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Classical natural ovine scrapie prions detected in practical volumes of blood by lamb and transgenic mouse bioassays

Dassanayake RP, Truscott T, Zhuang D, Schneider , Madsen-Bouterse SA, Young AJ, Stanton JB, Davis WC, O'Rourke K

Scrapie is diagnosed antemortem in sheep by detecting misfolded isoforms of prion protein (PrP(Sc)) in lymphoid follicles of the rectal mucosa and nictitating membranes. Assay sensitivity is limited if (a)...
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EBV-driven B-cell lymphoproliferative disorders: from biology, classification and differential diagnosis to clinical management

Ok CY, Li L, Young KH

Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, affecting >90% of the adult population. EBV targets B-lymphocytes and achieves latent infection in a circular episomal form. Different latency patterns are recognized...
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