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Antiepileptic Drug Therapy for Status Epilepticus

Kim D, Kim JM, Cho YW, Yang KI, Kim DW, Lee ST, No YJ, Seo JG, Byun JI, Kang KW, Kim KT, on behalf of the Drug Committee of Korean Epilepsy Society

Status epilepticus (SE) is one of the most serious neurologic emergencies. SE is a condition that encompasses a broad range of semiologic subtypes and heterogeneous etiologies. The treatment of SE...
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Assessment and Treatment of Alcohol Withdrawal Syndrome

Choi HY, Seo JS, Lee SK

Alcohol withdrawal syndrome (AWS) is the most common and well-known condition occurring after intentional or unintentionalcessation or decreasing heavy drinking. Approximately 5-10% of these people are suffering from serious medical...
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A Durable Minimal Intervention Strategy to Reduce Benzodiazepine Use in a Primary Care Population

Davidson S, Thomson C, Prescott G

Background: Benzodiazepines are commonly prescribed drugs with approximately 10% of adults having used them in the past year. These drugs are clearly addictive, yet many patients are prescribed these for...
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Midazolam use in pediatric dentistry: a review

Jain SA, Rathi N, Thosar N, Baliga S

Behaviour management and dental procedures performed in very young, pre-cooperative, highly anxious, or medically disabled children are challenging tasks. Various drugs and methods have, however, been introduced to facilitate treatment...
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Risk of Dementia in Long-Term Benzodiazepine Users: Evidence from a Meta-Analysis of Observational Studies

He Q, Chen X, Wu T, Li L, Fei X

BACKGROUND AND PURPOSE: There is conflicting evidence in the literature on the association between benzodiazepines (BDZs) and the risk of dementia. This meta-analysis aimed to determine the relationship between the...
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Benzodiazepine-Associated Carcinogenesis: Focus on Lorazepam-Associated Cancer Biomarker Changes in Overweight Individuals

Ku SC, Ho PS, Tseng YT, Yeh TC, Cheng SL, Liang CS

OBJECTIVE: Cellular, animal, and human epidemiological studies suggested that benzodiazepines increase the risk of cancer and cancer mortality. Obesity is also clearly linked to carcinogenesis. However, no human studies have...
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Assessment of Switching to Suvorexant versus the Use of Add-on Suvorexant in Combination with Benzodiazepine Receptor Agonists in Insomnia Patients: A Retrospective Study

Hatano M, Kamei H, Inagaki R, Matsuzaki , Hanya M, Yamada S, Iwata N

OBJECTIVE: Suvorexant is a novel hypnotic drug that does not interact with the conventional γ-aminobutyric acid (GABA)-A receptor. We investigated the method by which suvorexant was introduced in insomnia patients...
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The effect of triazolam premedication on anxiety, sedation, and amnesia in general anesthesia

Pyeon T, Chung S, Kim I, Lee S, Jeong S

BACKGROUND: Benzodiazepines have been used preoperatively as part of an anesthesia regimen to attenuate the anxiety of patients. In this study, we aimed to examine the effect of oral triazolam,...
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Risk Factors for Aspiration Pneumonia in Acute Benzodiazepine Overdose

Chung WS, Cha KM, Kim HM, Jeong WJ, So BH

  • KMID: 2328236
  • J Korean Soc Clin Toxicol.
  • 2016 Jun;14(1):26-32.
PURPOSE: Aspiration pneumonia is an important complication of drug intoxication with decreased mental status. The purpose of the study is to investigate the risk factors of aspiration pneumonia in the...
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Pharmacological Treatments for Tinnitus

Park SY

Pharmacotherapy has been constantly chosen by the clinician among the available treatment options for tinnitus. Medications that have been prescribed off-label to treat tinnitus can be grouped into several categories:...
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Flumazenil administration in suspected patients with acute hypnotics and sedatives poisoning: risk-benefit re-evaluation

Huh JH, Choi SC, Lim YG, Lampotang , Park EJ

PURPOSE: The use of flumazenil administration in the emergency department is still controversial because of concerns about adverse effects. The present study was conducted to re-evaluate the risk-benefit ratio associated...
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Clinical Analysis of Flumazenil Administration in the Single Emergency Department for Unconscious Patients, Suspected Benzodiazepine Overdose

Kim HJ, Kim YH, Lee JH, Hwang SY, Cho KW, Kang MJ, Lee DW, Lee KY, Lee NK

PURPOSE: Flumazenil is an effective benzodiazepine antagonist. However, serious adverse effects, including seizures, cardiac arrhythmias, and even death, have been reported in patients treated with flumazenil. These adverse effects are...
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A Case of Pulmonary Thromboembolism Complicating Acute Overdose of Benzodiazepines

Choi JY, Jeong J

  • KMID: 2333825
  • J Korean Soc Emerg Med.
  • 2014 Apr;25(2):199-201.
Acute pulmonary thromboembolism (PTE) is a major medical problem in many hospitalized patients with medical and surgical conditions, and venous thromboembolism is responsible for up to 15% of all in-hospital...
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Incidence of and Risk Ractors for Zolpidem-Induced Delirium

Kim YM, Lee S, Jung JY, Shin KH, Kim DH, Kim JH, Jee YK

  • KMID: 2142894
  • Korean J Med.
  • 2013 Jun;84(6):804-809.
BACKGROUND/AIMS: Zolpidem is a safe and effective drug for the treatment of insomnia. However, there are some reports of adverse effects, such as delirium, after administration of zolpidem. The aim...
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Small-Group Counseling in a Modified Tinnitus Retraining Therapy for Chronic Tinnitus

Park SN, Bae SC, Kim DK, Park YS, Yeo SW, Park SY

  • KMID: 2278428
  • Clin Exp Otorhinolaryngol.
  • 2013 Dec;6(4):214-218.
OBJECTIVES: The authors have treated chronic tinnitus patients using a combination of a simplified tinnitus retraining therapy (TRT) and medications, which we called modified TRT. In this clinical setting, we...
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Rhabdomyolysis due to hyponatremia in a patient taking benzodiazepines

Jeong JH, Cho JH, Yu CM, Suh SO, Ahn SJ, Jung JO, Kim YK

  • KMID: 2258728
  • Korean J Med.
  • 2008 Dec;75(6):718-722.
Hyponatremia is rarely reported to cause rhabdomyolysis and there has been only one case report on rhabdomyolysis due to hyponatremia, possibly complicated by benzodiazepines. We experienced a case of rhabdomyolysis...
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Midazolam Effects on Preoperative Anxiety and Hemodynamic Changes for Hypertensive and Normotensive Elderly Patients

Kim MW

BACKGROUND: Midazolam, a water soluble benzodiazepine, is a good sedative, hypnotic, anxiolytic, and anticonvulsant drug. During stressful condition such as an operation, sympathetic tone increases and cardiovascular variables are unstable....
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Effect of Supine or Jack-knife Position on the Arterial O2, CO2 Tension, Respiratory Rate and Oxygen Saturation Following Midazolam Sedation for Spinal Anesthesia

Lee IO, Kim JH, Park YC, Lee ES

BACKGROUND: Anorectal procedures are performed in the jack-knife position. The combined use of midazolam and spinal anesthesia is common in clinical practice. Despite the known potential for each to alter...
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The Clinical Study for Cardiovascular Responses and Awareness during Fentanyl - Diazepam - O2 Anesthesia for Open Heart Surgery

Jeon YJ, Kim KS, Kwon MI

Fentanyl-O2 anesthesia has gained wide popularity as an anesthetic technique for patients undergoing cardiac surgery because of its minimal cardiovascular effects and total amnesia for intraoperative events. But, some authors...
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