- Induction of Bis, a Bcl-2-binding protein, in reactive astrocytes of the rat hippocampus following kainic acid-induced seizure
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Lee MY, Kim SY, Choi JS, Choi YS, Jeon MH, Lee JH, Kim IK, Lee JH
- KMID: 1081467
- Exp Mol Med.
- 2002 May;34(2):167-171.
The expression of Bis (also called Bag-3), a Bcl-2-binding protein, was investigated in the rat kainic acid (KA) model of temporal lobe epilepsy. Western blot analysis showed a significant increase... -
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- Reactive Astrocytes Expressing Intense Estrogen Receptor-alpha Immunoreactivities Have Much Elongated Cytoplasmic Processes: An Autopsy Case of Human Cerebellar Tissue with Multiple Genitourinary and Gastrointestinal Anomalies
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Kim EJ, Oh CS, Kim J, Kim WH, Chung YH, Shin DH
- KMID: 1713309
- J Korean Med Sci.
- 2007 Oct;22(5):936-941.
- doi: 10.3346/jkms.2007.22.5.936
We performed an immunohistochemical study on the estrogen receptor alpha (ER-alpha) distribution in the cerebellum of a human neonate with multiple congenital anomalies, that had been acquired during autopsy. Although... -
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- Phosphatidylinositol 4-phosphate 5-kinase alpha is induced in ganglioside-stimulated brain astrocytes and contributes to inflammatory responses
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Lee SY, Kim B, Yoon S, Kim YJ, Liu T, Woo JH, Chwae YJ, Joe EH, Jou I
- KMID: 983958
- Exp Mol Med.
- 2010 Sep;42(9):662-673.
- doi: 10.3858/emm.2010.42.9.066
In brain tissue, astrocytes play defensive roles in central nervous system integrity by mediating immune responses against pathological conditions. Type I phosphatidylinositol 4-phosphate 5-kinase alpha (PIP5Kalpha) that is responsible for... -
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- Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes
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Yun JH, Park SJ, Jo A, Kang JL, Jou I, Park JS, Choi YH
- KMID: 1058703
- Exp Mol Med.
- 2011 Dec;43(12):660-668.
- doi: 10.3858/emm.2011.43.12.075
Recent evidence supports a neuroprotective role of Src homology 2-containing protein tyrosine phosphatase 2 (SHP-2) against ischemic brain injury. However, the molecular mechanisms of SHP-2 activation and those governing how... -
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- Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer's disease
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Choi BR, Cho WH, Kim J, Lee HJ, Chung C, Jeon WK, Han JS
- KMID: 2155340
- Exp Mol Med.
- 2014 Feb;46(2):e75.
- doi: 10.1038/emm.2013.147
The receptor for advanced glycation end products (RAGE) has been reported to have a pivotal role in the pathogenesis of Alzheimer's disease (AD). This study investigated RAGE levels in the... -
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- Hydrogen Peroxide Upregulates TNF-Related Apoptosis-Inducing Ligand (TRAIL) Expression in Human Astroglial Cells, and Augments Apoptosis of T Cells
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Kwon D, Choi IH
- KMID: 1779506
- Yonsei Med J.
- 2006 Aug;47(4):551-557.
- doi: 10.3349/ymj.2006.47.4.551
The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing... -
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