- Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction
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Herrero A, Benedicto A, Romayor I, Olaso E, Arteta B
- KMID: 2515283
- Biomol Ther.
- 2021 May;29(3):342-351.
- doi: 10.4062/biomolther.2020.160
Liver colonization is initiated through the interplay between tumor cells and adhesion molecules present in liver sinusoidal endothelial cells (LSECs). This crosstalk stimulates tumor COX-2 upregulation and PGE 2 secretion.... -
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- A Synthetic Analog of Resveratrol Inhibits the Proangiogenic Response of Liver Sinusoidal Cells during Hepatic Metastasis
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Olaso E, Benedicto A, Lopategi A, Cossio FP, Arteta B
- KMID: 2526818
- Biomol Ther.
- 2022 Mar;30(2):162-169.
- doi: 10.4062/biomolther.2021.062
We utilized Fas21, a resveratrol analog, to modulate the function of hepatic stellate cells (HSCs) and liver sinusoidal endothelial cells (LSECs) during the angiogenic phase of murine liver metastasis by... -
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