jeong SY, Lee SW, Lee J, Kwon TG, Ahn BC

PURPOSE: Bisphosphonate (BP) is the first-line therapy for the management of osteoporosis. BP-related osteonecrosis of the jaw (BRONJ) and atypical femoral fracture (AFF) are increasingly common comorbidities in patients with...
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Bisphosphonate-related osteonecrosis of the jaw in metastatic breast cancer patients: a review of 25 cases

Kim HJ, Park TJ, Ahn KM

BACKGROUND: Intravenous bisphosphonates have been used in metastatic breast cancer patients to reduce pathologic bone fracture and bone pain. However, necrosis of the jaw has been reported in those who...
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Bisphosphonate-related osteonecrosis of the jaw in a patient with osteoporosis following treatment of testicular cancer: a case report

Kim DS, Kim JH, Ohe JY, Lee JW, Choi BJ, Lee BS, Kwon YD

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) occurs mainly in female patients. In males the occurrence rate is low, which seems to be related to the low incidence of osteoporosis in...
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Effect of alendronate on bone remodeling around implant in the rat

Park R, Kim JH, Choi H, Park YB, Jung HS, Moon HS

PURPOSE: The purpose of this study was to evaluate the effect of alendronates on bone remodeling around titanium implant in the maxilla of rats. MATERIALS AND METHODS: The maxillary first molars...
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A Case of Intractable Bisphosphonate-Related Osteonecrosis of the Jaw Treated with Teriparatide

Lee S, Huh JH, Kim WJ, Kim KM, Cha IH, Rhee Y

  • KMID: 2314119
  • Osteoporosis.
  • 2012 Aug;10(2):76-81.
Bisphosphonates are the most widely used medications for treating high bone turnover osteoporosis, Paget's disease of bone, multiple myeloma and metastatic carcinomas, etc. However, a destructive complication of bisphosphonate-related osteonecrosis...
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Clinical study of correlation between C-terminal cross-linking telopeptide of type I collagen and risk assessment, severity of disease, healing after early surgical intervention in patients with bisphophonate-related osteonecrosis of the jaws

Song JW, Kim KH, Song JM, Chun BD, Kim YD, Kim UK, Shin SH

INTRODUCTION: The utility of the C-terminal cross-linking telopeptide test (CTX) as a method for staging Bisphosphonate-related osteonecrosis of the jaws (BRONJ) and its healing process was examined. MATERIALS AND METHODS: A...
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Clinical Study of Bisphosphonate-Induced Osteonecrosis of Mandibular and Maxillary Bone

Joeng HR, Kim TW, Lee JK, Song SI

  • KMID: 1474212
  • J Korean Assoc Oral Maxillofac Surg.
  • 2009 Oct;35(5):353-360.
Bisphosphonates are compounds widely used in the treatment of various metabolic and malignant bone disease. Recently, an association between bisphosphonate use and a rare dental condition termed 'osteonecrosis of the...
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