- Dual Roles of Autophagy and Their Potential Drugs for Improving Cancer Therapeutics
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Shin DW
- KMID: 2508204
- Biomol Ther.
- 2020 Nov;28(6):503-511.
- doi: 10.4062/biomolther.2020.155
Autophagy is a major catabolic process that maintains cell metabolism by degrading damaged organelles and other dysfunctional proteins via the lysosome. Abnormal regulation of this process has been known to... -
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- Inhibition of LPA5 Activity Provides Long-Term Neuroprotection in Mice with Brain Ischemic Stroke
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Sapkota A, Park SJ, Choi JW
- KMID: 2508205
- Biomol Ther.
- 2020 Nov;28(6):512-518.
- doi: 10.4062/biomolther.2020.159
Stroke is a leading cause of long-term disability in ischemic survivors who are suffering from motor, cognitive, and memory impairment. Previously, we have reported suppressing LPA5 activity with its specific... -
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- MeBib Suppressed Methamphetamine Self-Administration Response via Inhibition of BDNF/ERK/CREB Signal Pathway in the Hippocampus
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Kim B, Jha S, Seo JH, Jeong CH, Lee S, Lee S, Seo YH, Park B
- KMID: 2508206
- Biomol Ther.
- 2020 Nov;28(6):519-526.
- doi: 10.4062/biomolther.2020.041
Methamphetamine (MA) is one of the most commonly abused drugs in the world by illegal drug users. Addiction to MA is a serious public health problem and effective therapies do... -
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- Topical Application of S1P2 Antagonist JTE-013 Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice
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Kang J, Lee JH, Im DS
- KMID: 2508208
- Biomol Ther.
- 2020 Nov;28(6):537-541.
- doi: 10.4062/biomolther.2020.036
Sphingosine-1-phosphate (S1P) and its receptors have been implicated in atopic dermatitis. S1P2 was found to function as a proallergic receptor, while its antagonist JTE-013 was found to suppress allergic asthma... -
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- Crotamiton, an Anti-Scabies Agent, Suppresses Histamine- and Chloroquine-Induced Itch Pathways in Sensory Neurons and Alleviates Scratching in Mice
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Choi DS, Ji Y, Jang Y, Lee WJ, Shim WS
- KMID: 2508212
- Biomol Ther.
- 2020 Nov;28(6):569-575.
- doi: 10.4062/biomolther.2020.063
Crotamiton is an anti-scabies drug, but it was recently found that crotamiton also suppresses non-scabietic itching in mice. However, the underlying mechanism is largely unclear. Therefore, aim of the study... -
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- Selonsertib Inhibits Liver Fibrosis via Downregulation of ASK1/ MAPK Pathway of Hepatic Stellate Cells
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Yoon YC, Fang Z, Lee JE, Park JH, Ryu JK, Jung KH, Hong SS
- KMID: 2508207
- Biomol Ther.
- 2020 Nov;28(6):527-536.
- doi: 10.4062/biomolther.2020.016
Liver fibrosis constitutes a significant health problem worldwide due to its rapidly increasing prevalence and the absence of specific and effective treatments. Growing evidence suggests that apoptosis-signal regulating kinase 1... -
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- Diosmetin and Its Glycoside, Diosmin, Improve Atopic DermatitisLike Lesions in 2,4-Dinitrochlorobenzene-Induced Murine Models
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Park Sa, Bong SK, Lee JW, Park NJ, Choi Y, Kim SM, Yang MH, Kim YK, Kim SN
- KMID: 2508209
- Biomol Ther.
- 2020 Nov;28(6):542-548.
- doi: 10.4062/biomolther.2020.135
Naturally derived diosmetin and its glycoside diosmin are known to be effective in treating inflammatory disease. This study was performed to determine whether diosmin and diosmetin have the effect of... -
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- Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells
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Kim MJ, Kang YJ, Sung B, Jang JY, Ahn YR, Oh HJ, Choi H, Choi I, Im E, Moon HR, Chung HY, Kim ND
- KMID: 2508211
- Biomol Ther.
- 2020 Nov;28(6):561-568.
- doi: 10.4062/biomolther.2020.153
We examined the anticancer effects of a novel sirtuin inhibitor, MHY2256, on HCT116 human colorectal cancer cells to investigate its underlying molecular mechanisms. MHY2256 significantly suppressed the activity of sirtuin... -
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- Activation of ATM/Akt/CREB/eNOS Signaling Axis by Aphidicolin Increases NO Production and Vessel Relaxation in Endothelial Cells and Rat Aortas
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Park JH, Cho DH, Hwang YJ, Lee JY, Lee HJ, Jo I
- KMID: 2508210
- Biomol Ther.
- 2020 Nov;28(6):549-560.
- doi: 10.4062/biomolther.2020.007
Although DNA damage responses (DDRs) are reported to be involved in nitric oxide (NO) production in response to genotoxic stresses, the precise mechanism of DDR-mediated NO production has not been... -
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- Sex-Biased Molecular Signature for Overall Survival of Liver Cancer Patients
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Kim SY, Song HK, Lee SK, Kim SG, Woo HG, Yang J, Noh HJ, Kim YS, Moon A
- KMID: 2508203
- Biomol Ther.
- 2020 Nov;28(6):491-502.
- doi: 10.4062/biomolther.2020.157
Sex/gender disparity has been shown in the incidence and prognosis of many types of diseases, probably due to differences in genes, physiological conditions such as hormones, and lifestyle between the... -
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