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Tissue Catecholamines in Hypercholesteremic Rabbits

Lee WC, Yoo CS

Hypercholesteremia was induced by cholesterol feeding of rabbits for 10 weeks. Gross examination of aorta of these animals showed an evidence of atheromatous lesions. The endogenous catecholamines in heart, adrenal...
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Expression of leptin receptor (Ob-R) in human atherosclerotic lesions: potential role in intimal neovascularization

Kang SM, Kwon HM, Hong BK, Kim D, Kim IJ, Choi EY, Jang Y, Kim HS, Kim MS, Kwon HC

Neovascularization of the adventitial vasa vasorum with extension into the intima of atherosclerotic lesions is frequently observed, but its pathophysiological significance is still subject to debate. Recently, leptin, the product...
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Expression of osteopontin in calcified coronary atherosclerotic plaques

Kwon HM, Hong BK, Kang TS, Kwon K, Kim HK, Jang Y, Choi D, Park HY, Kang SM, Cho SY, Kim HS

Advanced atherosclerosis is often associated with dystrophic calcification and remodeling of extracellular matrix of vascular wall. Recently many studies have documented a general relationship between calcification and severity of coronary...
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Serologic and histopathologic study of Chlamydia pneumoniae infection in atherosclerosis: a possible pathogenetic mechanism of atherosclerosis induced by Chlamydia pneumoniae

Song YG, Kwon HM, Kim JM, Hong BK, Kim DS, Huh AJ, Chang KH, Kim HY, Kang TS, Lee BK, Choi DH, Jang YS, Kim HS

Chronic infection and inflammation have recently been implicated as important etiologic agents for atherosclerosis in general and, in particular, ischemic heart disease. Several agents have been suggested as possible candidates...
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Hypoxic Regulation of VEGF, HIF-1 (alpha) in Coronary Collaterals Development

Sung KC, Kim KS, Lee S

BACKGROUND: The interindividual variability for the development of collaterals in coronary artery disease is dependent on the hypoxic induction level of VEGF. To determine whether the hypoxic induction of VEGF...
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Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro

Park HY, Kwon HM, Lim HJ, Hong BK, Lee JY, Park BE, Jang YS, Cho SY, Kim HS

  • KMID: 1085746
  • Exp Mol Med.
  • 2001 Jun;33(2):95-102.
Leptin, the product of ob gene, is an endocrine hormone that regulates adipose tissue mass. Recently, leptin has been found to generate a growth signal involving a tyrosine kinase-dependent intracellular...
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