- Erratum to "Modulation of Human Cardiac Progenitors via Hypoxia-ERK Circuit Improves their Functional Bioactivities" [Biomol. Ther. 21 (2013) 196-203]
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Jung SY, Choi SH, Yoo SY, Baek SH, Kwon SM
- KMID: 2522258
- Biomol Ther.
- 2021 Nov;29(6):697-697.
- doi: 10.4062/biomolther.2021.697
no abstract available -
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- Lipid Metabolism, Disorders and Therapeutic Drugs – Review
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Natesan V, Kim SJ
- KMID: 2522247
- Biomol Ther.
- 2021 Nov;29(6):596-604.
- doi: 10.4062/biomolther.2021.122
Different lifestyles have an impact on useful metabolic functions, causing disorders. Different lipids are involved in the metabolic functions that play various vital roles in the body, such as structural... -
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- Neuronal Autophagy: Characteristic Features and Roles in Neuronal Pathophysiology
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Valencia M, Kim SR, Jang Y, Lee SH
- KMID: 2522248
- Biomol Ther.
- 2021 Nov;29(6):605-614.
- doi: 10.4062/biomolther.2021.012
Autophagy is an important degradative pathway that eliminates misfolded proteins and damaged organelles from cells. Autophagy is crucial for neuronal homeostasis and function. A lack of or deficiency in autophagy... -
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- Luteolin Promotes Apoptosis of Endometriotic Cells and Inhibits the Alternative Activation of Endometriosis-Associated Macrophages
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Woo JH, Jang DS, Choi JH
- KMID: 2522256
- Biomol Ther.
- 2021 Nov;29(6):678-684.
- doi: 10.4062/biomolther.2021.045
Luteolin, a flavonoid present in several fruits, vegetables, nuts, and herbs reportedly exhibits anti-cancer and anti-inflammatory properties. However, the effect of luteolin on endometriosis, a painful condition characterized by the... -
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- Eriodictyol Inhibits the Production and Gene Expression of MUC5AC Mucin via the IκBα-NF-κB p65 Signaling Pathway in Airway Epithelial Cells
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Yun C, Lee HJ, Lee CJ
- KMID: 2522251
- Biomol Ther.
- 2021 Nov;29(6):637-642.
- doi: 10.4062/biomolther.2021.091
In this study, we investigated whether eriodictyol exerts an effect on the production and gene expression of MUC5AC mucin in human pulmonary epithelial NCI-H292 cells. The cells were pretreated with... -
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- Systematic Review of Recent Lipidomics Approaches Toward Inflammatory Bowel Disease
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Lee EG, Yoon YC, Yoon J, Lee SJ, Oh YK, Kwon SW
- KMID: 2522246
- Biomol Ther.
- 2021 Nov;29(6):582-595.
- doi: 10.4062/biomolther.2021.125
Researchers have endeavored to identify the etiology of inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis. Though the pathogenesis of inflammatory bowel diseases remains unknown, dysregulation of the immune... -
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- AR-mTOR-SRF Axis Regulates HMMR Expression in Human Prostate Cancer Cells
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Sun Y, Li Z, Song K
- KMID: 2522255
- Biomol Ther.
- 2021 Nov;29(6):667-677.
- doi: 10.4062/biomolther.2021.040
The elevated expression of the hyaluronan-mediated motility receptor (HMMR) is known to be highly associated with tumor progression in prostate cancer, but the molecular mechanisms underlying the regulation of HMMR... -
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- Small Molecule Drug Candidates for Managing the Clinical Symptoms of COVID-19: a Narrative Review
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Yun C, Lee HJ, Lee CJ
- KMID: 2522245
- Biomol Ther.
- 2021 Nov;29(6):571-581.
- doi: 10.4062/biomolther.2021.134
Towards the end of 2019, an atypical acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China and subsequently named Coronavirus disease 2019... -
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- Hair Growth Promotion by δ-Opioid Receptor Activation
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Zheng M, Choi N, Balboni G, Xia Y, Sung JH
- KMID: 2522252
- Biomol Ther.
- 2021 Nov;29(6):643-649.
- doi: 10.4062/biomolther.2021.064
Literature has revealed that the delta opioid receptor (DOR) exhibited diverse pharmacological effects on neuron and skin. In the present study, we have investigated whether the activation of DOR has... -
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- Knockdown of LKB1 Sensitizes Endometrial Cancer Cells via AMPK Activation
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Rho SB, Byun HJ, Kim BR, Lee CH
- KMID: 2522253
- Biomol Ther.
- 2021 Nov;29(6):650-657.
- doi: 10.4062/biomolther.2021.131
Metformin is an anti-diabetic drug and has anticancer effects on various cancers. Several studies have suggested that metformin reduces cell proliferation and stimulates cell-cycle arrest and apoptosis. However, the definitive... -
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- Eupafolin Suppresses P/Q-Type Ca2+ Channels to Inhibit Ca2+ / Calmodulin-Dependent Protein Kinase II and Glutamate Release at Rat Cerebrocortical Nerve Terminals
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Chang A, Hung CF, Hsieh PW, Ko HH, Wang SJ
- KMID: 2522250
- Biomol Ther.
- 2021 Nov;29(6):630-636.
- doi: 10.4062/biomolther.2021.046
Eupafolin, a constituent of the aerial parts of Phyla nodiflora, has neuroprotective property. Because reducing the synaptic release of glutamate is crucial to achieving pharmacotherapeutic effects of neuroprotectants, we investigated... -
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- Podophyllotoxin Induces ROS-Mediated Apoptosis and Cell Cycle Arrest in Human Colorectal Cancer Cells via p38 MAPK Signaling
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Lee SO, Joo SH, Kwak AW, Lee MH, Seo JH, Cho SS, Yoon G, Chae JI, Shim JH
- KMID: 2522254
- Biomol Ther.
- 2021 Nov;29(6):658-666.
- doi: 10.4062/biomolther.2021.143
Podophyllotoxin (PT), a lignan compound from the roots and rhizomes of Podophyllum peltatum, has diverse pharmacological activities including anticancer effect in several types of cancer. The molecular mechanism of the... -
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- Neuroprotective Effect of Astersaponin I against Parkinson’s Disease through Autophagy Induction
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Zhang L, Park JY, Zhao D, Kwon HC, Yang HO
- KMID: 2522249
- Biomol Ther.
- 2021 Nov;29(6):615-629.
- doi: 10.4062/biomolther.2021.004
An active compound, triterpene saponin, astersaponin I (AKNS-2) was isolated from Aster koraiensis Nakai (AKNS) and the autophagy activation and neuroprotective effect was investigated on in vitro and in vivo... -
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- Suppression of Lipopolysaccharide-Induced Inflammatory and Oxidative Response by 5-Aminolevulinic Acid in RAW 264.7 Macrophages and Zebrafish Larvae
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Ji SY, Cha HJ, Neelaka Molagoda IM, Kim MY, Kim SY, Hwangbo H, Lee H, Kim GY, Kim DH, Hyun JW, Kim HS, Kim S, Jin CY, Choi YH
- KMID: 2522257
- Biomol Ther.
- 2021 Nov;29(6):685-696.
- doi: 10.4062/biomolther.2021.030
In this study, we investigated the inhibitory effect of 5-aminolevulinic acid (ALA), a heme precursor, on inflammatory and oxidative stress activated by lipopolysaccharide (LPS) in RAW 264.7 macrophages by estimating... -
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