- The Role of Mitochondrial Biogenesis Dysfunction in Diabetic Cardiomyopathy
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Tao LC, Wang Tt, Zheng L, Hua F, Li JJ
- KMID: 2532872
- Biomol Ther.
- 2022 Sep;30(5):399-408.
- doi: 10.4062/biomolther.2021.192
Diabetic cardiomyopathy (DCM) is described as abnormalities of myocardial structure and function in diabetic patients without other well-established cardiovascular factors. Although multiple pathological mechanisms involving in this unique myocardial disorder,... -
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- Involvement of IKK/IkBα/NF-kB p65 Signaling into the Regulative Effect of Engeletin on MUC5AC Mucin Gene Expression in Human Airway Epithelial Cells
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Hossain R, Kim Ki, Li X, Lee HJ, Lee CJ
- KMID: 2532880
- Biomol Ther.
- 2022 Sep;30(5):473-478.
- doi: 10.4062/biomolther.2022.088
In this study, we examined whether engeletin exerts an effect on the gene expression of MUC5AC mucin, in human pulmonary epithelial NCI-H292 cells. The cells were pretreated with engeletin for... -
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- CKD-581 Downregulates Wnt/β-Catenin Pathway by DACT3 Induction in Hematologic Malignancy
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Kim SJ, Kim S, Choi YJ, Kim UJ, Kang KW
- KMID: 2532876
- Biomol Ther.
- 2022 Sep;30(5):435-446.
- doi: 10.4062/biomolther.2022.022
The present study evaluated the anti-cancer activity of histone deacetylase (HDAC)-inhibiting CKD-581 in multiple myeloma (MM) and its pharmacological mechanisms. CKD-581 potently inhibited a broad spectrum of HDAC isozymes. It... -
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- Sinapic Acid Ameliorates REV-ERB α Modulated Mitochondrial Fission against MPTP-Induced Parkinson’s Disease Model
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Lee SB, Yang HO
- KMID: 2532873
- Biomol Ther.
- 2022 Sep;30(5):409-417.
- doi: 10.4062/biomolther.2022.020
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, and accumulating evidence indicates that mitochondrial dysfunction is associated with progressive deterioration in PD patients. Previous studies have shown... -
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- Polyploidization of Hepatocytes: Insights into the Pathogenesis of Liver Diseases
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Kim JY, Choi H, Kim HJ, Jee Y, Noh M, Lee MO
- KMID: 2532871
- Biomol Ther.
- 2022 Sep;30(5):391-398.
- doi: 10.4062/biomolther.2022.070
Polyploidization is a process by which cells are induced to possess more than two sets of chromosomes. Although polyploidization is not frequent in mammals, it is closely associated with development... -
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- Efonidipine Inhibits JNK and NF-κB Pathway to Attenuate Inflammation and Cell Migration Induced by Lipopolysaccharide in Microglial Cells
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Nguyen NM, Duong MTH, Nguyen PL, Bui BP, Ahn HC, Cho J
- KMID: 2532878
- Biomol Ther.
- 2022 Sep;30(5):455-464.
- doi: 10.4062/biomolther.2022.076
Efonidipine, a calcium channel blocker, is widely used for the treatment of hypertension and cardiovascular diseases. In our preliminary study using structure-based virtual screening, efonidipine was identified as a potential... -
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- Anti-Tumor Effect of IDF-11774, an Inhibitor of Hypoxia-Inducible Factor-1, on Melanoma
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Kim NH, Jeong JH, Park YJ, Shin HY, Choi WK, Lee K, Lee AY
- KMID: 2532879
- Biomol Ther.
- 2022 Sep;30(5):465-472.
- doi: 10.4062/biomolther.2022.061
Melanoma is one of the most aggressive skin cancers. Hypoxia contributes to the aggressiveness of melanoma by promoting cancer growth and metastasis. Upregulation of cyclin D1 can promote uncontrolled cell... -
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- Comparative Study of Autophagy in Oxaliplatin-Sensitive and Resistant SNU-C5 Colon Cancer Cells
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Boo SJ, Piao MJ, Kang KA, Zhen AX, Fernando PDSM, Herath HMUL, Lee SJ, Song SE, Hyun JW
- KMID: 2532877
- Biomol Ther.
- 2022 Sep;30(5):447-454.
- doi: 10.4062/biomolther.2022.028
Few studies have evaluated the role of autophagy in the development of oxaliplatin (OXT) resistance in colon cancer cells. In this study, we compared the role of autophagy between SNU-C5... -
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- Bispecific Antibody-Bound T Cells as a Novel Anticancer Immunotherapy
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Cho J, Tae N, Ahn JH, Chang SY, Ko HJ, Kim DH
- KMID: 2532874
- Biomol Ther.
- 2022 Sep;30(5):418-426.
- doi: 10.4062/biomolther.2022.015
Chimeric antigen receptor T (CAR-T) cell therapy is one of the promising anticancer treatments. It shows a high overall response rate with complete response to blood cancer. However, there is... -
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- Abiraterone Acetate Attenuates SARS-CoV-2 Replication by Interfering with the Structural Nucleocapsid Protein
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Kim J, Hwang SY, Kim D, Kim M, Baek K, Kang M, An S, Gong J, Park S, Kandeel M, Lee Y, Noh M, Kwon HJ
- KMID: 2532875
- Biomol Ther.
- 2022 Sep;30(5):427-434.
- doi: 10.4062/biomolther.2022.037
The drug repurposing strategy has been applied to the development of emergency COVID-19 therapeutic medicines. Current drug repurposing approaches have been directed against RNA polymerases and viral proteases. Recently, we... -
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