- Proliferation of Toxoplasma gondii Suppresses Host Cell Autophagy
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Lee YJ, Song HO, Lee YH, Ryu JS, Ahn MH
- KMID: 1715701
- Korean J Parasitol.
- 2013 Jun;51(3):279-287.
- doi: 10.3347/kjp.2013.51.3.279
Autophagy is a process of cytoplasmic degradation of endogenous proteins and organelles. Although its primary role is protective, it can also contribute to cell death. Recently, autophagy was found to... -
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- Expression of Heat Shock Protein 70 Modulates the Chemoresponsiveness of Pancreatic Cancer
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Hyun JJ, Lee HS, Keum B, Seo YS, Jeen YT, Chun HJ, Um SH, Kim CD
- KMID: 1712336
- Gut Liver.
- 2013 Nov;7(6):739-746.
BACKGROUND/AIMS: Heat shock protein (HSP) 70 is constitutively overexpressed in pancreatic cancer cells (PCCs) and appears to confer protection against chemotherapeutics. We investigated whether modulating HSP 70 increases chemoresponsiveness to... -
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- Autophagic failure promotes the exocytosis and intercellular transfer of alpha-synuclein
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Lee HJ, Cho ED, Lee KW, Kim JH, Cho SG, Lee SJ
- KMID: 2154241
- Exp Mol Med.
- 2013 May;45(5):e22.
The accumulation of abnormal protein aggregates is a major characteristic of many neurodegenerative disorders, including Parkinson's disease (PD). The intracytoplasmic deposition of alpha-synuclein aggregates and Lewy bodies, often found in... -
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- Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
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Ciechanover A, Kwon YT
- KMID: 2155412
- Exp Mol Med.
- 2015 Mar;47(3):e147.
- doi: 10.1038/emm.2014.117
Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the... -
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