- Drug Discovery Perspectives of Antisense Oligonucleotides
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Kim Y
- KMID: 2541783
- Biomol Ther.
- 2023 May;31(3):241-252.
- doi: 10.4062/biomolther.2023.001
The era of innovative RNA therapies using antisense oligonucleotides (ASOs), siRNAs, and mRNAs is beginning. Since the emergence of the concept of ASOs in 1978, it took more than 20... -
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- Inhibition of DNMT3B and PI3K/AKT/mTOR and ERK Pathways as a Novel Mechanism of Volasertib on Hypomethylating Agent-Resistant Cells
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Choi EJ, Koo BK, Hur EH, Moon JH, Kim JY, Park HS, Choi Y, Lee KH, Lee JH, Choi EK, Lee JH
- KMID: 2541791
- Biomol Ther.
- 2023 May;31(3):319-329.
- doi: 10.4062/biomolther.2022.117
Resistance to hypomethylating agents (HMAs) in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) is a concerning problem. Polo-like kinase 1 (PLK1) is a key cell cycle modulator and is... -
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- Differences in Neurotransmitters Level as Biomarker on Sleep Effects in Dementia Patients with Insomnia after Essential Oils Treatment
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Lee KB, Latif S, Kang YS
- KMID: 2541788
- Biomol Ther.
- 2023 May;31(3):298-305.
- doi: 10.4062/biomolther.2023.014
This study aimed to examine the effects of several essential oils on insomnia in dementia patients following transdermal treatment (aromatherapy). The mean change rates (%) of sleep biomarkers were compared... -
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- A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment
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Chiu YJ, Teng YS, Chen CM, Sun YC, Hsieh-Li HM, Chang KH, Lee-Chen GJ
- KMID: 2541787
- Biomol Ther.
- 2023 May;31(3):285-297.
- doi: 10.4062/biomolther.2022.136
Alzheimer’s disease (AD) is a neurodegenerative disease with progressive memory loss and the cognitive decline. AD is mainly caused by abnormal accumulation of misfolded amyloid β (Aβ), which leads to... -
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- Inactivation of Mad2B Enhances Apoptosis in Human Cervical Cancer Cell Line upon Cisplatin-Induced DNA Damage
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Kim JH, Kim HR, Patel R
- KMID: 2541793
- Biomol Ther.
- 2023 May;31(3):340-349.
- doi: 10.4062/biomolther.2022.130
Mad2B (Mad2L2), the human homolog of the yeast Rev7 protein, is a regulatory subunit of DNA polymerase ζ that shares sequence similarity with the mitotic checkpoint protein Mad2A. Previous studies... -
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- Macakurzin C Derivatives as a Novel Pharmacophore for Pan-Peroxisome Proliferator-Activated Receptor Modulator
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Ko H, An S, Jang H, Ahn S, Park IG, Hwang SY, Gong J, Oh S, Kwak SY, Choi WJ, Kim H, Noh M
- KMID: 2541790
- Biomol Ther.
- 2023 May;31(3):312-318.
- doi: 10.4062/biomolther.2022.097
The natural flavonoid macakurzin C (1) exhibited adiponectin biosynthesis-inducing activity during adipogenesis in human bone marrow mesenchymal stem cells and its molecular mechanism was directly associated with a pan-peroxisome proliferator-activated... -
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- Liver Kinase B1 Mediates Its Anti-Tumor Function by Binding to the N-Terminus of Malic Enzyme 3
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Rho SB, Byun HJ, Kim BR, Lee CH
- KMID: 2541792
- Biomol Ther.
- 2023 May;31(3):330-339.
- doi: 10.4062/biomolther.2023.041
Liver kinase B1 (LKB1) is a crucial tumor suppressor involved in various cellular processes, including embryonic development, tumor initiation and progression, cell adhesion, apoptosis, and metabolism. However, the precise mechanisms... -
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- A Bivalent Inactivated Vaccine Prevents Enterovirus 71 and Coxsackievirus A16 Infections in the Mongolian Gerbil
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Yi EJ, Kim YI, Kim SY, Ahn SH, Lee HJ, Suh B, Yu J, Park J, Lee YJ, Jung E, Chang SY
- KMID: 2541794
- Biomol Ther.
- 2023 May;31(3):350-358.
- doi: 10.4062/biomolther.2023.058
Hand-foot-and-mouth disease (HFMD) is a viral infectious disease that occurs in children under 5 years of age. Its main causes are coxsackievirus (CV) and enterovirus (EV). Since there are no... -
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- Meclofenamate Suppresses MUC5AC Mucin Gene Expression by Regulating the NF-kB Signaling Pathway in Human Pulmonary Mucoepidermoid NCI-H292 Cells
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Ryu J, Kim Ki, Hossain R, Lee M, Hong JT, Lee HJ, Lee CJ
- KMID: 2541789
- Biomol Ther.
- 2023 May;31(3):306-311.
- doi: 10.4062/biomolther.2023.035
The current study aimed to reveal the potential effect of meclofenamate, a nonsteroidal anti-inflammatory drug, on the gene expression of airway MUC5AC mucin. Human pulmonary mucoepidermoid NCI-H292 cells were pretreated... -
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- Sinapic Acid Attenuates the Neuroinflammatory Response by Targeting AKT and MAPK in LPS-Activated Microglial Models
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Huang T, Zhao D, Lee S, Keum G, Yang HO
- KMID: 2541786
- Biomol Ther.
- 2023 May;31(3):276-284.
- doi: 10.4062/biomolther.2022.092
Sinapic acid (SA) is a phenolic acid that is widely distributed in fruits and vegetables, which has various bioactivities, such as antidiabetic, anticancer and anti-inflammatory functions. Over-activated microglial is involved... -
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- Exosomes: Nomenclature, Isolation, and Biological Roles in Liver Diseases
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Park SH, Lee EK, Yim J, Lee MH, Lee E, Lee YS, Seo W
- KMID: 2541784
- Biomol Ther.
- 2023 May;31(3):253-263.
- doi: 10.4062/biomolther.2022.161
The biogenesis and biological roles of extracellular vesicles (EVs) in the progression of liver diseases have attracted considerable attention in recent years. EVs are membrane-bound nanosized vesicles found in different... -
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- Efficient Generation of Dopaminergic Neurons from Mouse Ventral Midbrain Astrocytes
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Han JY, Lee EH, Kim SM, Park CH
- KMID: 2541785
- Biomol Ther.
- 2023 May;31(3):264-275.
- doi: 10.4062/biomolther.2022.140
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by tremors, bradykinesia, and rigidity. PD is caused by loss of dopaminergic (DA) neurons in the midbrain substantia nigra (SN) and... -
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