- Conformational Dynamics of Sclerostin-LRP6 Complex Analyzed by HDX-MS
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Jeong Y, Kim J, Choi HJ, Chung KY
- KMID: 2519618
- Biomol Ther.
- 2021 Sep;29(5):527-535.
- doi: 10.4062/biomolther.2020.234
Sclerostin (SOST), a regulator of bone formation in osteocytes, inhibits the canonical Wnt signaling by interacting with low-density lipoprotein receptor-related protein 5/6 (LRP5/6) to prevent Wnt binding. Loss-of-function mutations of... -
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- Cyclooxygenase-2 Inhibitor Parecoxib Was Disclosed as a PPAR-γ Agonist by In Silico and In Vitro Assay
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Xiao B, Li Dd, Wang Y, Kim EL, Zhao N, Jin SW, Bai DH, Sun LD, Jung JH
- KMID: 2519617
- Biomol Ther.
- 2021 Sep;29(5):519-526.
- doi: 10.4062/biomolther.2021.008
In a search for effective PPAR-γ agonists, 110 clinical drugs were screened via molecular docking, and 9 drugs, including parecoxib, were selected for subsequent biological evaluation. Molecular docking of parecoxib... -
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- Anticancer Activity of Indeno[1,2-b]-Pyridinol Derivative as a New DNA Minor Groove Binding Catalytic Inhibitor of Topoisomerase IIα
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Jeon KH, Shrestha A, Jang HJ, Kim JA, Sheen N, Seo M, Lee ES, Kwon Y
- KMID: 2519622
- Biomol Ther.
- 2021 Sep;29(5):562-570.
- doi: 10.4062/biomolther.2020.231
Topoisomerase IIα has been a representative anti-cancer target for decades thanks to its functional necessity in highly proliferative cancer cells. As type of topoisomerase IIα targeting drugs, topoisomerase II poisons... -
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- Suppressive Effect of CYM50358 S1P4 Antagonist on Mast Cell Degranulation and Allergic Asthma in Mice
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Jeon WJ, Chung KW, Lee JH, Im DS
- KMID: 2519614
- Biomol Ther.
- 2021 Sep;29(5):492-497.
- doi: 10.4062/biomolther.2020.206
Levels of sphingosine 1-phosphate (S1P), an intercellular signaling molecule, reportedly increase in the bronchoalveolar lavage fluids of patients with asthma. Although the type 4 S1P receptor, S1P4 has been detected... -
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- Change in Cationic Amino Acid Transport System and Effect of Lysine Pretreatment on Inflammatory State in Amyotrophic Lateral Sclerosis Cell Model
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Latif S, Kang YS
- KMID: 2519615
- Biomol Ther.
- 2021 Sep;29(5):498-505.
- doi: 10.4062/biomolther.2021.037
Amyotrophic lateral sclerosis (ALS) is a lethal neurological disorder characterized by the deterioration of motor neurons. The aim of this study was to investigate alteration of cationic amino acid transporter... -
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- Specialized Proresolving Mediators for Therapeutic Interventions Targeting Metabolic and Inflammatory Disorders
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Han YH, Lee K, Saha A, Han J, Choi H, Noh M, Lee YH, Lee MO
- KMID: 2519611
- Biomol Ther.
- 2021 Sep;29(5):455-464.
- doi: 10.4062/biomolther.2021.094
Uncontrolled inflammation is considered the pathophysiological basis of many prevalent metabolic disorders, such as nonalcoholic fatty liver disease, diabetes, obesity, and neurodegenerative diseases. The inflammatory response is a self-limiting process... -
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- Bioactive Lipids and Their Derivatives in Biomedical Applications
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Park J, Choi J, Kim DD, Lee S, Lee B, Lee Y, Kim S, Kwon S, Noh M, Lee MO, Le QV, Oh YK
- KMID: 2519612
- Biomol Ther.
- 2021 Sep;29(5):465-482.
- doi: 10.4062/biomolther.2021.107
Lipids, which along with carbohydrates and proteins are among the most important nutrients for the living organism, have a variety of biological functions that can be applied widely in biomedicine.... -
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- Matrix Metalloproteinase-8 Inhibitor Ameliorates Inflammatory Responses and Behavioral Deficits in LRRK2 G2019S Parkinson’s Disease Model Mice
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Kim T, Jeon J, Park JS, Park Y, Kim J, Noh H, Kim HS, Seo H
- KMID: 2519613
- Biomol Ther.
- 2021 Sep;29(5):483-491.
- doi: 10.4062/biomolther.2020.181
Parkinson’s disease (PD) is a neurodegenerative disorder that involves the loss of dopaminergic neurons in the substantia nigra (SN). Matrix metalloproteinases-8 (MMP-8), neutrophil collagenase, is a functional player in the... -
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- Hyaluronic Acid Increases Anti-Inflammatory Efficacy of Rectal 5-Amino Salicylic Acid Administration in a Murine Colitis Model
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Jhundoo HD, Siefen T, Liang A, Schmidt C, Lokhnauth J, Moulari B, Béduneau A, Pellequer Y, Larsen CC, Lamprecht A
- KMID: 2519619
- Biomol Ther.
- 2021 Sep;29(5):536-544.
- doi: 10.4062/biomolther.2020.227
5-amino salicylic acid (5-ASA) is a standard therapy for the treatment of mild to moderate forms of inflammatory bowel diseases (IBD) whereas more severe forms involve the use of steroids... -
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- Novel Anti-Angiogenic and Anti-Tumour Activities of the N-Terminal Domain of NOEY2 via Binding to VEGFR-2 in Ovarian Cancer
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Rho SB, Lee KW, Lee SH, Byun HJ, Kim BR, Lee CH
- KMID: 2519616
- Biomol Ther.
- 2021 Sep;29(5):506-518.
- doi: 10.4062/biomolther.2021.121
The imprinted tumour suppressor NOEY2 is downregulated in various cancer types, including ovarian cancers. Recent data suggest that NOEY2 plays an essential role in regulating the cell cycle, angiogenesis and... -
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- ER71/ETV2 Promotes Hair Regeneration from Chemotherapeutic Drug-Induced Hair Loss by Enhancing Angiogenesis
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Lee TJ, Kang HK, Berry JC, Joo HG, Park C, Miller MJ, Choi K
- KMID: 2519620
- Biomol Ther.
- 2021 Sep;29(5):545-550.
- doi: 10.4062/biomolther.2021.022
Chemotherapy-induced alopecia and hair loss can be stressful in patients with cancer. The hair grows back, but sometimes the hair tends to stay thin. Therefore, understanding mechanisms regulating hair regeneration... -
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- Platelet-Derived Growth Factor Receptor-α Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo
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Lin CL, Tsai ML, Chen Yh, Liu WN, Lin CY, Hsu KW, Huang CY, Chang YJ, Wei PL, Chen SH, Huang LC, Lee CH
- KMID: 2519621
- Biomol Ther.
- 2021 Sep;29(5):551-561.
- doi: 10.4062/biomolther.2020.205
Thyroid cancer is the most common endocrine malignancy. Patients with well-differentiated thyroid cancers, such as papillary and follicular cancers, have a favorable prognosis. However, poorly differentiated thyroid cancers, such as... -
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