- Caspase Cleavage of Receptor Tyrosine Kinases in the Dependence Receptor Family
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Park GH, Kang YK, Paek SM, Shin CY, Han SY
- KMID: 2544058
- Biomol Ther.
- 2023 Jul;31(4):359-369.
- doi: 10.4062/biomolther.2022.133
Dependence receptors are a group of receptor proteins with shared characteristics of transducing two different signals within cells. They can transduce a positive signal of survival and differentiation in the presence... -
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- NLRP3 Inflammasome as Therapeutic Targets in Inflammatory Diseases
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Prakash AV, Park IH, Park JW, Bae JP, Lee GS, Kang TJ
- KMID: 2544061
- Biomol Ther.
- 2023 Jul;31(4):395-401.
- doi: 10.4062/biomolther.2023.099
Innate immunity is a first line defence system in the body which is for sensing signals of danger such as pathogenic microbes or host-derived signals of cellular stress. Pattern recognition... -
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- Nitric Oxide Signal Transduction and Its Role in Skin Sensitization
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Kim JH, Choi MS
- KMID: 2544060
- Biomol Ther.
- 2023 Jul;31(4):388-394.
- doi: 10.4062/biomolther.2023.101
Nitric oxide (NO) is a signaling molecule that plays a crucial role in numerous cellular physiological processes. In the skin, NO is produced by keratinocytes, fibroblasts, endothelial cells, and immune... -
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- Antigen Delivery Systems: Past, Present, and Future
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Ko HJ, Kim YJ
- KMID: 2544059
- Biomol Ther.
- 2023 Jul;31(4):370-387.
- doi: 10.4062/biomolther.2023.006
The COVID-19 pandemic has increased demand for safe and effective vaccines. Research to develop vaccines against diseases including Middle East respiratory syndrome, Ebolavirus, human immunodeficiency virus, and various cancers would... -
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- 5-Hydroxytryptophan Reduces Levodopa-Induced Dyskinesia via Regulating AKT/mTOR/S6K and CREB/ΔFosB Signals in a Mouse Model of Parkinson’s Disease
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Choi Y, Huh E, Lee S, Kim JH, Park MG, Seo SY, Kim SY, Oh MS
- KMID: 2544062
- Biomol Ther.
- 2023 Jul;31(4):402-410.
- doi: 10.4062/biomolther.2022.141
Long-term administration of levodopa (L-DOPA) to patients with Parkinson’s disease (PD) commonly results in involuntary dyskinetic movements, as is known for L-DOPA-induced dyskinesia (LID). 5-Hydroxytryptophan (5-HTP) has recently been shown... -
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- LKB1/STK11 Tumor Suppressor Reduces Angiogenesis by Directly Interacting with VEGFR2 in Tumorigenesis
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Rho SB, Byun HJ, Kim BR, Lee CH
- KMID: 2544068
- Biomol Ther.
- 2023 Jul;31(4):456-465.
- doi: 10.4062/biomolther.2023.106
Cervical tumors represent a prevalent form of cancer affecting women worldwide; current treatment options involve surgery, radiotherapy, and chemotherapy. Angiogenesis, the process of new blood vessel formation, is a crucial... -
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- Inhibition of Melanosome Transport by Inducing Exon Skipping in Melanophilin
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Kim JY, Han SY, Sung K, Seo JY, Myung CH, Jo CS, Yoon JH, Park JY, Hwang JS
- KMID: 2544069
- Biomol Ther.
- 2023 Jul;31(4):466-472.
- doi: 10.4062/biomolther.2022.167
Exon skipping is an efficient technique to inhibit specific gene expression induced by a short-sequence peptide nucleic acid (PNA). To date, there has been no study on the effects of PNA... -
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- Anti-Fibrotic Effects of DL-Glyceraldehyde in Hepatic Stellate Cells via Activation of ERK-JNK-Caspase-3 Signaling Axis
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Samsuzzaman M, Kim SY
- KMID: 2544065
- Biomol Ther.
- 2023 Jul;31(4):425-433.
- doi: 10.4062/biomolther.2022.131
During liver injury, hepatic stellate cells can differentiate into myofibroblast-like structures, which are more susceptible to proliferation, migration, and extracellular matrix generation, leading to liver fibrosis. Anaerobic glycolysis is associated... -
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- Effect of FTY-720 on Pulmonary Fibrosis in Mice via the TGF-β1 Signaling Pathway and Autophagy
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Jin Y, Liu W, Gao G, Song Y, Liu H, Li L, Zhou J, Yan G, Cui H
- KMID: 2544066
- Biomol Ther.
- 2023 Jul;31(4):434-445.
- doi: 10.4062/biomolther.2022.123
We investigated whether FTY-720 might have an effect on bleomycin-induced pulmonary fibrosis through inhibiting TGF-β1 pathway, and up-regulating autophagy. The pulmonary fibrosis was induced by bleomycin. FTY-720 (1 mg/kg) drug... -
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- αα-Pinene Attenuates Methamphetamine-Induced Conditioned Place Preference in C57BL/6 Mice
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Lee C, Jang JH, Park GH
- KMID: 2544063
- Biomol Ther.
- 2023 Jul;31(4):411-416.
- doi: 10.4062/biomolther.2022.132
Methamphetamine (METH) is a powerful neurotoxic psychostimulant affecting dopamine transporter (DAT) activity and leading to continuous excess extracellular dopamine levels. Despite recent advances in the knowledge on neurobiological mechanisms underlying... -
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- 6-Shogaol, an Active Ingredient of Ginger, Improves Intestinal and Brain Abnormalities in Proteus Mirabilis-Induced Parkinson’s Disease Mouse Model
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Huh E, Choi JG, Choi Y, Ju IG, Noh D, Shin Dy, Kim DH, Park HJ, Oh MS
- KMID: 2544064
- Biomol Ther.
- 2023 Jul;31(4):417-424.
- doi: 10.4062/biomolther.2023.098
Parkinson’s disease (PD) which has various pathological mechanisms, recently, it is attracting attention to the mechanism via microbiome-gut-brain axis. 6-Shogaol, a representative compound of ginger, have been known for improving... -
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- 3-Deoxysappanchalcone Inhibits Cell Growth of Gefitinib-Resistant Lung Cancer Cells by Simultaneous Targeting of EGFR and MET Kinases
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Lee JY, Lee SO, Kwak AW, Chae SB, Cho SS, Yoon G, Kim KT, Choi YH, Lee MH, Joo SH, Park JW, Shim JH
- KMID: 2544067
- Biomol Ther.
- 2023 Jul;31(4):446-455.
- doi: 10.4062/biomolther.2023.070
The mechanistic functions of 3-deoxysappanchalcone (3-DSC), a chalcone compound known to have many pharmacological effects on lung cancer, have not yet been elucidated. In this study, we identified the comprehensive... -
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