- DNA Methylation Changes Following 5-azacitidine Treatment in Patients with Myelodysplastic Syndrome
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Tran HT, Kim HN, Lee IK, Kim YK, Ahn JS, Yang DH, Lee JJ, Kim HJ
- KMID: 1782108
- J Korean Med Sci.
- 2011 Feb;26(2):207-213.
- doi: 10.3346/jkms.2011.26.2.207
DNA methyltransferase inhibitor, 5-azacitidine (AC) is effective in myelodysplastic syndromes (MDS) and can induce re-expression in cancer. We analyzed the methylation of 25 tumor suppressor genes in AC-treated MDS. Hypermethylation... -
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- 5-azacytidine induces cardiac differentiation of P19 embryonic stem cells
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Choi SC, Yoon JH, Shim WJ, Ro YM, Lim DS
- KMID: 1103318
- Exp Mol Med.
- 2004 Dec;36(6):515-523.
The P19 embryonal carcinoma cell line is a useful model cells for studies on cardiac differentiation. However, its low efficacy of differentiation hampers its usefulness. We investigated the effect of... -
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