- Engineered T Cell Receptor for Cancer Immunotherapy
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Lee SW, Lee HM
- KMID: 2557190
- Biomol Ther.
- 2024 Jul;32(4):424-431.
- doi: 10.4062/biomolther.2023.197
Among the therapeutic strategies in cancer immunotherapy—such as immune-modulating antibodies, cancer vaccines, or adoptive T cell transfer—T cells have been an attractive target due to their cytotoxicity toward tumor cells... -
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- Structural Insights into the Interaction of Terpenoids with Streptomyces avermitilis CYP107P2
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Jeong E, Kim V, Kim C, Lee Yb, Kim D
- KMID: 2557196
- Biomol Ther.
- 2024 Jul;32(4):474-480.
- doi: 10.4062/biomolther.2024.045
Streptomyces avermitilis genome includes 33 genes encoding monooxygenation-catalyzing cytochrome P450 enzymes. We investigated the structure of CYP107P2 and its interactions with terpenoid compounds. The recombinant CYP107P2 protein was expressed in... -
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- Selonsertib, an ASK1 Inhibitor, Ameliorates Ovalbumin-Induced Allergic Asthma during Challenge and Sensitization Periods
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Han SY, Im DS
- KMID: 2557193
- Biomol Ther.
- 2024 Jul;32(4):451-459.
- doi: 10.4062/biomolther.2023.203
Apoptosis signal-regulating kinase 1 (ASK1) is an upstream signaling molecule in oxidative stress-induced responses. Because oxidative stress is involved in asthma pathogenesis, ASK1 gene deficiency was investigated in animal models... -
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- Anti-Melanogenic Activity of Undecylprodigiosin, a Red Pigment Isolated from a Marine Streptomyces sp. SNA-077
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Lee C, Park JM, Hillman PF, Yoo M, Kim HY, Lee CS, Nam SJ
- KMID: 2557198
- Biomol Ther.
- 2024 Jul;32(4):492-498.
- doi: 10.4062/biomolther.2023.208
Bioassay and HPLC-UV guided fractionations of the crude extract of marine-derived Streptomyces sp. SNA-077 have led to the isolation of a red pigment, undecylprodigiosin (1). The chemical structure of undecylprodigiosin... -
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- Gut Microbiota Metabolite Messengers in Brain Function and Pathology at a View of Cell Type-Based Receptor and Enzyme Reaction
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Lee B, Lee SM, Song JW, Choi JW
- KMID: 2557172
- Biomol Ther.
- 2024 Jul;32(4):403-423.
- doi: 10.4062/biomolther.2024.009
The human gastrointestinal (GI) tract houses a diverse microbial community, known as the gut microbiome comprising bacteria, viruses, fungi, and protozoa. The gut microbiome plays a crucial role in maintaining... -
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- Elafibranor PPARα/δ Dual Agonist Ameliorates Ovalbumin-Induced Allergic Asthma
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Lee YE, Im DS
- KMID: 2557194
- Biomol Ther.
- 2024 Jul;32(4):460-466.
- doi: 10.4062/biomolther.2023.194
Asthma is characterized by chronic inflammation and respiratory tract remodeling. Peroxisome proliferator-activated receptors (PPARs) play important roles in the pathogenesis and regulation of chronic inflammatory processes in asthma. The role... -
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- Structure–Activity Relationship and Functional Evaluation of Cannabinoid Type-1 Receptor
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Wang S, Tian X, Paudel S, Ghil S, Jang CG, Kim KM
- KMID: 2557192
- Biomol Ther.
- 2024 Jul;32(4):442-450.
- doi: 10.4062/biomolther.2023.205
The type-1 cannabinoid receptor (CB 1R) is a potential therapeutic target in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. Owing to their structural diversity, it is not easy... -
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- Anti-Inflammatory Activities of (+)-Afzelechin against Lipopolysaccharide-Induced Inflammation
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Lee IC, Bae JS
- KMID: 2557195
- Biomol Ther.
- 2024 Jul;32(4):467-473.
- doi: 10.4062/biomolther.2023.204
In this study, we investigated the potential protective effects of (+)-afzelechin (AZC), a natural compound that is derived from Bergenia ligulata, on lipopolysaccharide (LPS)-induced inflammatory responses. AZC is known to... -
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- Inhibitory Action of 1,3,5-Trihydroxybenzene on UVB-Induced NADPH Oxidase 4 through AMPK and JNK Signaling Pathways
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Lim C, Piao MJ, Kang KA, Fernando PDSM, Herath HMUL, Kim DW, Yi JM, Choi YH, Hyun JW
- KMID: 2557199
- Biomol Ther.
- 2024 Jul;32(4):499-507.
- doi: 10.4062/biomolther.2024.054
Specific sensitivity of the skin to ultraviolet B (UVB) rays is one of the mechanisms responsible for widespread skin damage. This study tested whether 1,3,5-trihydroxybenzene (THB), a compound abundant in... -
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- Analysis of SARS-CoV-2 Mutations after Nirmatrelvir Treatment in a Lung Cancer Xenograft Mouse Model
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Kang BM, Kim D, Kim J, Baek K, Park S, Shin HE, Lee MH, Kim M, Kim S, Lee Y, Kwon HJ
- KMID: 2557197
- Biomol Ther.
- 2024 Jul;32(4):481-491.
- doi: 10.4062/biomolther.2023.195
Paxlovid is the first approved oral treatment for coronavirus disease 2019 and includes nirmatrelvir, a protease inhibitor targeting the main protease (Mpro ) of SARS-CoV-2, as one of the key... -
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- Extracellular Vesicles Derived from Adipose Stem Cells Alleviate Systemic Sclerosis by Inhibiting TGF-β Pathway
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Kim E, Kim HK, Sul JH, Lee J, Baek SH, Cho Y, Han J, Kim J, Park S, Park JH, Cho YW, Jo DG
- KMID: 2557191
- Biomol Ther.
- 2024 Jul;32(4):432-441.
- doi: 10.4062/biomolther.2023.191
Systemic sclerosis is an autoimmune disease characterized by inflammatory reactions and fibrosis. Myofibroblasts are considered therapeutic targets for preventing and reversing the pathogenesis of fibrosis in systemic sclerosis. Although the... -
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