- Erratum to "Synthetic Homoisoflavane Derivatives of Cremastranone Suppress Growth of Colorectal Cancer Cells through Cell Cycle Arrest and Induction of Apoptosis" [Biomol. Ther. 30 (2022) 576-584]
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Shin HE, Lee S, Choi Y, Park S, Kwon S, Choi JK, Seo SY, Lee Y
- KMID: 2537590
- Biomol Ther.
- 2023 Jan;31(1):139-139.
- doi: 10.4062/biomolther.2022.005
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- The Trend of Organic Based Nanoparticles in the Treatment of Diabetes and Its Perspectives
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Natesan V, Kim SJ
- KMID: 2537577
- Biomol Ther.
- 2023 Jan;31(1):16-26.
- doi: 10.4062/biomolther.2022.080
Diabetes is an untreatable metabolic disorder characterized by alteration in blood sugar homeostasis, with submucosal insulin therapy being the primary treatment option. This route of drug administration is attributed to... -
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- Thrombin Induced Apoptosis through Calcium-Mediated Activation of Cytosolic Phospholipase A2 in Intestinal Myofibroblasts
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Park MJ, Won JH, Kim DK
- KMID: 2537581
- Biomol Ther.
- 2023 Jan;31(1):59-67.
- doi: 10.4062/biomolther.2022.043
Thrombin is a serine protease that participates in a variety of biological signaling through protease-activated receptors. Intestinal myofibroblasts play central roles in maintaining intestinal homeostasis. In this study, we found... -
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- MS-5, a Naphthalene Derivative, Induces Apoptosis in Human Pancreatic Cancer BxPC-3 Cells by Modulating Reactive Oxygen Species
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Giri S, Park GH, Choi JS, Ma E, Chun KS, Joo SH
- KMID: 2537582
- Biomol Ther.
- 2023 Jan;31(1):68-72.
- doi: 10.4062/biomolther.2022.127
Pancreatic cancer is one of the most fatal cancers with a poor prognosis. Standard chemotherapies have proven largely ineffective because of their toxicity and the development of resistance. Therefore, there... -
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- Enhancing Anti-Cancer Therapy with Selective Autophagy Inhibitors by Targeting Protective Autophagy
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Lee MJ, Park JS, Jo SB, Joe YA
- KMID: 2537576
- Biomol Ther.
- 2023 Jan;31(1):1-15.
- doi: 10.4062/biomolther.2022.153
Autophagy is a process of eliminating damaged or unnecessary proteins and organelles, thereby maintaining intracellular homeostasis. Deregulation of autophagy is associated with several diseases including cancer. Contradictory dual roles of... -
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- Identification of Small GTPases That Phosphorylate IRF3 through TBK1 Activation Using an Active Mutant Library Screen
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Yu JH, Moon EY, Kim J, Koo JH
- KMID: 2537580
- Biomol Ther.
- 2023 Jan;31(1):48-58.
- doi: 10.4062/biomolther.2022.119
Interferon regulatory factor 3 (IRF3) integrates both immunological and non-immunological inputs to control cell survival and death. Small GTPases are versatile functional switches that lie on the very upstream in... -
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- Growth Factors Upregulated by Uric Acid Affect Guanine Deaminase-Induced Melanogenesis
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Kim NH, Lee AY
- KMID: 2537585
- Biomol Ther.
- 2023 Jan;31(1):89-96.
- doi: 10.4062/biomolther.2022.137
Uric acid produced by guanine deaminase (GDA) is involved in photoaging and hyperpigmentation. Reactive oxygen species (ROS) generated by uric acid plays a role in photoaging. However, the mechanism by... -
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- Loganin Prevents Hepatic Steatosis by Blocking NLRP3 Inflammasome Activation
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Jang JH, Yang G, Seok JK, Kang HC, Cho YY, Lee HS, Lee JY
- KMID: 2537579
- Biomol Ther.
- 2023 Jan;31(1):40-47.
- doi: 10.4062/biomolther.2022.077
Activation of the NLRP3 inflammasome is a necessary process to induce fibrosis in nonalcoholic fatty liver disease (NAFLD). Nonalcoholic steatohepatitis (NASH) is a kind of NAFLD that encompasses the spectrum... -
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- Functional Characterization of Drosophila melanogaster CYP6A8 Fatty Acid Hydroxylase
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Lee SA, Kim V, Choi B, Lee H, Chun YJ, Cho KS, Kim D
- KMID: 2537584
- Biomol Ther.
- 2023 Jan;31(1):82-88.
- doi: 10.4062/biomolther.2022.084
Genomic analysis indicated that the genome of Drosophila melanogaster contains more than 80 cytochrome P450 genes. To date, the enzymatic activity of these P450s has not been extensively studied. Here,... -
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- Minoxidil Regulates Aging-Like Phenotypes in Rat Cortical Astrocytes In Vitro
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Bang M, Yang SJ, Ahn T, Han SH, Shin CY, Kwon KJ
- KMID: 2537588
- Biomol Ther.
- 2023 Jan;31(1):116-126.
- doi: 10.4062/biomolther.2022.144
Mainly due to the slanted focus on the mechanism and regulation of neuronal aging, research on astrocyte aging and its modulation during brain aging is scarce. In this study, we... -
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- 6-Shogaol and 10-Shogaol Synergize Curcumin in Ameliorating Proinflammatory Mediators via the Modulation of TLR4/TRAF6/ MAPK and NFκB Translocation
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Zhou X, Al-Khazaleh A, Afzal S, Kao MH(, Münch G, Wohlmuth H, Leach D, Low M, Li CG
- KMID: 2537578
- Biomol Ther.
- 2023 Jan;31(1):27-39.
- doi: 10.4062/biomolther.2022.039
Extensive research supported the therapeutic potential of curcumin, a naturally occurring compound, as a promising cytokinesuppressive anti-inflammatory drug. This study aimed to investigate the synergistic anti-inflammatory and anti-cytokine activities by... -
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- Potential Functional Role of Phenethylamine Derivatives in Inhibiting Dopamine Reuptake: Structure–Activity Relationship
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Kundu D, Zhu A, Kim E, Paudel S, Jang CG, Lee YS, Kim KM
- KMID: 2537587
- Biomol Ther.
- 2023 Jan;31(1):108-115.
- doi: 10.4062/biomolther.2022.047
Numerous psychotropic and addictive substances possess structural features similar to those of β-phenethylamine (β-PEA). In this study, we selected 29 β-PEA derivatives and determined their structure–activity relationship (SAR) to their... -
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- MHY2251, a New SIRT1 Inhibitor, Induces Apoptosis via JNK/p53 Pathway in HCT116 Human Colorectal Cancer Cells
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Kang YJ, Kwon YH, Jang JY, Lee JH, Lee S, Park Y, Moon HR, Chung HY, Kim ND
- KMID: 2537583
- Biomol Ther.
- 2023 Jan;31(1):73-81.
- doi: 10.4062/biomolther.2022.044
Sirtuins (SIRTs) belong to the nicotinamide adenine dinucleotide (NAD+)-dependent class III histone deacetylase family. They are key regulators of cellular and physiological processes, such as cell survival, senescence, differentiation, DNA... -
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- Melatonin Attenuates Mitochondrial Damage in Aristolochic AcidInduced Acute Kidney Injury
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Sun J, Pan J, Liu Q, Cheng J, Tang Q, Ji Y, Cheng K, wang R, Liu L, Wang D, Wu N, Zheng X, Li J, Zhang X, Zhu Z, Ding Y, Zheng F, Li J, Zhang Y, Yuan Y
- KMID: 2537586
- Biomol Ther.
- 2023 Jan;31(1):97-107.
- doi: 10.4062/biomolther.2022.054
Aristolochic acid (AA), extracted from Aristolochiaceae plants, plays an essential role in traditional herbal medicines and is used for different diseases. However, AA has been found to be nephrotoxic and... -
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- Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity
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Lin CH, Hsieh YS, Sun YC, Huang WH, Chen SL, Weng ZK, Lin TH, Wu YR, Chang KH, Huang HJ, Lee GC, Hsieh-Li HM, Lee-Chen GJ
- KMID: 2537589
- Biomol Ther.
- 2023 Jan;31(1):127-138.
- doi: 10.4062/biomolther.2022.035
Glycogen synthase kinase-3β (GSK-3β) is an important serine/threonine kinase that implicates in multiple cellular processes and links with the neurodegenerative diseases including Alzheimer’s disease (AD). In this study, structure-based virtual... -
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