- Current Development Status of Cytokines for Cancer Immunotherapy
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Song K
- KMID: 2550254
- Biomol Ther.
- 2024 Jan;32(1):13-24.
- doi: 10.4062/biomolther.2023.196
Cytokines influence the overall cancer immune cycle by triggering tumor antigen expression, antigen presenting, immune cell priming and activation, effector immune cell recruitment and infiltration to cancer, and cancer killing... -
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- Anti-Inflammatory Herbal Extracts and Their Drug Discovery Perspective in Atopic Dermatitis
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Lee JW, Kim EN, Jeong GS
- KMID: 2550255
- Biomol Ther.
- 2024 Jan;32(1):25-37.
- doi: 10.4062/biomolther.2023.102
Atopic dermatitis (AD) is an allergic disorder characterized by skin inflammation. It is well known that the activation of various inflammatory cells and the generation of inflammatory molecules are closely... -
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- Immunological Mechanisms in Cutaneous Adverse Drug Reactions
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Lee AY
- KMID: 2550253
- Biomol Ther.
- 2024 Jan;32(1):1-12.
- doi: 10.4062/biomolther.2023.170
Adverse drug reactions (ADRs) are an inherent aspect of drug use. While approximately 80% of ADRs are predictable, immune system-mediated ADRs, often unpredictable, are a noteworthy subset. Skin-related ADRs, in... -
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- Exploring the Potential of Rosemary Derived Compounds (Rosmarinic and Carnosic Acids) as Cancer Therapeutics: Current Knowledge and Future Perspectives
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Sirajudeen F, Malhab LJB, Bustanji Y, Shahwan M, Alzoubi KH, Semreen MH, Taneera J, El-Huneidi W, Abu-Gharbieh E
- KMID: 2550256
- Biomol Ther.
- 2024 Jan;32(1):38-55.
- doi: 10.4062/biomolther.2023.054
Cancer is a global health challenge with high morbidity and mortality rates. However, conventional cancer treatment methods often have severe side effects and limited success rates. In the last decade,... -
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- Biased Dopamine D2 Receptors Exhibit Distinct Intracellular Trafficking Properties and ERK Activation in Different Subcellular Domains
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Wang S, Peng L, Kim KM
- KMID: 2550257
- Biomol Ther.
- 2024 Jan;32(1):56-64.
- doi: 10.4062/biomolther.2023.033
Biased signaling or functional selectivity refers to the ability of an agonist or receptor to selectively activate a subset of transducers such as G protein and arrestin in the case... -
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- Bortezomib Is Toxic but Induces Neurogenesis and Inhibits TUBB3 Degradation in Rat Neural Stem Cells
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Sohn SY, San TT, Kim J, Kim HJ
- KMID: 2550258
- Biomol Ther.
- 2024 Jan;32(1):65-76.
- doi: 10.4062/biomolther.2023.134
Bortezomib (BTZ) is a proteasome inhibitor used to treat multiple myeloma (MM). However, the induction of peripheral neuropathy is one of the major concerns in using BTZ to treat MM.... -
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- Intermittent Fasting Modulates Immune Response by Generating Tregs via TGF-β Dependent Mechanisms in Obese Mice with Allergic Contact Dermatitis
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Han SC, Kang JI, Choi YK, Boo HJ, Yoon WJ, Kang HK, Yoo ES
- KMID: 2550265
- Biomol Ther.
- 2024 Jan;32(1):136-145.
- doi: 10.4062/biomolther.2023.053
People with obesity maintain low levels of inflammation; therefore, their exposure to foreign antigens can trigger an excessive immune response. In people with obesity or allergic contact dermatitis (ACD), symptoms... -
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- Doxorubicin Attenuates Free Fatty Acid-Induced Lipid Accumulation via Stimulation of p53 in HepG2 Cells
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Yun C, Kim SH, Kwon D, Byun MR, Chung KW, Lee J, Jung YS
- KMID: 2550261
- Biomol Ther.
- 2024 Jan;32(1):94-103.
- doi: 10.4062/biomolther.2023.200
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive accumulation of fat in the liver, and there is a global increase in its incidence owing to changes in lifestyle and... -
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- Therapeutic Effects of (+)-Afzelechin on Particulate Matter-Induced Pulmonary Injury
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Cho S, Park YJ, Bae JS
- KMID: 2550268
- Biomol Ther.
- 2024 Jan;32(1):162-169.
- doi: 10.4062/biomolther.2023.187
Particulate matter (PM) constitutes a hazardous blend of organic and inorganic particles that poses health risks. Inhalation of fine airborne PM with a diameter of ≤ 2.5 μm (PM2.5 )... -
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- Effects of Corticosterone on Beta-Amyloid-Induced Cell Death in SH-SY5Y Cells
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Do BK, Jang JH, Park GH
- KMID: 2550259
- Biomol Ther.
- 2024 Jan;32(1):77-83.
- doi: 10.4062/biomolther.2023.133
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by neuronal cell death and memory impairment. Corticosterone (CORT) is a glucocorticoid hormone produced by the hypothalamic-pituitary-adrenal axis in response to a... -
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- Association between LEPR Genotype and Gut Microbiome in Healthy Non-Obese Korean Adults
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Cha YJ, Chang IA, Jin EH, Song JH, Hong JH, Jung JG, Sunwoo J
- KMID: 2550266
- Biomol Ther.
- 2024 Jan;32(1):146-153.
- doi: 10.4062/biomolther.2023.116
The LEPR (leptin receptor) genotype is associated with obesity. Gut microbiome composition differs between obese and nonobese adults. However, the impact of LEPR genotype on gut microbiome composition in humans... -
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- Antiproliferative Activity of Piceamycin by Regulating Alpha-Actinin-4 in Gemcitabine-Resistant Pancreatic Cancer Cells
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Lee JH, Choi JH, Lee KM, Lee MW, Ku JL, Oh DC, Shin YH, Kim DH, Cho IR, Paik WH, Ryu JK, Kim YT, Lee SH, Lee SK
- KMID: 2550264
- Biomol Ther.
- 2024 Jan;32(1):123-135.
- doi: 10.4062/biomolther.2023.109
Although gemcitabine-based regimens are widely used as an effective treatment for pancreatic cancer, acquired resistance to gemcitabine has become an increasingly common problem. Therefore, a novel therapeutic strategy to treat... -
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- Rosmarinic Acid Inhibits Ultraviolet B-Mediated Oxidative Damage via the AKT/ERK-NRF2-GSH Pathway In Vitro and In Vivo
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Piao MJ, Fernando PMDJ, Kang KA, Fernando PDSM, Herath HMUL, Kim YR, Hyun JW
- KMID: 2550260
- Biomol Ther.
- 2024 Jan;32(1):84-93.
- doi: 10.4062/biomolther.2023.179
Rosmarinic acid (RA) is a phenolic ester that protects human keratinocytes against oxidative damage induced by ultraviolet B (UVB) exposure, however, the mechanisms underlying its effects remain unclear. This study... -
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- Effect of Various Pathological Conditions on Nitric Oxide Level and L-Citrulline Uptake in Motor Neuron-Like (NSC-34) Cell Lines
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Gautam S, Latif S, Kang YS
- KMID: 2550267
- Biomol Ther.
- 2024 Jan;32(1):154-161.
- doi: 10.4062/biomolther.2023.110
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder that causes progressive paralysis. L-Citrulline is a nonessential neutral amino acid produced by L-arginine via nitric oxide synthase (NOS). According... -
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- Contribution of HSP90 Cleavage to the Cytotoxic Effect of Suberoylanilide Hydroxamic Acid In Vivo and the Involvement of TXNIP in HSP90 Cleavage
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Park S, Kim D, Jung H, Choi IP, Kwon HJ, Lee Y
- KMID: 2550263
- Biomol Ther.
- 2024 Jan;32(1):115-122.
- doi: 10.4062/biomolther.2023.104
Heat shock protein (HSP) 90 is expressed in most living organisms, and several client proteins of HSP90 are necessary for cancer cell survival and growth. Previously, we found that HSP90... -
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- Licochalcone C Inhibits the Growth of Human Colorectal Cancer HCT116 Cells Resistant to Oxaliplatin
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Lee SO, Joo SH, Lee JY, Kwak AW, Kim KT, Cho SS, Yoon G, Choi YH, Park JW, Shim JH
- KMID: 2550262
- Biomol Ther.
- 2024 Jan;32(1):104-114.
- doi: 10.4062/biomolther.2023.167
Licochalcone C (LCC; PubChem CID:9840805), a chalcone compound originating from the root of Glycyrrhiza inflata, has shown anticancer activity against skin cancer, esophageal squamous cell carcinoma, and oral squamous cell... -
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