- Autism-Like Behavioral Phenotypes in Mice Treated with Systemic N-Methyl-D-Aspartate
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Jym Adil K, Gonzales EL, Remonde CG, Boo KJ, Jeon SJ, Shin CY
- KMID: 2529888
- Biomol Ther.
- 2022 May;30(3):232-237.
- doi: 10.4062/biomolther.2021.133
Autism spectrum disorder (ASD) having core characteristics of social interaction problems and repetitive behaviors and interests affects individuals at varying degrees and comorbidities, making it difficult to determine the precise... -
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- Urushiol V Suppresses Cell Proliferation and Enhances Antitumor Activity of 5-FU in Human Colon Cancer Cells by Downregulating FoxM1
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Jeong JH, Ryu JH
- KMID: 2529891
- Biomol Ther.
- 2022 May;30(3):257-264.
- doi: 10.4062/biomolther.2022.008
Colorectal cancer (CRC) is one of the most common malignant tumor. 5-FU is commonly used for the treatment of CRC. However, the development of drug resistance in tumor chemotherapy can... -
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- The Role of Adiponectin in the Skin
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Oh J, Lee Y, Oh SW, Li T, Shin J, Park SH, Lee J
- KMID: 2529887
- Biomol Ther.
- 2022 May;30(3):221-231.
- doi: 10.4062/biomolther.2021.089
Adiponectin (Ad), a 30 kDa molecule, is an anti-diabetic adipokine; although derived from adipose tissue, it performs numerous activities in various other tissues. It binds to its own receptors, namely... -
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- Epithelial-Mesenchymal Transition-Inducing Factors Involved in the Progression of Lung Cancers
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Nam MW, Kim CW, Choi KC
- KMID: 2529886
- Biomol Ther.
- 2022 May;30(3):213-220.
- doi: 10.4062/biomolther.2021.178
Although there have been advances in cancer therapy and surgical improvement, lung cancer has the lowest survival rate (19%) at all stages. This is because most patients are diagnosed with... -
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- Transcriptome Analysis of Long-Term Exposure to Blue Light in Retinal Pigment Epithelial Cells
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Jin HL, Jeong KW
- KMID: 2529895
- Biomol Ther.
- 2022 May;30(3):291-297.
- doi: 10.4062/biomolther.2021.155
Dry age-related macular degeneration (AMD) is a type of progressive blindness that is primarily due to dysfunction and the loss of retinal pigment epithelium (RPE). The accumulation of N-retinylidene-N-retinylethanolamine (A2E),... -
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- Combination Therapy of the Active KRAS-Targeting Antibody inRas37 and a PI3K Inhibitor in Pancreatic Cancer
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Lee JE, Woo MG, Jung KH, Kang YW, Shin SM, Son MK, Fang Z, Yan HH, Park JH, Yoon YC, Kim YS, Hong SS
- KMID: 2529893
- Biomol Ther.
- 2022 May;30(3):274-283.
- doi: 10.4062/biomolther.2021.145
KRAS activating mutations, which are present in more than 90% of pancreatic cancers, drive tumor dependency on the RAS/ mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT signaling pathways. Therefore,... -
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- The Endoplasmic Reticulum Stress Response Mediates Shikonin-Induced Apoptosis of 5-Fluorouracil–Resistant Colorectal Cancer Cells
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Piao MJ, Han X, Kang KA, Madushan Fernando PDS, Lakmini Herath HMU, Hyun JW
- KMID: 2529892
- Biomol Ther.
- 2022 May;30(3):265-273.
- doi: 10.4062/biomolther.2021.118
Resistance to chemotherapeutic drugs is a significant problem in the treatment of colorectal cancer, resulting in low response rates and decreased survival. Recent studies have shown that shikonin, a naphthoquinone... -
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- Direct Contact with Platelets Induces Podoplanin Expression and Invasion in Human Oral Squamous Cell Carcinoma Cells
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Park SY, Lee SK, Lim M, Kim B, Hwang BO, Cho ES, Zhang X, Chun KS, Chung WY, Song NY
- KMID: 2529894
- Biomol Ther.
- 2022 May;30(3):284-290.
- doi: 10.4062/biomolther.2021.167
Oral squamous cell carcinoma (OSCC) is mostly diagnosed at an advanced stage, with local and/or distal metastasis. Thus, locoregional and/or local control of the primary tumor is crucial for a... -
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- Betulin Targets Lipin1/2-Meidated P2X7 Receptor as a Therapeutic Approach to Attenuate Lipid Accumulation and Metaflammation
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Dou JY, Jiang YC, Hu ZH, Yao KC, Yuan MH, Bao XX, Zhou MJ, Liu Y, Li ZX, Lian LH, Nan JX, Wu YL
- KMID: 2529890
- Biomol Ther.
- 2022 May;30(3):246-256.
- doi: 10.4062/biomolther.2021.136
The present study focused on the potential mechanism of betulin (BT), a pentacyclic triterpenoid isolated from the bark of white birch (Betula pubescens), against chronic alcohol-induced lipid accumulation and metaflammation.... -
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- Differentially Expressed Genes in Period 2-Overexpressing Mice Striatum May Underlie Their Lower Sensitivity to Methamphetamine Addiction-Like Behavior
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Sayson LV, Kim M, Jeon SJ, Perez Custodio RJ, Lee HJ, Ortiz DM, Cheong JH, Kim HJ
- KMID: 2529889
- Biomol Ther.
- 2022 May;30(3):238-245.
- doi: 10.4062/biomolther.2021.184
Previous reports have demonstrated that genetic mechanisms greatly mediate responses to drugs of abuse, including methamphetamine (METH). The circadian gene Period 2 (Per2 ) has been previously associated with differential... -
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