- Recent Trends in Cyclic Peptides as Therapeutic Agents and Biochemical Tools
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Choi JS, Joo SH
- KMID: 2507816
- Biomol Ther.
- 2020 Jan;28(1):18-24.
- doi: 10.4062/biomolther.2019.082
Notable progress has been made in the therapeutic and research applications of cyclic peptides since our previous review. New drugs based on cyclic peptides are entering the market, such as... -
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- Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors
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Lee SR, An EJ, Kim J, Bae YS
- KMID: 2507815
- Biomol Ther.
- 2020 Jan;28(1):25-33.
- doi: 10.4062/biomolther.2019.188
Several recent studies have reported that reactive oxygen species (ROS), superoxide anion and hydrogen peroxide (H2O2), play important roles in various cellular signaling networks. NADPH oxidase (Nox) isozymes have been... -
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- Impact of Sleep Disorder as a Risk Factor for Dementia in Men and Women
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Jee HJ, Shin W, Jung HJ, Kim B, Lee BK, Jung YS
- KMID: 2507810
- Biomol Ther.
- 2020 Jan;28(1):58-73.
- doi: 10.4062/biomolther.2019.192
Sleep is an essential physiological process, especially for proper brain function through the formation of new pathways and processing information and cognition. Therefore, when sleep is insufficient, this can result... -
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- Inhibitory Effect of Probenecid on Osteoclast Formation via JNK, ROS and COX-2
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Cheng MH, Kim SJ
- KMID: 2507801
- Biomol Ther.
- 2020 Jan;28(1):104-109.
- doi: 10.4062/biomolther.2019.047
Probenecid is a representative drug used in the treatment of gout. A recent study showed that probenecid effectively inhibits oxidative stress in neural cells. In the present study, we investigated... -
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- The Role of a Neurovascular Signaling Pathway Involving Hypoxia-Inducible Factor and Notch in the Function of the Central Nervous System
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Kim S, Lee M, Choi YK
- KMID: 2507811
- Biomol Ther.
- 2020 Jan;28(1):45-57.
- doi: 10.4062/biomolther.2019.119
In the neurovascular unit, the neuronal and vascular systems communicate with each other. O2 and nutrients, reaching endothelial cells (ECs) through the blood stream, spread into neighboring cells, such as... -
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- Lodoxamide Attenuates Hepatic Fibrosis in Mice: Involvement of GPR35
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Kim MJ, Park SJ, Nam SY, Im DS
- KMID: 2507803
- Biomol Ther.
- 2020 Jan;28(1):92-97.
- doi: 10.4062/biomolther.2018.227
A previous pharmacogenomic analysis identified cromolyn, an anti-allergic drug, as an effective anti-fibrotic agent that acts on hepatocytes and stellate cells. Furthermore, cromolyn was shown to be a G protein-coupled... -
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- Modulation of Immunosuppression by Oligonucleotide-Based Molecules and Small Molecules Targeting Myeloid-Derived Suppressor Cells
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Lim J, Lee A, Lee HG, Lim JS
- KMID: 2507817
- Biomol Ther.
- 2020 Jan;28(1):1-17.
- doi: 10.4062/biomolther.2019.069
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that exert suppressive function on the immune response. MDSCs expand in tumor-bearing hosts or in the tumor microenvironment and suppress T cell... -
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- Transforming Growth Factor β Receptor Type I Inhibitor, Galunisertib, Has No Beneficial Effects on Aneurysmal Pathological Changes in Marfan Mice
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- KMID: 2507804
- Biomol Ther.
- 2020 Jan;28(1):98-103.
- doi: 10.4062/biomolther.2019.042
Marfan syndrome (MFS), a connective tissue disorder caused by mutations in the fibrillin-1 (Fbn1) gene, has vascular manifestations including aortic aneurysm, dissection, and rupture. Its vascular pathogenesis is assumed to... -
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- Differentiation of Human Mesenchymal Stem Cells towards Neuronal Lineage: Clinical Trials in Nervous System Disorders
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Hernández R, Jiménez-Luna C, Perales-Adán J, Perazzoli G, Melguizo C, Prados J
- KMID: 2507813
- Biomol Ther.
- 2020 Jan;28(1):34-44.
- doi: 10.4062/biomolther.2019.065
Mesenchymal stem cells (MSCs) have been proposed as an alternative therapy to be applied into several pathologies of the nervous system. These cells can be obtained from adipose tissue, umbilical... -
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- β-Amyrin Ameliorates Alzheimer’s Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus
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Park HJ, Kwon H, Lee JH, Cho E, Lee YC, Moon M, Jun M, Kim DH, Jung JW
- KMID: 2507808
- Biomol Ther.
- 2020 Jan;28(1):74-82.
- doi: 10.4062/biomolther.2019.024
Alzheimer’s disease (AD) is a progressive and most frequently diagnosed neurodegenerative disorder. However, there is still no drug preventing the progress of this disorder. β-Amyrin, an ingredient of the surface... -
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- Longitudinal Study of Diabetic Differences between International Migrants and Natives among the Asian Population
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Piao H, Yun JM, Shin A, Cho B
- KMID: 2507800
- Biomol Ther.
- 2020 Jan;28(1):110-118.
- doi: 10.4062/biomolther.2019.163
Migration presents a substantial social and public health issue. However, it is unclear whether diabetes is worse among Asian migrants than natives of South Korea over time. This longitudinal study... -
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- Four Novel Synthetic Tryptamine Analogs Induce Head-Twitch Responses and Increase 5-HTR2a in the Prefrontal Cortex in Mice
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Abiero A, Ryu IS, Botanas CJ, Custodio RJP, Sayson LV, Kim M, Lee HJ, Kim HJ, Seo JW, Cho MC, Lee KW, Yoo SY, Jang CG, Lee YS, Cheong JH
- KMID: 2507806
- Biomol Ther.
- 2020 Jan;28(1):83-91.
- doi: 10.4062/biomolther.2019.049
Tryptamines are monoamine alkaloids with hallucinogenic properties and are widely abused worldwide. To hasten the regulations of novel substances and predict their abuse potential, we designed and synthesized four novel... -
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