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Rheumatoid Hand Surgery in the Era of Biologic Therapy: A Rheumatologist-oriented Overview

Park JW, Hwang JS, Gong HS

Rheumatoid arthritis (RA) can cause significant hand and wrist damage and dysfunction. The aim of medical treatment is to eradicate inflammation and prevent damage to joints and soft tissues. Advances...
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Biologic therapies for the treatment of ankylosing spondylitis

Ahn SM, Kim YG

Ankylosing spondylitis (AS) is a chronic inflammatory disease predominantly affecting the axial skeleton. AS treatment aims to reduce pain and inflammation and maintain functional capacity. Nonsteroidal anti-inflammatory drugs are the...
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Biologic therapies for the treatment of systemic lupus erythematosus

Park SH

Systemic lupus erythematosus is a typical autoimmune disease with a complex etiology, including the interaction of genetic/epigenetic factors and environmental and hormonal factors with innate immune cells or B/T lymphocytes....
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Biologics for the Management of Inflammatory Bowel Disease: A Review in Tuberculosis-Endemic Countries

Banerjee R, Raja Ali RA, Wei SC, Adsul S

The advent of biologics and biologic therapy has transformed the management of inflammatory bowel disease (IBD) with enhanced early and adequate responses to treatment, fewer hospitalizations, a reduced need for...
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Biologic agents for asthma treatment

Kim SR, Lee JH

Most treatment strategies for asthma currently include inhaled corticosteroids, with the addition of long-acting beta-2-agonists or leukotriene modifiers, if necessary. However, some patients may not respond to conventional treatment. A...
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Fecal microbiota transplantation for refractory Crohn's disease

Bak SH, Choi HH, Lee J, Kim MH, Lee YH, Kim JS, Cho YS

Approximately one-third of patients with Crohn's disease do not respond to conventional treatments, and some experience significant adverse effects, such as serious infections and lymphoma, and many patients require surgery...
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Tumor Necrosis Factor Blockade Stimulates Circulating Osteoblastic Lineage Cells Activity while Reducing Circulating Osteoclasts

Lim MJ, Kwon SR, Jung KH, Park W

OBJECTIVE: This study examines the effects of tumor necrosis factor (TNF) blockade on markers of bone metabolism in peripheral blood from active rheumatoid arthritis (RA) patients. METHODS: Eighteen patients (16 women,...
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Biologic Agents in Rheumatic Diseases

Hong MJ, Yoo WH

  • KMID: 2263548
  • Korean J Med.
  • 2012 May;82(5):549-561.
During the past three decades the treatment in rheumatology was revolutionized by the introduction of disease-modifying anti-rheumatic drugs. Advances in our understanding of the pathogenesis of rheumatic diseases have led...
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Recent Advances in Mechanisms and Treatments of Airway Remodeling in Asthma: A Message from the Bench Side to the Clinic

Cho JY

Airway remodeling in asthma is a result of persistent inflammation and epithelial damage in response to repetitive injury. Recent studies have identified several important mediators associated with airway remodeling in...
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Anti-HER2/neu Peptide Producing Vector System for Biologic Therapy - Is It Possible to Mass-produce the Peptide?

Park BW, Kim KS, Heo MK, Lee KS, Kim EK, Kim KS

A humanized monoclonal antibody against HER2 has been using in a clinical setting and has been shown to possess therapeutic properties. A mimetic peptide against HER2 was also reported to...
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