- Formulation and Evaluation of Irinotecan Suppository for Rectal Administration
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Feng H, Zhu Y, Li D
- KMID: 2048335
- Biomol Ther.
- 2014 Jan;22(1):78-81.
Irinotecan suppository was prepared using the moulding method with a homogeneous blend. A sensitive and specific fluorescence method was developed and validated for the determination of irinotecan in plasma using... -
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- VEGF-VEGFR Signals in Health and Disease
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Shibuya M
- KMID: 2048324
- Biomol Ther.
- 2014 Jan;22(1):1-9.
Vascular endothelial growth factor (VEGF)-VEGF receptor (VEGFR) system has been shown to play central roles not only in physiological angiogenesis, but also in pathological angiogenesis in diseases such as cancer.... -
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- Identification of P-Glycoprotein and Transport Mechanism of Paclitaxel in Syncytiotrophoblast Cells
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Lee NY, Lee HE, Kang YS
- KMID: 2048333
- Biomol Ther.
- 2014 Jan;22(1):68-72.
When chemotherapy is administered during pregnancy, it is important to consider the fetus chemotherapy exposure, because it may lead to fetal consequences. Paclitaxel has become widely used in the metastatic... -
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- Enhanced In Vitro Skin Deposition Properties of Retinyl Palmitate through Its Stabilization by Pectin
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Suh DC, Kim Y, Kim H, Ro J, Cho SW, Yun G, Choi SU, Lee J
- KMID: 2048334
- Biomol Ther.
- 2014 Jan;22(1):73-77.
The purpose of this study was to examine the effect of stabilization of retinyl palmitate (RP) on its skin permeation and distribution profiles. Skin permeation and distribution study were performed... -
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- Inhibition of TNF-alpha-Mediated NF-kappaB Transcriptional Activity by Dammarane-Type Ginsenosides from Steamed Flower Buds of Panax ginseng in HepG2 and SK-Hep1 Cells
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Cho K, Song SB, Tung NH, Kim KE, Kim YH
- KMID: 2048331
- Biomol Ther.
- 2014 Jan;22(1):55-61.
Panax ginseng is a medicinal herb that is used worldwide. Its medicinal effects are primarily attributable to ginsenosides located in the root, leaf, seed, and flower. The flower buds of... -
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- Antiviral Activity of Hederasaponin B from Hedera helix against Enterovirus 71 Subgenotypes C3 and C4a
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Song J, Yeo SG, Hong EH, Lee BR, Kim JW, Kim J, Jeong H, Kwon Y, Kim H, Lee S, Park JH, Ko HJ
- KMID: 2048329
- Biomol Ther.
- 2014 Jan;22(1):41-46.
Enterovirus 71 (EV71) is the predominant cause of hand, foot and mouth disease (HFMD). The antiviral activity of hederasaponin B from Hedera helix against EV71 subgenotypes C3 and C4a was... -
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- Inhibition of Proinflammatory Cytokine Generation in Lung Inflammation by the Leaves of Perilla frutescens and Its Constituents
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Lim HJ, Woo KW, Lee KR, Lee SK, Kim HP
- KMID: 2048332
- Biomol Ther.
- 2014 Jan;22(1):62-67.
This study was designed to find some potential natural products and/or constituents inhibiting proinflammatory cytokine generation in lung inflammation, since cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6)... -
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- Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin
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Lee TH, Seo JO, Baek SH, Kim SY
- KMID: 2048328
- Biomol Ther.
- 2014 Jan;22(1):35-40.
Resveratrol is a polyphenolic compound found in various natural products such as grapes and berries and possesses anti-cancer, anti-hyperlipidemia, and anti-aging properties. Recently, it has been reported that resveratrol inhibits... -
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- Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels
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Li X, Lu Y, Jin Y, Son JK, Lee SH, Chang HW
- KMID: 2048327
- Biomol Ther.
- 2014 Jan;22(1):27-34.
Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, and to investigate its... -
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- Methyl p-Hydroxycinnamate Suppresses Lipopolysaccharide-Induced Inflammatory Responses through Akt Phosphorylation in RAW264.7 Cells
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Vo VA, Lee JW, Shin SY, Kwon JH, Lee HJ, Kim SS, Kwon YS, Chun W
- KMID: 2048325
- Biomol Ther.
- 2014 Jan;22(1):10-16.
Derivatives of caffeic acid have been reported to possess diverse pharmacological properties such as anti-inflammatory, anti-tumor, and neuroprotective effects. However, the biological activity of methyl p-hydroxycinnamate, an ester derivative of... -
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- Beneficial Antioxidative and Antiperoxidative Effect of Cinnamaldehyde Protect Streptozotocin-Induced Pancreatic beta-Cells Damage in Wistar Rats
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Subash-Babu P, Alshatwi A, Ignacimuthu S
- KMID: 2048330
- Biomol Ther.
- 2014 Jan;22(1):47-54.
The present study was aimed to evaluate the antioxidant defense system of cinnamaldehyde in normal, diabetic rats and its possible protection of pancreatic beta-cells against its gradual loss under diabetic... -
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- alpha-Asarone Ameliorates Memory Deficit in Lipopolysaccharide-Treated Mice via Suppression of Pro-Inflammatory Cytokines and Microglial Activation
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Shin JW, Cheong YJ, Koo YM, Kim S, Noh CK, Son YH, Kang C, Sohn NW
- KMID: 2048326
- Biomol Ther.
- 2014 Jan;22(1):17-26.
alpha-Asarone exhibits a number of pharmacological actions including neuroprotective, anti-oxidative, anticonvulsive, and cognitive enhancing action. The present study investigated the effects of alpha-asarone on pro-inflammatory cytokines mRNA, microglial activation, and... -
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