- miRNA-125b Signaling Ameliorates Liver Injury Against Obstructive Jaundice-Induced Excessive Fibrosis in Experimental Rats
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Zhang X, Zhang F, Zhang C, Li J
- KMID: 2515250
- Yonsei Med J.
- 2021 May;62(5):453-460.
- doi: 10.3349/ymj.2021.62.5.453
Purpose: Multiple pathways are involved in inducing liver fibrosis, which can damage the integrity of liver. Among them, miR-125b has been found to exert an activating action on hepatic stellate... -
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- Increased Expression of S100B and RAGE in a Mouse Model of Bile Duct Ligation-induced Liver Fibrosis
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Park JW, Kim MJ, Kim SE, Kim HJ, Jeon YC, Shin HY, Park SJ, Jang MK, Kim DJ, Park CK, Choi EK
- KMID: 2514901
- J Korean Med Sci.
- 2021 Apr;36(14):e90.
- doi: 10.3346/jkms.2021.36.e90
Background: Liver fibrosis is defined as the accumulation of the extracellular matrix and scar formation. The receptor for advanced glycation end products (RAGE) has been demonstrated to participate in fibrogenesis.... -
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- Bile duct ligation of C57BL/6 mice as a model of hepatic encephalopathy
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Cho I, Koo BN, Kam EH, Lee SK, Oh H, Kim SY
- KMID: 2500450
- Anesth Pain Med.
- 2020 Jan;15(1):19-27.
- doi: 10.17085/apm.2020.15.1.19
Background: Bile duct ligation (BDL) has been used for experimental research on hepatic encephalopathy (HE) caused by chronic liver disease. However, little research has been done on a BDL model... -
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- Effect of Rifaximin on Hepatic Fibrosis in Bile Duct-ligated Rat Model
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Shin SK, Kwon OS, Lee JJ, Park YH, Choi CS, Jeong SH, Choi DJ, Kim YS, Kim JH
- KMID: 2398870
- Korean J Gastroenterol.
- 2017 Nov;70(5):239-246.
- doi: 10.4166/kjg.2017.70.5.239
BACKGROUND/AIMS: The translocation of bacteria and their lipopolysaccharides from the gut can promote fibrosis in cirrhotic patients. The aim of this study was to investigate the effects of rifaximin on... -
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- Decreased C-reactive protein induces abnormal vascular structure in a rat model of liver dysfunction induced by bile duct ligation
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Jun JH, Choi JH, Bae SH, Oh SH, Kim GJ
- KMID: 2373138
- Clin Mol Hepatol.
- 2016 Sep;22(3):372-381.
- doi: 10.3350/cmh.2016.0032
BACKGROUND/AIMS: Chronic liver disease leads to liver fibrosis, and although the liver does have a certain regenerative capacity, this disease is associated with dysfunction of the liver vessels. C-reactive protein... -
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- Rhus verniciflua Stokes attenuates cholestatic liver cirrhosis-induced interstitial fibrosis via Smad3 down-regulation and Smad7 up-regulation
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Gil MN, Choi DR, Yu KS, Jeong JH, Bak DH, Kim DK, Lee NS, Lee JH, Jeong YG, Na CS, Na DS, Ryu KH, Han SY
- KMID: 2353344
- Anat Cell Biol.
- 2016 Sep;49(3):189-198.
- doi: 10.5115/acb.2016.49.3.189
Cholestatic liver cirrhosis (CLC) eventually proceeds to end-stage liver failure by mediating overwhelming deposition of collagen, which is produced by activated interstitial myofibroblasts. Although the beneficial effects of Rhus verniciflua... -
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- Serum hyaluronic acid level: Correlation with quantitative measurement of hepatic fibrosis in a cirrhotic rat model
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Kim MY, Baik SK, Jang YO, Suk KT, Kim JW, Kim HS, Cho MY, Choi SJ, Um SH, Han KH
- KMID: 760780
- Korean J Hepatol.
- 2008 Jun;14(2):159-167.
- doi: 10.3350/kjhep.2008.14.2.159
BACKGROUNDS/AIMS: The serum level of hyaluronic acid (HA) has been suggested as a useful serologic marker for hepatic fibrosis. However, the relationship between serum HA levels and quantitative markers... -
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- Expression of Inducible Nitric Oxide Synthase (iNOS) in the Epithelial Cells of the Distended Bile Duct by the Bile Ductal Ligation
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Park SS, Jin GB, Park JW, Jang LC, Sung RH, Choi JW
- KMID: 2004555
- J Korean Surg Soc.
- 2003 May;64(5):365-371.
PURPOSE: Recent studies in an obstructive jaundice rat model showed that the bile duct epithelium is also very important in the bile duct dilatation besides the increased luminal pressure. This... -
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- Liver Fibrosis by Bile Duct Sclerosis with Ethanol: a New Experimental Model for Liver Fibrosis
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Song JH, Sung R, Jang LC, Park SM, Chae HB, Choi JW
- KMID: 2244320
- Korean J Hepatobiliary Pancreat Surg.
- 2002 Jun;6(1):42-47.
BACKGROUND/AIMS: Common bile duct ligation will induce cholestatic fibrosis or cirrhosis in the rat. However, the degree of histologic changes following ligation of the common bile duct appears to vary... -
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- Immunohistochemical Expression of Bcl-2 and Bax after Bile Duct Ligation in the Rat
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Yun KJ, Chae KM
- KMID: 1598621
- Korean J Gastroenterol.
- 2001 Apr;37(4):277-282.
BACKGROUND/AIMS: The cell homeostasis is regulated by a balance between apoptosis, proliferation and growth arrest. Bcl-2 and Bax belong to a family of cytoplasmic proteins that regulate apoptosis. The aim... -
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- Change of the Lymphocyte Stimulation Index and the Serum Immunoglobulin in Experimental Obstructive Jaundiced Rats
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Ahn CH, Kim DG
- KMID: 2209238
- J Korean Surg Soc.
- 2000 Jan;58(1):9-16.
BACKGROUND: The high incidence of operative complications in patients with jaundice is associated with an impaired immune system, an increased systemic and portal endotoxemia due to the decreased hepatic reticuloendothelial... -
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- Simple Auxiliary Liver Transplantation without Bile Duct Reconstruction in the Rat
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Yoo CH, Lee SS, Yoon MH
- KMID: 2198930
- J Korean Soc Transplant.
- 1999 Jun;13(1):39-44.
There has been numerous experimental liver transplantation models in the rodent : orthotopic versus hetrerotopic; whole liver versus partial liver; microvascular suture versus cuff method in technical aspects. Several simplified... -
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- Ultrastructural Changes of the Bile Canaliculi after Common Bile Duct Ligation
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Yoo KS, Lee SH, Park HK, Cho CH, Chae JM
- KMID: 1725063
- Korean J Pathol.
- 1996 Mar;30(3):175-183.
The purpose of this study was to investigate the morphologic changes of the bile canaliculi and its associated structures of the liver induced by common bile duct ligation(CBDL) in the... -
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- A Morphologic Study on the Bile Duct Changes Induced by Common Bile Duct Ligation in Rats
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Jeong JY, Kang DY, Noh SM
- KMID: 1724747
- Korean J Pathol.
- 1993 Dec;27(6):618-629.
In an attempt to elucidate the pathological changes following common bile duct ligation, the present study was undertaken in male Sprague-Dawley rats. Morphologic studies of the livers were performed at... -
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- The Effect of Common Bile Duct Ligation on Liver Morphology and Coper Metabolism in Rat
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Kim KS, Park C, Cho JW, Choi IJ, Lee YB
- KMID: 1724478
- Korean J Pathol.
- 1990 Dec;24(4):402-411.
To clarity the effect of biliary obliteration on copper metabolism of rat liver and on the hepatic morphology, 0.5% cuppuric sulfate was administered intraperitoneally for 42 days following ligation of... -
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