- Endothelial Dysfunction: Clinical Implications in Cardiovascular Disease and Therapeutic Approaches
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Park KH, Park WJ
- KMID: 2344144
- J Korean Med Sci.
- 2015 Sep;30(9):1213-1225.
- doi: 10.3346/jkms.2015.30.9.1213
Atherosclerosis is a chronic progressive vascular disease. It starts early in life, has a long asymptomatic phase, and a progression accelerated by various cardiovascular risk factors. The endothelium is an... -
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- Pycnogenol attenuates atherosclerosis by regulating lipid metabolism through the TLR4-NF-kappaB pathway
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Luo H, Wang J, Qiao C, Ma N, Liu D, Zhang W
- KMID: 2160622
- Exp Mol Med.
- 2015 Oct;47(10):e191.
- doi: 10.1038/emm.2015.74
Atherosclerosis is a leading cause of death worldwide and is characterized by lipid-laden foam cell formation. Recently, pycnogenol (PYC) has drawn much attention because of its prominent effect on cardiovascular... -
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- Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation
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Jung IH, Lee YH, Yoo JY, Jeong SJ, Sonn SK, Park JG, Ryu KH, Lee BY, Han HY, Lee SY, Kim DY, Lee H, Oh GT
- KMID: 1383792
- Exp Mol Med.
- 2012 May;44(5):311-318.
In this study, the synergistic effect of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone (cilostazol) and Ginkgo biloba extract (GbE) was examined in apolipoprotein E (ApoE) null mice. Co-treatment with GbE and cilostazol synergistically decreased... -
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- 5-(4-Hydroxy-2,3,5-trimethylbenzylidene) thiazolidine-2,4-dione attenuates atherosclerosis possibly by reducing monocyte recruitment to the lesion
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Choi JH, Park JG, Jeon HJ, Kim MS, Lee MR, Lee MN, Sonn S, Kim JH, Lee MH, Choi MS, Park YB, Kwon OS, Jeong TS, Lee WS, Shim HB, Shin DH, Oh GT
- KMID: 1022122
- Exp Mol Med.
- 2011 Aug;43(8):471-478.
- doi: 10.3858/emm.2011.43.8.053
A variety of benzylidenethiazole analogs have been demonstrated to inhibit 5-lipoxygenase (5-LOX). Here we report the anti-atherogenic potential of 5-(4-hydroxy-2,3,5-trimethylbenzylidene) thiazolidin-2,4-dione (HMB-TZD), a benzylidenethiazole analog, and its potential mechanism of... -
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- A reconstituted HDL containing V156K or R173C apoA-I exhibited anti-inflammatory activity in apo-E deficient mice and showed resistance to myeloperoxidase-mediated oxidation
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Cho KH, Kim JR
- KMID: 756234
- Exp Mol Med.
- 2009 Jun;41(6):417-428.
- doi: 10.3858/emm.2009.41.6.047
It has been hypothesized that blood infusion of reconstituted HDL (rHDL) is a possible therapeutic strategy for the treatment of coronary artery disese. To compare short-term anti-inflammatory activity of wildtype... -
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