- Why is autophagy important in human diseases?
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Jing K, Lim K
- KMID: 1120124
- Exp Mol Med.
- 2012 Feb;44(2):69-72.
- doi: 10.3858/emm.2012.44.2.028
The process of macroautophagy (referred to hereafter as autophagy), is generally characterized by the prominent formation of autophagic vesicles in the cytoplasm. In the past decades, studies of autophagy have... -
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- Autophagy and bacterial infectious diseases
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Yuk JM, Yoshimori , Jo EK
- KMID: 1120128
- Exp Mol Med.
- 2012 Feb;44(2):99-108.
- doi: 10.3858/emm.2012.44.2.032
Autophagy is a housekeeping process that maintains cellular homeostasis through recycling of nutrients and degradation of damaged or aged cytoplasmic constituents. Over the past several years, accumulating evidence has suggested... -
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- Autophagy and cancer
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Choi KS
- KMID: 1120129
- Exp Mol Med.
- 2012 Feb;44(2):109-120.
- doi: 10.3858/emm.2012.44.2.033
Basal autophagy plays a critical role in maintaining cellular homeostasis and genomic integrity by degrading aged or malfunctioning organelles and damaged or misfolded proteins. However, autophagy also plays a complicated... -
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- Neuronal autophagy and neurodegenerative diseases
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Son JH, Shim JH, Kim KH, Ha JY, Han JY
- KMID: 1120127
- Exp Mol Med.
- 2012 Feb;44(2):89-98.
- doi: 10.3858/emm.2012.44.2.031
Autophagy is a dynamic cellular pathway involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. The integrity of postmitotic neurons is heavily dependent on high basal... -
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