- Inhibition of Cytochrome P450 Enzymes by Drugs—Molecular Basis and Practical Applications
-
Guengerich FP
- KMID: 2524142
- Biomol Ther.
- 2022 Jan;30(1):1-18.
- doi: 10.4062/biomolther.2021.102
Drug-drug interactions are a major cause of hospitalization and deaths related to drug use. A large fraction of these is due to inhibition of enzymes involved in drug metabolism and... -
- CITED
-
- Close
- SHARE
-
- Close
- Botulinum Toxin A Ameliorates Neuroinflammation in the MPTP and 6-OHDA-Induced Parkinson’s Disease Models
-
Ham HJ, Yeo IJ, Jeon SH, Lim JH, Yoo SS, Son DJ, Jang SS, Lee H, Shin SJ, Han SB, Yun JS, Hong JT
- KMID: 2524151
- Biomol Ther.
- 2022 Jan;30(1):90-97.
- doi: 10.4062/biomolther.2021.077
Recently, increasing evidence suggests that neuroinflammation may be a critical factor in the development of Parkinson’s disease (PD) in addition to the ratio of acetylcholine/dopamine because dopaminergic neurons are particularly... -
- CITED
-
- Close
- SHARE
-
- Close
- Vinyl-Stilbene Inhibits Human Norovirus RNA Replication by Activating Heat-Shock Factor-1
-
Lee A, Sung J, Harmalkar DS, Kang H, Lee H, Lee K, Lee C
- KMID: 2524148
- Biomol Ther.
- 2022 Jan;30(1):64-71.
- doi: 10.4062/biomolther.2021.153
Norovirus (NV) is the most common cause of viral gastroenteritis, with the potential to develop into a fatal disease in those who are immuno-compromised, and effective vaccines and treatments are... -
- CITED
-
- Close
- SHARE
-
- Close
- Lithocholic Acid Activates Mas-Related G Protein-Coupled Receptors, Contributing to Itch in Mice
-
Song MH, Shim WS
- KMID: 2524145
- Biomol Ther.
- 2022 Jan;30(1):38-47.
- doi: 10.4062/biomolther.2021.059
The present study focused on lithocholic acid (LCA), a secondary bile acid that contributes to cholestatic pruritus. Although recent studies have found that LCA acts on MAS-related G protein-coupled receptor... -
- CITED
-
- Close
- SHARE
-
- Close
- Oleanolic Acid Provides Neuroprotection against Ischemic Stroke through the Inhibition of Microglial Activation and NLRP3 Inflammasome Activation
-
Sapkota A, Choi JW
- KMID: 2524147
- Biomol Ther.
- 2022 Jan;30(1):55-63.
- doi: 10.4062/biomolther.2021.154
Oleanolic acid (OA), a natural pentacyclic triterpenoid, has been reported to exert protective effects against several neurological diseases through its anti-oxidative and anti-inflammatory activities. The goal of the present study... -
- CITED
-
- Close
- SHARE
-
- Close
- Chronicles of EGFR Tyrosine Kinase Inhibitors: Targeting EGFR C797S Containing Triple Mutations
-
Duggirala KB, Lee Y, Lee K
- KMID: 2524143
- Biomol Ther.
- 2022 Jan;30(1):19-27.
- doi: 10.4062/biomolther.2021.047
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase widely expressed in many cancers such as non-small cell lung cancer (NSCLC), pancreatic cancer, breast cancer, and head and neck... -
- CITED
-
- Close
- SHARE
-
- Close
- Discovery of Cellular RhoA Functions by the Integrated Application of Gene Set Enrichment Analysis
-
Chun KH
- KMID: 2524152
- Biomol Ther.
- 2022 Jan;30(1):98-116.
- doi: 10.4062/biomolther.2021.075
The small GTPase RhoA has been studied extensively for its role in actin dynamics. In this study, multiple bioinformatics tools were applied cooperatively to the microarray dataset GSE64714 to explore... -
- CITED
-
- Close
- SHARE
-
- Close
- Melatonin Protects Chronic Kidney Disease Mesenchymal Stem/Stromal Cells against Accumulation of Methylglyoxal via Modulation of Hexokinase-2 Expression
-
Go G, Yoon YM, Yoon S, Lee G, Lim JH, Han SY, Lee SH
- KMID: 2524144
- Biomol Ther.
- 2022 Jan;30(1):28-37.
- doi: 10.4062/biomolther.2021.058
Treatment options for patients with chronic kidney disease (CKD) are currently limited; therefore, there has been significant interest in applying mesenchymal stem/stromal cell (MSC)-based therapy to treat CKD. However, MSCs... -
- CITED
-
- Close
- SHARE
-
- Close
- Enhancement of Radiosensitivity by DNA Hypomethylating Drugs through Apoptosis and Autophagy in Human Sarcoma Cells
-
Park MT, Kim SD, Han YK, Hyun JW, Lee HJ, Yi JM
- KMID: 2524150
- Biomol Ther.
- 2022 Jan;30(1):80-89.
- doi: 10.4062/biomolther.2021.174
The targeting of DNA methylation in cancer using DNA hypomethylating drugs has been well known to sensitize cancer cells to chemotherapy and immunotherapy by affecting multiple pathways. Herein, we investigated... -
- CITED
-
- Close
- SHARE
-
- Close
- Novel GPR43 Agonists Exert an Anti-Inflammatory Effect in a Colitis Model
-
Park BO, Kang JS, Paudel S, Park SG, Park BC, Han SB, Kwak YS, Kim JH, Kim S
- KMID: 2524146
- Biomol Ther.
- 2022 Jan;30(1):48-54.
- doi: 10.4062/biomolther.2021.078
GPR43 (also known as FFAR2), a metabolite-sensing G-protein-coupled receptor stimulated by short-chain fatty acid (SCFA) ligands is involved in innate immunity and metabolism. GPR43 couples with Gα i/o and Gα... -
- CITED
-
- Close
- SHARE
-
- Close
- Licochalcone H Induces Cell Cycle Arrest and Apoptosis in Human Skin Cancer Cells by Modulating JAK2/STAT3 Signaling
-
Park KH, Joo SH, Seo JH, Kim J, Yoon G, Jeon YJ, Lee MH, Chae JI, Kim WK, Shim JH
- KMID: 2524149
- Biomol Ther.
- 2022 Jan;30(1):72-79.
- doi: 10.4062/biomolther.2021.149
Licochalcone H (LCH) is a phenolic compound synthetically derived from licochalcone C (LCC) that exerts anticancer activity. In this study, we investigated the anticancer activity of LCH in human skin... -
- CITED
-
- Close
- SHARE
-
- Close
