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miRNA-125b Signaling Ameliorates Liver Injury Against Obstructive Jaundice-Induced Excessive Fibrosis in Experimental Rats

Zhang X, Zhang F, Zhang C, Li J

Purpose: Multiple pathways are involved in inducing liver fibrosis, which can damage the integrity of liver. Among them, miR-125b has been found to exert an activating action on hepatic stellate...
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Increased Expression of S100B and RAGE in a Mouse Model of Bile Duct Ligation-induced Liver Fibrosis

Park JW, Kim MJ, Kim SE, Kim HJ, Jeon YC, Shin HY, Park SJ, Jang MK, Kim DJ, Park CK, Choi EK

Background: Liver fibrosis is defined as the accumulation of the extracellular matrix and scar formation. The receptor for advanced glycation end products (RAGE) has been demonstrated to participate in fibrogenesis....
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Bile duct ligation of C57BL/6 mice as a model of hepatic encephalopathy

Cho I, Koo BN, Kam EH, Lee SK, Oh H, Kim SY

Background: Bile duct ligation (BDL) has been used for experimental research on hepatic encephalopathy (HE) caused by chronic liver disease. However, little research has been done on a BDL model...
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Effect of Rifaximin on Hepatic Fibrosis in Bile Duct-ligated Rat Model

Shin SK, Kwon OS, Lee JJ, Park YH, Choi CS, Jeong SH, Choi DJ, Kim YS, Kim JH

BACKGROUND/AIMS: The translocation of bacteria and their lipopolysaccharides from the gut can promote fibrosis in cirrhotic patients. The aim of this study was to investigate the effects of rifaximin on...
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Decreased C-reactive protein induces abnormal vascular structure in a rat model of liver dysfunction induced by bile duct ligation

Jun JH, Choi JH, Bae SH, Oh SH, Kim GJ

BACKGROUND/AIMS: Chronic liver disease leads to liver fibrosis, and although the liver does have a certain regenerative capacity, this disease is associated with dysfunction of the liver vessels. C-reactive protein...
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Rhus verniciflua Stokes attenuates cholestatic liver cirrhosis-induced interstitial fibrosis via Smad3 down-regulation and Smad7 up-regulation

Gil MN, Choi DR, Yu KS, Jeong JH, Bak DH, Kim DK, Lee NS, Lee JH, Jeong YG, Na CS, Na DS, Ryu KH, Han SY

Cholestatic liver cirrhosis (CLC) eventually proceeds to end-stage liver failure by mediating overwhelming deposition of collagen, which is produced by activated interstitial myofibroblasts. Although the beneficial effects of Rhus verniciflua...
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Serum hyaluronic acid level: Correlation with quantitative measurement of hepatic fibrosis in a cirrhotic rat model

Kim MY, Baik SK, Jang YO, Suk KT, Kim JW, Kim HS, Cho MY, Choi SJ, Um SH, Han KH

BACKGROUNDS/AIMS: The serum level of hyaluronic acid (HA) has been suggested as a useful serologic marker for hepatic fibrosis. However, the relationship between serum HA levels and quantitative markers...
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Expression of Inducible Nitric Oxide Synthase (iNOS) in the Epithelial Cells of the Distended Bile Duct by the Bile Ductal Ligation

Park SS, Jin GB, Park JW, Jang LC, Sung RH, Choi JW

  • KMID: 2004555
  • J Korean Surg Soc.
  • 2003 May;64(5):365-371.
PURPOSE: Recent studies in an obstructive jaundice rat model showed that the bile duct epithelium is also very important in the bile duct dilatation besides the increased luminal pressure. This...
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Liver Fibrosis by Bile Duct Sclerosis with Ethanol: a New Experimental Model for Liver Fibrosis

Song JH, Sung R, Jang LC, Park SM, Chae HB, Choi JW

  • KMID: 2244320
  • Korean J Hepatobiliary Pancreat Surg.
  • 2002 Jun;6(1):42-47.
BACKGROUND/AIMS: Common bile duct ligation will induce cholestatic fibrosis or cirrhosis in the rat. However, the degree of histologic changes following ligation of the common bile duct appears to vary...
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Immunohistochemical Expression of Bcl-2 and Bax after Bile Duct Ligation in the Rat

Yun KJ, Chae KM

  • KMID: 1598621
  • Korean J Gastroenterol.
  • 2001 Apr;37(4):277-282.
BACKGROUND/AIMS: The cell homeostasis is regulated by a balance between apoptosis, proliferation and growth arrest. Bcl-2 and Bax belong to a family of cytoplasmic proteins that regulate apoptosis. The aim...
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Change of the Lymphocyte Stimulation Index and the Serum Immunoglobulin in Experimental Obstructive Jaundiced Rats

Ahn CH, Kim DG

  • KMID: 2209238
  • J Korean Surg Soc.
  • 2000 Jan;58(1):9-16.
BACKGROUND: The high incidence of operative complications in patients with jaundice is associated with an impaired immune system, an increased systemic and portal endotoxemia due to the decreased hepatic reticuloendothelial...
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Simple Auxiliary Liver Transplantation without Bile Duct Reconstruction in the Rat

Yoo CH, Lee SS, Yoon MH

  • KMID: 2198930
  • J Korean Soc Transplant.
  • 1999 Jun;13(1):39-44.
There has been numerous experimental liver transplantation models in the rodent : orthotopic versus hetrerotopic; whole liver versus partial liver; microvascular suture versus cuff method in technical aspects. Several simplified...
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Ultrastructural Changes of the Bile Canaliculi after Common Bile Duct Ligation

Yoo KS, Lee SH, Park HK, Cho CH, Chae JM

  • KMID: 1725063
  • Korean J Pathol.
  • 1996 Mar;30(3):175-183.
The purpose of this study was to investigate the morphologic changes of the bile canaliculi and its associated structures of the liver induced by common bile duct ligation(CBDL) in the...
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A Morphologic Study on the Bile Duct Changes Induced by Common Bile Duct Ligation in Rats

Jeong JY, Kang DY, Noh SM

  • KMID: 1724747
  • Korean J Pathol.
  • 1993 Dec;27(6):618-629.
In an attempt to elucidate the pathological changes following common bile duct ligation, the present study was undertaken in male Sprague-Dawley rats. Morphologic studies of the livers were performed at...
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The Effect of Common Bile Duct Ligation on Liver Morphology and Coper Metabolism in Rat

Kim KS, Park C, Cho JW, Choi IJ, Lee YB

  • KMID: 1724478
  • Korean J Pathol.
  • 1990 Dec;24(4):402-411.
To clarity the effect of biliary obliteration on copper metabolism of rat liver and on the hepatic morphology, 0.5% cuppuric sulfate was administered intraperitoneally for 42 days following ligation of...
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