- Erratum to "Conformational Dynamics of Sclerostin-LRP6 Complex Analyzed by HDX-MS" [Biomol. Ther. 29 (2021) 527-535]
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Jeong Y, Kim J, Choi HJ, Chung KY
- KMID: 2526824
- Biomol Ther.
- 2022 Mar;30(2):212-212.
- doi: 10.4062/biomolther.2022.002
no abstract available. -
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- The Long Search for Pharmacologically Useful Anti-Inflammatory Flavonoids and Their Action Mechanisms: Past, Present, and Future
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Kim HP
- KMID: 2526813
- Biomol Ther.
- 2022 Mar;30(2):117-125.
- doi: 10.4062/biomolther.2022.004
Flavonoids are known to exert anti-inflammatory effects. Their pharmacological activities have been proved using various in vitro and in vivo models. Although their action spectrum and potencies are not adequate... -
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- Extracellular Concentration of L-Cystine Determines the Sensitivity to System xc - Inhibitors
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Abdullah M, Lee SJ
- KMID: 2526821
- Biomol Ther.
- 2022 Mar;30(2):184-190.
- doi: 10.4062/biomolther.2021.105
Targeting the cystine/glutamate exchange transporter, system xc-, is a promising anticancer strategy that induces ferroptosis, which is a distinct form of cell death mediated by iron-dependent lipid peroxidation. The concentration... -
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- Classification of Mouse Lung Metastatic Tumor with Deep Learning
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Lee HN, Seo HD, Kim EM, Han BS, Kang JS
- KMID: 2526820
- Biomol Ther.
- 2022 Mar;30(2):179-183.
- doi: 10.4062/biomolther.2021.130
Traditionally, pathologists microscopically examine tissue sections to detect pathological lesions; the many slides that must be evaluated impose severe work burdens. Also, diagnostic accuracy varies by pathologist training and experience;... -
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- Natural Compound Shikonin Induces Apoptosis and Attenuates Epithelial to Mesenchymal Transition in Radiation-Resistant Human Colon Cancer Cells
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Shilnikova K, Piao MJ, Kang KA, Madushan Fernando PDS, Lakmini Herath HMU, Cho SJ, Hyun JW
- KMID: 2526815
- Biomol Ther.
- 2022 Mar;30(2):137-144.
- doi: 10.4062/biomolther.2021.088
Radiation resistance represents an imperative obstacle in the treatment of patients with colorectal cancer, which remains difficult to overcome. Here, we explored the anti-proliferative and migration-inhibiting properties of the natural... -
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- Primary Cilium by Polyinosinic:Polycytidylic Acid Regulates the Regenerative Migration of Beas-2B Bronchial Epithelial Cells
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Gweon B, Jang TK, Thuy PX, Moon EY
- KMID: 2526819
- Biomol Ther.
- 2022 Mar;30(2):170-178.
- doi: 10.4062/biomolther.2022.009
The airway epithelium is equipped with the ability to resist respiratory disease development and airway damage, including the migration of airway epithelial cells and the activation of TLR3, which recognizes... -
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- The Effect of Galangin on the Regulation of Vascular Contractility via the Holoenzyme Reactivation Suppressing ROCK/CPI-17 rather than PKC/CPI-17
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Yoon HJ, Jung WP, Min YS, Jin F, Bang JS, Sohn UD, Je HD
- KMID: 2526816
- Biomol Ther.
- 2022 Mar;30(2):145-150.
- doi: 10.4062/biomolther.2021.087
In this study, we investigated the influence of galangin on vascular contractibility and to determine the mechanism underlying the relaxation. Isometric contractions of denuded aortic muscles were recorded and combined... -
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- Design, Synthesis, and Functional Evaluation of 1, 5-Disubstituted Tetrazoles as Monoamine Neurotransmitter Reuptake Inhibitors
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Paudel S, Wang S, Kim E, Kundu D, Min X, Shin CY, Kim KM
- KMID: 2526822
- Biomol Ther.
- 2022 Mar;30(2):191-202.
- doi: 10.4062/biomolther.2021.119
Tetrazoles were designed and synthesized as potential inhibitors of triple monoamine neurotransmitters (dopamine, norepinephrine, serotonin) reuptake based on the functional and docking simulation of compound 6 which were performed in... -
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- Gallic Acid Hindered Lung Cancer Progression by Inducing Cell Cycle Arrest and Apoptosis in A549 Lung Cancer Cells via PI3K/Akt Pathway
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Ko EB, Jang YG, Kim CW, Go RE, Lee HK, Choi KC
- KMID: 2526817
- Biomol Ther.
- 2022 Mar;30(2):151-161.
- doi: 10.4062/biomolther.2021.074
This study elucidates the anti-cancer potential of gallic acid (GA) as a promising therapeutic agent that exerts its effect by regulating the PI3K/Akt pathway. To prove our research rationale, we... -
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- A New Murine Liver Fibrosis Model Induced by Polyhexamethylene Guanidine-Phosphate
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Kim M, Hur S, Kim KH, Cho Y, Kim K, Kim HR, Nam KT, Lim KM
- KMID: 2526814
- Biomol Ther.
- 2022 Mar;30(2):126-136.
- doi: 10.4062/biomolther.2021.120
Liver fibrosis is part of the wound healing process to help the liver recover from the injuries caused by various liver-damaging insults. However, liver fibrosis often progresses to life-threatening cirrhosis... -
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- A Synthetic Analog of Resveratrol Inhibits the Proangiogenic Response of Liver Sinusoidal Cells during Hepatic Metastasis
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Olaso E, Benedicto A, Lopategi A, Cossio FP, Arteta B
- KMID: 2526818
- Biomol Ther.
- 2022 Mar;30(2):162-169.
- doi: 10.4062/biomolther.2021.062
We utilized Fas21, a resveratrol analog, to modulate the function of hepatic stellate cells (HSCs) and liver sinusoidal endothelial cells (LSECs) during the angiogenic phase of murine liver metastasis by... -
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- Loss of EMP2 Inhibits Melanogenesis of MNT1 Melanoma Cells via Regulation of TRP-2
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Enkhtaivan E, Kim HJ, Kim B, Byun HJ, Yu L, Nguyen TM, Nguyen TH, Do PA, Kim EJ, Kim KS, Huy HP, Rahman M, Jang JY, Rho SB, Lee H, Kang GJ, Park MK, Kim NH, Choi CI, Lee K, Han HK, Cho J, Lee AY, Lee CH
- KMID: 2526823
- Biomol Ther.
- 2022 Mar;30(2):203-211.
- doi: 10.4062/biomolther.2022.001
Melanogenesis is the production of melanin from tyrosine by a series of enzyme-catalyzed reactions, in which tyrosinase and DOPA oxidase play key roles. The melanin content in the skin determines... -
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