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Emerging treatments for bacillus Calmette– Guérin-unresponsive non-muscle-invasive bladder cancer

Kim HS, Seo HK

Intravesical bacillus Calmette–Guérin (BCG) immunotherapy has been the gold standard adjuvant treatment for intermediateand high-risk non-muscle-invasive bladder cancer (NMIBC) after transurethral resection of bladder tumor (TURBT). BCG immunotherapy prevents disease...
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The Effects of Recombinant Bacillus Calmette-Guérin Resistant to Antimicrobial Peptides on Orthotopic Bladder Cancer Mouse Model

Hong SJ, Hwang GY, Kang SJ, Choi SY, Chi BH, Chang IH

Purpose: Although Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is the most widely used bladder cancer immunotherapy, innate immune responses involving antimicrobial peptides (AMPs) cause BCG failure. Here, we developed genetically modified...
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Rates and Risk Factors of Bacteriuria in Patients with Bladder Cancer Who Underwent Treatment with Bacillus Calmette-Guérin

Eun SJ, Kim MS, Jung SI, Choi HJ, Chung HS, Hwang EC, Kwon DD

Purpose: This study evaluated the rate and predictors of bacteriuria in patients who underwent transurethral resection of bladder tumor (TURBT) and Bacillus Calmette-Guérin (BCG) treatment. Materials and Methods: We prospectively evaluated...
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Performance of the Sysmex UF-1000i System in Screening for Significant Bacteriuria in Patients with Bladder Cancer Who Received Bacillus Calmette-Guérin Treatment

Kim TH, Jung SI, Kim MS, Choi HJ, Chung HS, Hwang EC, Kwon DD

Purpose: Diagnosing urinary tract infections by urine culture is time-consuming during a Bacillus Calmette-Guérin treatment. Because the urine culture results take time to collect, patients are treated presumptively, or Bacillus...
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Treatment Case of Asymptomatic Prostate Tuberculosis That Developed After Bacillus Calmette-Guerin Intravesical Therapy in a Patient With Nonmuscle Invasive Bladder Cancer

Kim JW, Lee SY, Kim YJ, Choi SH

Intravesical Bacillus Calmette-Guerin (BCG) therapy after transurethral resection of bladder tumor is considered the most effective treatment for prophylaxis against the recurrence of high risk nonmuscle invasive bladder cancer, and...
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Mycobacterium bovis Bacillus Calmette-Guerin (BCG) and BCG-based Vaccines Against Tuberculosis

Cha SB, Shin SJ

Tuberculosis (TB) is the second leading infectious cause of mortality worldwide with about two million deaths per year. The only licensed TB vaccine, Mycobacterium bovis bacillus Calmette-Guerin (BCG) shows limited...
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Management of BCG Failures in Non-Muscle-Invasive Bladder Cancer

Han KS, Hong SJ

  • KMID: 2314733
  • Korean J Urol.
  • 2009 Nov;50(11):1037-1047.
PURPOSE: Bacillus Calmette-Guerin (BCG) intravesical therapy is the standard treatment in high-risk patients with non-muscle-invasive bladder cancer, but a significant number of patients experience recurrence after BCG therapy. Although several...
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The Effect of Oral Prednisolone on Pseudo-tumor following Bacillus Calmette Guerin Intravesical Instillation

Park KK, Bang WJ, Seo JW, Kim YS, Lee SY, Ko WJ

Herein, the case of a patient where a pseudo-tumor on the bladder wall, with irritable bladder symptoms following a Bacillus Calmette Guerin (BCG) intravesical instillation, was treated by prednisolone administration...
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The Relationship Between the Serum Level of Cytokines (Interleukin-2, Interleukin-6, Interleukin-10, Interferon-gamma) and the Erythematous Induration of BCG Site in the Children with Kawasaki Disease

Kim SH, Huh J, Kang IS, Lee HJ

  • KMID: 2201199
  • J Korean Pediatr Cardiol Soc.
  • 2006 Jun;10(2):189-195.
PURPOSE: This study was aimed to investigate the clinical findings and the changes of serum levels of inflammatory cytokines according to the presence of erythematous induration at BCG (Bacillus Calmette-Guerin)...
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Effect of Intravesical High Dose Epirubicin versus Bacillus Calmette-Guerin Instillation on the Recurrence and Progression of Superficial Bladder Cancer: A Prospective, Multicenter Study

Hong SJ, Choi HY, Ahn HJ, Kim CS, Yang WJ

  • KMID: 2293983
  • Korean J Urol.
  • 2005 Jul;46(7):677-682.
PURPOSE: To investigate the effects of intravesical high dose epirubicin instillation, the effect of epirubicin was compared with that of Bacillus Calmette-Guerin (BCG) instillation on the recurrence and progression of...
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Ultrasonographic Features of BCG Lymphadenitis

Kim DY, Lee SW, Hwang JY

PURPOSE: To evaluate the ultrasonographic findings of BCG lymphadenitis complicated by BCG vaccination in children MATERIALS AND METHODS: Ultrasonography was performed for 22 cases of BCG lymphadenitis in 21 patients who...
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Changes of Nitric Oxide and Cell Proliferation after Bacillus Calmette-Guerin and Nitric Oxide Synthase Inhibitor Treatment on Murine Bladder Tumor-2 Cell Line

Ryu SB, Oh BR, Kang TW, Oh SH, Nah HS, Lee HC

  • KMID: 2293754
  • Korean J Urol.
  • 2003 Feb;44(2):155-159.
PURPOSE: We hypothesize that the cytolytic activity of Bacillus Calmette-Guerin (BCG) may act through nitric oxide (NO) production, and that cell death is correlated with apoptosis, changes of NO and...
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Change of Nitric Oxide Synthase Gene and Protein Expressions after Bacillus Calmette-Guerin Instillation into Rat Bladder

Oh BR, Kim HJ, Ahn KY, Kwon DD, Ryu SB, Park YI

  • KMID: 2292334
  • Korean J Urol.
  • 2001 Apr;42(4):413-419.
PURPOSE: We hypothesize that bacillus Calmette-Guerin (BCG) may act through the regulation of various isoforms of nitric oxide synthase (NOS) [inducible (iNOS), endothelial (eNOS), and neuronal (nNOS)] genes and proteins...
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Various Ultrasonographic Manifestations of Bacille Calmette-Guerin (BCG) Lymphadenitis in Infants after BCG Vaccination

Yoon CS, Kim MJ, Lee KH, Kwon WC, Cho N, Lee SI, Park KY, Kim DJ

  • KMID: 1558100
  • J Korean Soc Med Ultrasound.
  • 1999 Dec;18(4):319-323.
PURPOSE: To evaluate the various ultrasonographic manifestations of BCG lymphadenitis complicated by BCG vaccination in infants MATERIALS and METHODS:Among a total of 59 patients of BCG lymphadenitis, we retrospectively evaluated the...
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Recurrence and Progression of Stage T1 Bladder Tumor after Intravesical Bacillus Calmette-Guerin(BCG) Therapy

Ha HS, Park CH, Kim CI

  • KMID: 2290122
  • Korean J Urol.
  • 1999 Oct;40(10):1279-1282.
PURPOSE: The management of patients with superficially invasive, stage T1N0M0 bladder cancer remains controversial. While some physicians advocated early cystectomy, others believe that with initial TURB and effective intravesical BCG,...
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The Effect of Lubricant on the Viabillty of Bacillus Calmette-Guerin

Heo MW, Song HY, Lee NK

  • KMID: 1881259
  • Korean J Urol.
  • 1998 Jul;39(7):651-655.
PURPOSE: Intravesical instillation of bacillus Calmette-Guerin(BCG) is an established and effective therapy for the superficial bladder carcinoma. The viability of BCG is crucial for the induction of a local immune...
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Change of Cellular Immunity and T Cell Subset of Mouse Immunocytes Activated by Fractionated Bacillus Calmette-Guerin

Lee E, Jeong H, Yoon SJ, Lee HW, Min KJ, Choi YK, Lee C

  • KMID: 1884659
  • Korean J Urol.
  • 1998 May;39(5):423-430.
PURPOSE: To develope the bacillus Calmette-Guerin(BCG) antitumor component therapy which could reduce the adverse effect of intravesical BCG therapy, we investigated the effect of the fractions of BCG on...
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The Effects of Intravesical BCG Instillation on Bladder Cancer Induced by N-butyl-N-(4-hydroxybutyl) Nitrosamine

Song HC, Kim SW, Rim JS

  • KMID: 2290227
  • Korean J Urol.
  • 1998 Feb;39(2):110-115.
PURPOSE: We investigate the effects of intravesical BCG therapy on the occurance of superficial bladder cancer induced by N-butyl-N-(4-hydroxybutyl) nitrosamine(BBN) in Fisher 344 rats in vivo. We also examine...
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Management of BCG lymphadenitis

Oh JT, Kim IG, Han SJ, Hwang EH

Bacillus Calmette-Guerin(BCG) lymphadenitis is a complication of post-BCG vaccination and its treatment is still controversial. Eighty patients who had been operated for BCG lymphadenitis from 1987 to 1996 were reviewed....
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Detection or Interleukin 2 In The Urine of Patients with Superficial Bladder Tumors after Intravesical BCG Therapy

Kim EK, Lee NK, Park YH

  • KMID: 2060684
  • Korean J Urol.
  • 1996 Nov;37(11):1227-1233.
Intravesical Bacillus Calmette-Guerin (BCG) therapy is an effective immunotherapy used for the treatment and prophylaxis of superficial bladder cancer. The mechanism through which BCG exerts its antitumor activity is not...
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