- Erratum to "Potential Role of Dietary Salmon Nasal Cartilage Proteoglycan on UVB-Induced Photoaged Skin" [Biomol Ther 32(2), 249-260 (2024)]
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Lee HR, Hong SM, Cho K, Kim SH, Ko E, Lee E, Kim HJ, Jeon SY, Do SG, Kim SY
- KMID: 2565702
- Biomol Ther.
- 2025 Mar;33(2):415-415.
- doi: 10.4062/biomolther.2025.001
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- Artesunate Inhibits the Proliferation and Migration of Cutaneous Squamous Cell Carcinoma by Regulating the SLC7A11-GPX4 Pathway via the p300-p53 Axis
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Huang X, Wang W, Zhang S, Li L, Huang J
- KMID: 2565697
- Biomol Ther.
- 2025 Mar;33(2):365-377.
- doi: 10.4062/biomolther.2024.156
The incidence of cutaneous squamous cell carcinoma (CSCC) is increasing rapidly. This study discussed the effects of artesunate (ART) on CSCC cell proliferation and migration via the solute carrier family... -
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- Quercetin-3-Methyl Ether Induces Early Apoptosis to Overcome HRV1B Immune Evasion, Suppress Viral Replication, and Mitigate Inflammatory Pathogenesis
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Song JH, Mun SH, Mishra S, Kim SR, Yang H, Choi SS, Kim MJ, Kim DY, Cho S, Ham Y, Choi HJ, Baek WJ, Kwon YS, Chang JH, Ko HJ
- KMID: 2565699
- Biomol Ther.
- 2025 Mar;33(2):388-398.
- doi: 10.4062/biomolther.2024.204
Human rhinovirus (HRV) causes the common cold and exacerbates chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease. Despite its significant impact on public health, there are currently... -
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- Resveratrol from Peanut Sprout Extract Promotes NK Cell Activation and Antitumor Activity
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Chung H, Bak SH, Shin E, Park T, Kim J, Jeong H, Jung H, Yoon SR, Noh JY
- KMID: 2565696
- Biomol Ther.
- 2025 Mar;33(2):355-364.
- doi: 10.4062/biomolther.2024.133
Natural killer (NK) cells are innate immune cells that are crucial for anticancer activity and have been developed as an immune cell therapy for leukemia. However, their limited effectiveness against... -
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- Primed Mesenchymal Stem Cells by IFN-γγ and IL-1β Ameliorate Acute Respiratory Distress Syndrome through Enhancing Homing Effect and Immunomodulation
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Kong T, Seo SK, Han YS, Seo WM, Kim B, Kim J, Cho YJ, Lee S, Kang KS
- KMID: 2565692
- Biomol Ther.
- 2025 Mar;33(2):311-324.
- doi: 10.4062/biomolther.2025.004
Acute Respiratory Distress Syndrome (ARDS) is a severe condition characterized by extensive lung inflammation and increased alveolar-capillary permeability, often triggered by infections or systemic inflammatory responses. Mesenchymal stem cells (MSCs)-based... -
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- Pro-Oxidative and Inflammatory Actions of Extracellular Hemoglobin and Heme: Molecular Events and Implications for Alzheimer’s and Parkinson Disease
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Campomayor NB, Kim HJ, Kim M
- KMID: 2565686
- Biomol Ther.
- 2025 Mar;33(2):235-248.
- doi: 10.4062/biomolther.2024.224
Hemoglobin (Hb) and heme, which are typically confined within red blood cells (RBCs), are essential for intravascular transport of gases and nutrients. However, these molecules acquire secondary functions upon exposure... -
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- Piperine Regulates Melanogenesis through ERK Activation and Proteasomal Degradation of MITF
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Lee JH, Lee J, Dej-adisai S, Hwang JS
- KMID: 2565701
- Biomol Ther.
- 2025 Mar;33(2):408-414.
- doi: 10.4062/biomolther.2024.065
Melanin is a bio-pigment molecule synthesized by melanocytes. Its role is to shield the skin from ultraviolet radiation. Nonetheless, aberrant melanin production, whether excessive or deficient, can lead to conditions... -
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- An Amphibians-Derived Protein Provides Novel Biotherapeutics for Various Wounds Treatment
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Chen HR, Zhou N, Liu YD, Peng LH
- KMID: 2565700
- Biomol Ther.
- 2025 Mar;33(2):399-407.
- doi: 10.4062/biomolther.2024.096
Acute burns and chronic wounds frequently fail to heal owing to various reasons. Most drugs currently used for wound therapy in clinical practice have notable drawbacks, making their application a... -
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- Isoliquiritigenin Induces Apoptosis via ROS-Mediated Inhibition of p38/mTOR/STAT3 Pathway in Human Melanoma Cells
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Kwon MJ, Raut PK, Jang JH, Chun KS
- KMID: 2565698
- Biomol Ther.
- 2025 Mar;33(2):378-387.
- doi: 10.4062/biomolther.2024.118
Isoliquiritigenin (ISL), a phenolic compound derived from licorice, exhibits various biological activities, including anti-inflammatory, anti-viral, anti-tumor, and antioxidant effects. However, the molecular mechanisms underlying its anti-cancer effects are not well... -
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- Licochalcone D Exerts Antitumor Activity in Human Colorectal Cancer Cells by Inducing ROS Generation and Phosphorylating JNK and p38 MAPK
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Lee SO, Joo SH, Cho SS, Yoon G, Choi YH, Park JW, Weon KY, Shim JH
- KMID: 2565695
- Biomol Ther.
- 2025 Mar;33(2):344-354.
- doi: 10.4062/biomolther.2024.123
Anticancer activities of Licochalcone D (LCD) in human colorectal cancer (CRC) cells HCT116 and oxaliplatin-resistant HCT116 (HCT116-OxR) were determined. Cell viability assay and soft agar assay were used to analyze... -
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- Daurisoline Inhibits Progression of Triple-Negative Breast Cancer by Regulating the γγ-Secretase/Notch Axis
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Zhan X, Chen X, Feng M, Yao K, Yang K, Jia H
- KMID: 2565694
- Biomol Ther.
- 2025 Mar;33(2):331-343.
- doi: 10.4062/biomolther.2024.131
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is challenging to treat and lacks targeted therapeutic drugs in the clinic. Natural active ingredients provide promising opportunities for... -
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- Galangin Regulates Mucin 5AC Gene Expression via the Nuclear Factor-κB Inhibitor α/Nuclear Factor-κB p65 Pathway in Human Airway Epithelial Cells
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Hossain R, Lee HJ, Lee CJ
- KMID: 2565693
- Biomol Ther.
- 2025 Mar;33(2):325-330.
- doi: 10.4062/biomolther.2024.140
In this study, we investigated the effects of the flavonoid galangin on the expression of the mucin 5AC (MUC5AC) gene in airway cells. Human pulmonary epithelial NCI-H292 cells were pretreated... -
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- Isorhamnetin Alleviates Inflammation-Induced Crosstalk between Kynurenine Pathway and Gut Microbiota in Depressed Mice
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Xu M, He W, Yan K, Gao X, Li J, Xu D, Xiao J, Yan T
- KMID: 2565691
- Biomol Ther.
- 2025 Mar;33(2):297-310.
- doi: 10.4062/biomolther.2024.061
Depression is a widespread psychiatric disorder with complex pathogenesis and unsatisfactory therapeutic effects. As a native flavonoid, Isorhamnetin (ISO) has been deemed to exert neuroprotective effects by antioxidation and regulation... -
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- Neuroprotective Effect of β-Lapachone against Glutamate-Induced Injury in HT22 Cells
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Lee HR, Jee HJ, Jung YS
- KMID: 2565690
- Biomol Ther.
- 2025 Mar;33(2):286-296.
- doi: 10.4062/biomolther.2024.241
While glutamate, a key neurotransmitter in the central nervous system, is fundamental to neuronal viability and normal brain function, its excessive accumulation leads to oxidative stress, contributing to neuronal damage... -
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- Structure-Activity Relationship of NMDA Receptor Ligands and Their Activities on the ERK Activation through Metabotropic Signaling Pathway
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Kundu D, Wang M, Paudel S, Wang S, Jang CG, Kim KM
- KMID: 2565689
- Biomol Ther.
- 2025 Mar;33(2):278-285.
- doi: 10.4062/biomolther.2024.216
The N-methyl-D-aspartate receptor (NMDA-R) subunit GluN2B is abundantly expressed in brain regions critical for synaptic plasticity and cognitive processes. This study investigated the structure-activity relationships (SAR) of NMDA-R ligands using... -
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- A Novel Histone Deacetylase 6 Inhibitor, 4-FHA, Improves Scopolamine-Induced Cognitive and Memory Impairment in Mice
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Seo JY, Kim J, Ko YH, Lee BR, Hur KH, Jung YH, Park HJ, Lee SY, Jang CG
- KMID: 2565688
- Biomol Ther.
- 2025 Mar;33(2):268-277.
- doi: 10.4062/biomolther.2024.110
Although histone deacetylase 6 (HDAC6) is considered a therapeutic target for Alzheimer’s disease (AD), its role in cholinergic dysfunction in AD patients remains unclear. This study investigated the effects of... -
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- Allergy Inhibition Using Naturally Occurring Compounds Targeting Thymic Stromal Lymphopoietin Pathways: a Comprehensive Review
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Vinh LB, Lee KS, Han YK, Kim YJ, Kim S, Shah AB, Byun Y, Lee KY
- KMID: 2565687
- Biomol Ther.
- 2025 Mar;33(2):249-267.
- doi: 10.4062/biomolther.2024.177
Naturally occurring compounds have widely been applied to treat diverse pharmacological effects, including asthma, allergic diseases, antioxidants, inflammation, antibiotics, and cancer. Recent research has revealed the essential role of the... -
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