- Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine
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Deyrup ST, Stagnitti NC, Perpetua MJ, Wong-Deyrup SW
- KMID: 2513479
- Biomol Ther.
- 2021 Mar;29(2):105-126.
- doi: 10.4062/biomolther.2020.229
Traditional Chinese medicine (TCM) was the primary source of medical treatment for the people inhabiting East Asia for thousands of years. These ancient practices have incorporated a wide variety of... -
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- Ibuprofen Increases the Hepatotoxicity of Ethanol through Potentiating Oxidative Stress
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Kim M, Lee EJ, Lim KM
- KMID: 2513488
- Biomol Ther.
- 2021 Mar;29(2):205-210.
- doi: 10.4062/biomolther.2020.108
Over 30 million prescriptions of NSAIDs (non-steroidal anti-inflammatory drugs) are issued every year. Considering that these drugs are available without a prescription as over the counter (OTC) drugs, their use... -
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- Endoplasmic Reticulum Stress-Mediated p62 Downregulation Inhibits Apoptosis via c-Jun Upregulation
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Yu W, Wang B, Zhou L, Xu G
- KMID: 2513487
- Biomol Ther.
- 2021 Mar;29(2):195-204.
- doi: 10.4062/biomolther.2020.089
Cereblon (CRBN), a substrate receptor of cullin 4-RING E3 ligase (CRL4) regulates the ubiquitination and degradation of c-Jun, mediating the lipopolysaccharide-induced cellular response. However, the upstream signaling pathway that regulates... -
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- Oleanolic Acid Protects the Skin from Particulate Matter-Induced Aging
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Kim YJ, Lee JE, Jang HS, Hong SY, Lee JB, Park SY, Hwang JS
- KMID: 2513490
- Biomol Ther.
- 2021 Mar;29(2):220-226.
- doi: 10.4062/biomolther.2020.106
The role of particulate matter (PM) in health problems including cardiovascular diseases (CVD) and pneumonia is becoming increasingly clear. Polycyclic aromatic hydrocarbons, major components of PM, bind to aryl hydrocarbon... -
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- Antineuroinflammatory Effects of 7,3’,4’-Trihydroxyisoflavone in Lipopolysaccharide-Stimulated BV2 Microglial Cells through MAPK and NF-κB Signaling Suppression
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Kim SK, Ko YH, Lee Y, Lee SY, Jang CG
- KMID: 2513480
- Biomol Ther.
- 2021 Mar;29(2):127-134.
- doi: 10.4062/biomolther.2020.093
Neuroinflammation—a common pathological feature of neurodegenerative disorders such as Alzheimer’s disease—is mediated by microglial activation. Thus, inhibiting microglial activation is vital for treating various neurological disorders. 7,3’,4’-Trihydroxyisoflavone (THIF)—a secondary metabolite... -
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- Effects of the Antidiabetic Drugs Evogliptin and Sitagliptin on the Immune Function of CD26/DPP4 in Th1 Cells
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Yoon H, Sung JH, Song MJ
- KMID: 2513483
- Biomol Ther.
- 2021 Mar;29(2):154-165.
- doi: 10.4062/biomolther.2020.150
This study aimed to investigate whether the antidiabetic drugs dipeptidyl peptidase 4 (DPP4) inhibitors such as evogliptin and sitagliptin affect the membrane DPP4 (mDPP4) enzymatic activity and immune function of... -
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- Late Passage Cultivation Induces Aged Astrocyte Phenotypes in Rat Primary Cultured Cells
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Bang M, Gonzales EL, Shin CY, Kwon KJ
- KMID: 2513482
- Biomol Ther.
- 2021 Mar;29(2):144-153.
- doi: 10.4062/biomolther.2020.175
Astrocytes play various important roles such as maintaining brain homeostasis, supporting neurons, and secreting inflammatory mediators to protect the brain cells. In aged subjects, astrocytes show diversely changed phenotypes and... -
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- KAT8/MOF-Mediated Anti-Cancer Mechanism of Gemcitabine in Human Bladder Cancer Cells
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Zhu H, Wang Y, Wei T, Zhao X, Li F, Li Y, Wang F, Cai Y, Jin J
- KMID: 2513486
- Biomol Ther.
- 2021 Mar;29(2):184-194.
- doi: 10.4062/biomolther.2020.111
Histone acetylation is a well-characterized epigenetic modification controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Imbalanced histone acetylation has been observed in many primary cancers. Therefore, efforts have been... -
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- Contributions of HO-1-Dependent MAPK to Regulating Intestinal Barrier Disruption
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Zhang Z, Zhang Q, Li F, Xin Y, Duan Z
- KMID: 2513485
- Biomol Ther.
- 2021 Mar;29(2):175-183.
- doi: 10.4062/biomolther.2020.131
The mitogen-activated protein kinase (MAPK) pathway controls intestinal epithelial barrier permeability by regulating tight junctions (TJs) and epithelial cells damage. Heme oxygenase-1 (HO-1) and carbon monoxide (CO) protect the intestinal... -
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- Gene Expression Profiling in the Striatum of Per2 KO Mice Exhibiting More Vulnerable Responses against Methamphetamine
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Kim M, Jeon SJ, Custodio RJ, Lee HJ, Sayson LV, Ortiz DMD, Cheong JH, Kim HJ
- KMID: 2513481
- Biomol Ther.
- 2021 Mar;29(2):135-143.
- doi: 10.4062/biomolther.2020.123
Drug addiction influences most communities directly or indirectly. Increasing studies have reported the relationship between circadian-related genes and drug addiction.Per2disrupted mice exhibited more vulnerable behavioral responses against some drugs including... -
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- Mechanisms of Resorcinol Antagonism of Benzo[a]pyrene-Induced Damage to Human Keratinocytes
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Lee SE, Kwon K, Oh SW, Park SJ, Yu E, Kim H, Yang S, Park JY, Chung WJ, Cho JY, Lee J
- KMID: 2513491
- Biomol Ther.
- 2021 Mar;29(2):227-233.
- doi: 10.4062/biomolther.2020.083
Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon and ubiquitous environmental toxin with known harmful effects to human health. Abnormal phenotypes of keratinocytes are closely associated with their exposure to B[a]P.... -
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- A Novel Anti-PD-L1 Antibody Exhibits Antitumor Effects on Multiple Myeloma in Murine Models via Antibody-Dependent Cellular Cytotoxicity
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Ahn JH, Lee BH, Kim SE, Kwon BE, Jeong H, Choi JR, Kim MJ, Park Y, Kim BS, Kim DH, Ko HJ
- KMID: 2513484
- Biomol Ther.
- 2021 Mar;29(2):166-174.
- doi: 10.4062/biomolther.2020.131
Multiple myeloma is a malignant cancer of plasma cells. Despite recent progress with immunomodulatory drugs and proteasome inhibitors, it remains an incurable disease that requires other strategies to overcome its... -
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- Systematic Target Screening Revealed That Tif302 Could Be an OffTarget of the Antifungal Terbinafine in Fission Yeast
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Lee S, Nam M, Lee AR, Lee J, Woo J, Kang NS, Balupuri A, Lee M, Kim SY, Ro H, Choi YW, Kim DU, Hoe KL
- KMID: 2513492
- Biomol Ther.
- 2021 Mar;29(2):234-247.
- doi: 10.4062/biomolther.2020.166
We used a heterozygous gene deletion library of fission yeasts comprising all essential and non-essential genes for a microarray screening of target genes of the antifungal terbinafine, which inhibits ergosterol... -
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- Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells
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Choi YK, Kang JI, Hyun JW, Koh YS, Kang JH, Hyun CG, Yoon KS, Lee KS, Lee CM, Kim TY, Yoo ES, Kang HK
- KMID: 2513489
- Biomol Ther.
- 2021 Mar;29(2):211-219.
- doi: 10.4062/biomolther.2020.169
Alopecia is a distressing condition caused by the dysregulation of anagen, catagen, and telogen in the hair cycle. Dermal papilla cells (DPCs) regulate the hair cycle and play important roles... -
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