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Equine hyperimmune serum protects mice against Clostridium difficile spore challenge

Yan W, Shin KS, Wang SJ, Xiang H, Divers T, McDonough , Bowman J, Rowlands A, Akey B, Mohamed H, Chang YF

Clostridium (C.) difficile is a common cause of nosocomial diarrhea in horses. Vancomycin and metronidazole have been used as standard treatments but are only moderately effective, which highlights the need...
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The mucosal adjuvanticity of two nontoxic mutants of Escherichia coli heat-labile enterotoxin varies with immunization routes

Park EJ, Chang JH, Kim JS, Yum JS, Chung SI

  • KMID: 1109305
  • Exp Mol Med.
  • 2000 Jun;32(2):72-78.
Escherichia coli heat-labile enterotoxin (LT), which causes a characteristic diarrhea in humans and animals, is a strong mucosal immunogen and has powerful mucosal adjuvant activity towards coadministered unrelated antigens. Here...
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Development of two novel nontoxic mutants of Escherichia coli heat-labile enterotoxin

Park EJ, Chang JH, Kim JS, Chung SI, Yum JS

  • KMID: 1029939
  • Exp Mol Med.
  • 1999 Jun;31(2):101-107.
Escherichia coli heat-labile enterotoxin (LT) is composed of catalytic A and non-catalytic homo-pentameric B subunits and causes diarrheal disease in human and animals. In order to produce a nontoxic LT for vaccine...
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Development of a monoclonal antibody-based co-agglutination test to detect enterotoxigenic Escherichia coli isolated from diarrheic neonatal calves

Varshney B, Ponnanna N, Sarkar PA, Rehman P, Shah JH

Escherichia coli (E. coli) strains were collected from young diarrheic calves in farms and field. Strains that expressed the K99 (F5) antigen were identified by agglutination tests using reference antibodies...
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