- Methamphetamine-Induced Neuronal Damage: Neurotoxicity and Neuroinflammation
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Kim B, Yun J, Park B
- KMID: 2505682
- Biomol Ther.
- 2020 Sep;28(5):381-388.
- doi: 10.4062/biomolther.2020.044
Methamphetamine (METH) is a highly addictive psychostimulant and one of the most widely abused drugs worldwide. The continuous use of METH eventually leads to drug addiction and causes serious health... -
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- KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure
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Lee JH, Seo HW, Ryu JY, Lim CJ, Yi KY, Oh KS, Lee BH
- KMID: 2505694
- Biomol Ther.
- 2020 Sep;28(5):482-489.
- doi: 10.4062/biomolther.2020.129
G protein-coupled receptor kinase 5 (GRK5) has been considered as a potential target for the treatment of heart failure as it has been reported to be an important regulator of... -
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- Diclofenac Inhibits Phorbol Ester-Induced Gene Expression and Production of MUC5AC Mucin via Affecting Degradation of IkBα and Translocation of NF-kB p65 in NCI-H292 Cells
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Jin F, Li X, Lee HJ, Lee CJ
- KMID: 2505688
- Biomol Ther.
- 2020 Sep;28(5):431-436.
- doi: 10.4062/biomolther.2020.090
In this study, diclofenac, a non-steroidal anti-inflammatory drug, was investigated for its potential effect on the gene expression and production of airway MUC5AC mucin. The human respiratory epithelial NCI-H292 cells... -
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- Diallyl Biphenyl-Type Neolignans Have a Pharmacophore of PPARα/γ Dual Modulators
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Han Y, Liu J, Ahn S, An S, Ko H, Shin JC, Jin SH, Ki MW, Lee SH, Lee KH, Shin SS, Choi WJ, Noh M
- KMID: 2505684
- Biomol Ther.
- 2020 Sep;28(5):397-404.
- doi: 10.4062/biomolther.2019.180
Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adiponectin-secretion promoting compounds in... -
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- Epigenetically Upregulated T-Type Calcium Channels Contribute to Abnormal Proliferation of Embryonic Neural Progenitor Cells Exposed to Valproic Acid
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Kim JW, Oh HA, Kim SR, Oh MJ, Seung H, Lee SH, Shin SH
- KMID: 2505683
- Biomol Ther.
- 2020 Sep;28(5):389-396.
- doi: 10.4062/biomolther.2020.027
Valproic acid is a clinically used mood stabilizer and antiepileptic drug. Valproic acid has been suggested as a teratogen associated with the manifestation of neurodevelopmental disorders, such as fetal valproate... -
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- Synergistic Induction of Apoptosis by the Combination of an Axl Inhibitor and Auranofin in Human Breast Cancer Cells
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Ryu YS, Shin S, An HG, Kwon TU, Baek HS, Kwon YJ, Chun YJ
- KMID: 2505693
- Biomol Ther.
- 2020 Sep;28(5):473-481.
- doi: 10.4062/biomolther.2020.051
Axl receptor tyrosine kinase has been implicated in cancer progression, invasion, and metastasis in various cancer types. Axl overexpression has been observed in many cancers, and selective inhibitors of Axl,... -
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- Synovial Cell Migration is Associated with B Cell Activating Factor Expression Increased by TNFα or Decreased by KR33426
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Lee J, Yoon SS, Thuy PX, Moon EY
- KMID: 2505685
- Biomol Ther.
- 2020 Sep;28(5):405-413.
- doi: 10.4062/biomolther.2020.110
Fibroblast-like synoviocytes (FLS) play a crucial role in initiating rheumatoid arthritis. B-cell activating factor (BAFF) plays a role in FLS survival as well as in B cell maturation and maintenance.... -
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- Fangchinoline Has an Anti-Arthritic Effect in Two Animal Models and in IL-1β-Stimulated Human FLS Cells
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Villa T, Kim M, Oh S
- KMID: 2505686
- Biomol Ther.
- 2020 Sep;28(5):414-422.
- doi: 10.4062/biomolther.2020.113
Fangchinoline (FAN) is a bisbenzylisoquinoline alkaloid that is widely known for its anti-tumor properties. The goal of this study is to examine the effects of FAN on arthritis and the... -
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- Anti-Proliferative Activity of Nodosin, a Diterpenoid from Isodon serra, via Regulation of Wnt/β-Catenin Signaling Pathways in Human Colon Cancer Cells
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Bae ES, Kim YM, Kim DH, Byun WS, Park HJ, Chin YW, Lee SK
- KMID: 2505692
- Biomol Ther.
- 2020 Sep;28(5):465-472.
- doi: 10.4062/biomolther.2020.003
Colorectal cancer (CRC) is one of the most malignant type of cancers and its incidence is steadily increasing, due to life style factors that include western diet. Abnormal activation of... -
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- Telmisartan Inhibits TNFα-Induced Leukocyte Adhesion by Blocking ICAM-1 Expression in Astroglial Cells but Not in Endothelial Cells
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Jang C, Kim J, Kwon Y, Jo SA
- KMID: 2505687
- Biomol Ther.
- 2020 Sep;28(5):423-430.
- doi: 10.4062/biomolther.2020.119
Telmisartan is an angiotensin-II receptor blocker and acts as a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). Several studies have demonstrated that telmisartan ameliorates depression and memory dysfunction and... -
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- Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome
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Yang G, Lee SJ, Kang HC, Cho YY, Lee HS, Zouboulis CC, Han SH, Ma KH, Jang JK, Lee JY
- KMID: 2505689
- Biomol Ther.
- 2020 Sep;28(5):437-442.
- doi: 10.4062/biomolther.2020.004
Activation of the NLRP3 inflammasome is critical for host defense as well as the progression of inflammatory diseases through the production of the proinflammatory cytokine IL-1β, which is cleaved by... -
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- Dasatinib Inhibits Lyn and Fyn Src-Family Kinases in Mast Cells to Suppress Type I Hypersensitivity in Mice
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Lee D, Park YH, Lee JE, Kim HS, Min KY, Jo MG, Kim HS, Choi WS, Kim YM
- KMID: 2505691
- Biomol Ther.
- 2020 Sep;28(5):456-464.
- doi: 10.4062/biomolther.2020.013
Mast cells (MCs) are systemically distributed and secrete several allergic mediators such as histamine and leukotrienes to cause type I hypersensitivity. Dasatinib is a type of anti-cancer agent and it... -
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- Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway
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Hwangbo H, Kim SY, Lee H, Park SH, Hong SH, Park C, Kim GY, Leem SH, Hyun JW, Cheong J, Choi YH
- KMID: 2505690
- Biomol Ther.
- 2020 Sep;28(5):443-455.
- doi: 10.4062/biomolther.2020.122
The thioredoxin (Trx) system plays critical roles in regulating intracellular redox levels and defending organisms against oxidative stress. Recent studies indicated that Trx reductase (TrxR) was overexpressed in various types... -
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