- Sex Differences in the Preventive Effect of Cardiovascular and Metabolic Therapeutics on Dementia
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Choi SA, Jee HJ, Bormate KJ, Kim Y, Jung YS
- KMID: 2547491
- Biomol Ther.
- 2023 Nov;31(6):583-598.
- doi: 10.4062/biomolther.2023.115
Dementia is a clinical syndrome characterized by progressive impairment of cognitive and functional abilities. As currently applied treatments for dementia can only delay the progression of dementia and cannot fundamentally... -
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- Aquaporin-3 Downregulation in Vitiligo Keratinocytes Increases Oxidative Stress of Melanocytes
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Kim NH, Kim HJ, Lee AY
- KMID: 2547497
- Biomol Ther.
- 2023 Nov;31(6):648-654.
- doi: 10.4062/biomolther.2023.112
Oxidative stress-induced melanocyte apoptosis is linked to the immune system and plays a critical role in the pathogenesis of vitiligo. Aquaporin-3 (AQP3), which is downregulated in vitiligo keratinocytes, regulates intracellular... -
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- Domperidone Exerts Antitumor Activity in Triple-Negative Breast Cancer Cells by Modulating Reactive Oxygen Species and JAK/STAT3 Signaling
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Shakya R, Byun MR, Joo SH, Chun KS, Choi JS
- KMID: 2547502
- Biomol Ther.
- 2023 Nov;31(6):692-699.
- doi: 10.4062/biomolther.2023.173
The lack of molecular targets hampers the treatment of triple-negative breast cancer (TNBC). In this study, we determined the cytotoxicity of domperidone, a dopamine D2 receptor (DRD2) antagonist in human... -
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- Stimulatory Anticancer Effect of Resveratrol Mediated by G Protein-Coupled Estrogen Receptor in Colorectal Cancer
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Kim N, Kwon J, Shin US, Jung J
- KMID: 2547498
- Biomol Ther.
- 2023 Nov;31(6):655-660.
- doi: 10.4062/biomolther.2023.072
Colorectal cancer (CRC) is one of the most high-risk cancers; however, it has been suggested that estrogen signaling in CRC could have a protective effect. Therefore, we focused on the... -
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- Alisol B 23-Acetate Ameliorates Ovalbumin-Induced Allergic Asthma during Sensitization and Challenge Periods
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Nam KH, Im DS
- KMID: 2547493
- Biomol Ther.
- 2023 Nov;31(6):611-618.
- doi: 10.4062/biomolther.2023.032
Rhizome of Alisma orientale has been used as a traditional medicine for treating kidney diseases in East Asian countries. Its inhibitory effects on hypersensitivity responses have been reported for methanol... -
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- The Effect of γ-Aminobutyric Acid Intake on UVB- Induced Skin Damage in Hairless Mice
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Zhao H, Park B, Kim MJ, Hwang SH, Kim TJ, Kim SU, Kwon I, Hwang JS
- KMID: 2547496
- Biomol Ther.
- 2023 Nov;31(6):640-647.
- doi: 10.4062/biomolther.2023.085
The skin, the largest organ in the body, undergoes age-related changes influenced by both intrinsic and extrinsic factors. The primary external factor is photoaging which causes hyperpigmentation, uneven skin surface,... -
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- A Novel Role of Hyaluronic Acid and Proteoglycan Link Protein 1 (HAPLN1) in Delaying Vascular Endothelial Cell Senescence
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Zhou D, Jang JM, Yang G, Ha HC, Fu Z, Kim DK
- KMID: 2547495
- Biomol Ther.
- 2023 Nov;31(6):629-639.
- doi: 10.4062/biomolther.2023.096
Cardiovascular diseases (CVDs) are the most common cardiovascular system disorders. Cellular senescence is a key mechanism associated with dysfunction of aged vascular endothelium. Hyaluronic acid and proteoglycan link protein 1... -
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- Licochalcone D Inhibits Skin Epidermal Cells Transformation through the Regulation of AKT Signaling Pathways
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Hwang SY, Wi K, Yoon G, Lee CJ, Lee SI, Jung Jg, Jeong HW, Kim JS, Choi CH, Na CS, Shim JH, Lee MH
- KMID: 2547501
- Biomol Ther.
- 2023 Nov;31(6):682-691.
- doi: 10.4062/biomolther.2023.162
Cell transformation induced by epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) is a critical event in cancer initiation and progression, and understanding the underlying mechanisms is essential for the development... -
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- Diagnostic Role of Bile Pigment Components in Biliary Tract Cancer
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Ahn KS, Kang KJ, Kim YH, Kim TS, Cho KB, Kim HS, Baek WK, Suh SI, Han JY
- KMID: 2547500
- Biomol Ther.
- 2023 Nov;31(6):674-681.
- doi: 10.4062/biomolther.2023.010
Bile pigment, bilirubin, and biliverdin concentrations may change as a results of biliary tract cancer (BTC) altering the mechanisms of radical oxidation and heme breakdown. We explored whether changes in... -
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- Synergistic Renoprotective Effect of Melatonin and Zileuton by Inhibition of Ferroptosis via the AKT/mTOR/NRF2 Signaling in Kidney Injury and Fibrosis
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Jung KH, Kim SE, Go HG, Lee YJ, Park MS, Ko S, Han BS, Yoon YC, Cho YJ, Lee P, Lee SH, Kim K, Hong SS
- KMID: 2547492
- Biomol Ther.
- 2023 Nov;31(6):599-610.
- doi: 10.4062/biomolther.2023.062
According to recent evidence, ferroptosis is a major cell death mechanism in the pathogenesis of kidney injury and fibrosis. Despite the renoprotective effects of classical ferroptosis inhibitors, therapeutic approaches targeting kidney... -
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- Licochalcone H Targets EGFR and AKT to Suppress the Growth of Oxaliplatin -Sensitive and -Resistant Colorectal Cancer Cells
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Lee SO, Lee MH, Kwak AW, Lee JY, Yoon G, Joo SH, Choi YH, Park JW, Shim JH
- KMID: 2547499
- Biomol Ther.
- 2023 Nov;31(6):661-673.
- doi: 10.4062/biomolther.2023.155
Treatment of colorectal cancer (CRC) has always been challenged by the development of resistance. We investigated the antiproliferative activity of licochalcone H (LCH), a regioisomer of licochalcone C derived from... -
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- Effect of Prunetin on Streptozotocin-Induced Diabetic Nephropathy in Rats - a Biochemical and Molecular Approach
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Samy JVRA, Kumar N, Singaravel S, Krishnamoorthy R, Alshuniaber MA, Gatasheh MK, Venkatesan A, Natesan V, Kim SJ
- KMID: 2547494
- Biomol Ther.
- 2023 Nov;31(6):619-628.
- doi: 10.4062/biomolther.2023.068
In the modern era, chronic kidney failure due to diabetes has spread across the globe. Prunetin (PRU), a component of herbal medicines, has a broad variety of pharmacological activities; these... -
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