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Curcumin supplementation shows modulatory influence on functional and morphological features of hippocampus in mice subjected to arsenic trioxide exposure

Mehta K, Kaur B, Pandey KK, Kaler S, Dhar P

Since, oxidative stress has been suggested as one of the mechanisms underlying arsenic-induced toxicity, the present study focused on the role of antioxidant (curcumin) supplementation on behavioral, biochemical, and morphological...
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Src Family Kinase Inhibitor PP2 Has Different Effects on All-Trans-Retinoic Acid or Arsenic Trioxide-Induced Differentiation of an Acute Promyelocytic Leukemia Cell Line

Yoon SG, Cheong HJ, Kim SJ, Kim KH, Lee SC, Lee N, Park HS, Won JH

  • KMID: 2167618
  • Cancer Res Treat.
  • 2013 Jun;45(2):126-133.
PURPOSE: Leukemic promyelocytes have the unique ability to undergo differentiation after exposure to retinoic acid and both differentiation and apoptosis after exposure to arsenic trioxide (ATO). Recent studies have shown...
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Arsenic trioxide induces depolymerization of microtubules in an acute promyelocytic leukemia cell line

Baek JH, Moon CH, Cha SJ, Lee HS, Noh EK, Kim H, Won JH, Min YJ

BACKGROUND: Arsenic trioxide (As2O3) is a well-known and effective treatment that can result in clinical remission for patients diagnosed with acute promyelocytic leukemia (APL). The biologic efficacy of As2O3 in...
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Effects of Arsenic Trioxide on Radiofrequency Ablation of VX2 Liver Tumor: Intraarterial versus Intravenous Administration

Seong NJ, Yoon CJ, Kang SG, Chung JW, Kim HC, Park JH

OBJECTIVE: Arsenic trioxide (As2O3) can be used as a possible pharmaceutical alternative that augments radiofrequency (RF) ablation by reducing tumor blood flow. The aim of this study was to assess...
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Recent advances in the diagnosis and management of childhood acute promyelocytic leukemia

Yoo ES

Since the successful introduction of all-trans-retinoic acid (ATRA) and its combination with anthracycline-containing chemotherapy, the prognosis for acute promyelocytic leukemia (APL) has markedly improved. With ATRA and anthracycline-based-chemotherapy, the complete...
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Central Nervous System Relapse in Patients with Acute Promyelocytic Leukemia Treated with All-trans Retinoic Acid

Kim EO, Gil SH, Choi JK, Lee HJ, Kim HJ, Lee JW, Min WS

  • KMID: 1966888
  • Korean J Med.
  • 2011 Feb;80(2):231-237.
Acute promyelocytic leukemia (APL) is distinguished from other subtypes of acute myeloid leukemia (AML) by its distinctive morphology, specific chromosomal abnormality, coagulopathy, and unique response to treatment with all-trans retinoic...
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Induction of hypoxia-inducible factor-1alpha inhibits drug-induced apoptosis in the human leukemic cell line HL-60

Yook YJ, Seo YJ, Kang HJ, Ko SH, Shin HY, Lee JJ, Jeong G, Ahn HS

BACKGROUND: Leukemic cells originate from hypoxic bone marrow, which protects them from anti-cancer drugs. Although many factors that cause drug resistance in leukemic cells have been studied, the effect of...
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Inhibition of cell growth and apoptosis in CaSki, cervical cancer cell line by arsenic compounds

Byun JM, Jeong DH, Lee DS, Kim JR, Kim YN, Jeong EJ, Sung MS, Lee KB, Kim KT

OBJECTIVE: To compare inhibition of cell growth and apoptosis in human cervical cancer cell lines (CaSki) by paclitaxel, cisplatin, arsenic trioxide and tetraarsenic oxide. METHODS: Inhibition of cell growth was determined...
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Salvage treatments with all-trans retinoic acid and arsenic trioxide-based regimens in acute promyelocytic leukemia

Cho YY, Kim JG, Chae YS, Moon JH, Ahn BM, Sohn SK

  • KMID: 2256190
  • Korean J Med.
  • 2008 Jun;74(6):596-604.
BACKGROUND/AIMS: Acute promyelocytic leukemia is a distinct subtype of acute myeloid leukemia with a specific clinical and molecular presentation. Treatment of acute promyelocytic leukemia with all-trans retinoic acid or arsenic...
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Remission induction using arsenic trioxide in acute promyelocytic leukemia

Min CK

  • KMID: 2256189
  • Korean J Med.
  • 2008 Jun;74(6):593-595.
In acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA) triggers cell differentiation, while arsenic trioxide (ATO) generates partial differentiation and apoptosis. Standard initial treatment for patients with APL consists of...
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Osteomyelitis on Maxilla Caused by Arsenic Trioxide

Choi BY, Yoo DH, Choi MK, Choi JG, Lee YJ, Jo BH

  • KMID: 1485195
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2008 Nov;30(6):593-598.
Arsenic trioxide is one of the 'tooth pulp devitalizing agents' used through the dental history when anaesthesia was not available. But owing to its capacity to kill cells in surrounding...
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Enhancement of Arsenic Trioxide (As2O3)-Mediated Apoptosis Using Berberine in Human Neuroblastoma SH-SY5Y Cells

Kim DW, Ahan SH, Kim TY

OBJECTIVE: Arsenic trioxide (As2O3) has been used as an anticancer agent in traditional Chinese medicine for thousand years and berberine is an isoquinoline alkaloid present that has indicated significant antimicrobial...
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Arsenic Trioxide Induces A poptosis in Human Colorectal Adenocarcinoma HT-29 Cells Through ROS

Cha Y, Park DW, Lee CH, Baek SH, Kim SY, Kim JR, Kim JH

  • KMID: 2166094
  • Cancer Res Treat.
  • 2006 Feb;38(1):54-60.
PURPOSE: Treatment with arsenic trioxide (As2O3) results in a wide range of cellular effects that includes induction of apoptosis, inhibition of cell growth, promotion or inhibition of cellular differentiation, and...
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Combination Treatment with Arsenic Trioxide and Sulindac Induces Apoptosis of NCI-H157 Human Lung Carcinoma Cells via ROS Generation with Mitochondrial Dysfunction

Kim HR, Yang SH, Jeong ET

  • KMID: 2318635
  • Tuberc Respir Dis.
  • 2005 Jul;59(1):30-38.
BACKGROUND: Arsenic trioxide (As2O3) has been used to treat acute promyelocytic leukemia, and it induces apoptosis in a variety of solid tumor cell lines including non-small cell lung cancer cells....
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Arsenic Trioxide Induces Erythroid Differentiation and Apoptosis of K562 Human Leukemia Cells through the Down-Regulation of Bcl-2

You YK, Cheong HJ, Won JH, Kim SJ, Bae SB, Kim CK, Lee NS, Lee KT, Park SK, Hong DS, Park HS

BACKGROUND: Arsenic trioxide (As2O3) has been identified as an effective drug for the treatment of acute promyelocytic leukemia (APL). However, the role of As2O3 during the erythroid differentiation of human...
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Synergistic Cytotoxicity of Arsenic Trioxide and Sulindac Against Neuroblastoma

Choi DY

  • KMID: 1314295
  • Korean J Pediatr.
  • 2004 Sep;47(9):1002-1007.
PURPOSE: Recent clinical studies have shown that arsenic trioxide(As2O3) at low concentrations induces complete remission without significant toxicity in patients with refractory acute promyelocytic leukemia(APL). Like APL cells, neuroblastoma(NB) cells...
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Inducing Apoptosis of NCI-H157 Human Lung Carcinoma Cells via Activation of Caspase Cascade by Combination Treatment with Arsenic Trioxide and Sulindac

Kim HR, Yang SH, Jeong ET

  • KMID: 2318477
  • Tuberc Respir Dis.
  • 2004 Apr;56(4):381-392.
Arsenic trioxide(As2O3) was introduced into the treatment of refractory or relapsed acute promyelocytic leukemia. Some investigators have reported that arsenic trioxide had induced apoptosis in a variety of solid human...
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Antitumor Effects of Arsenic Trioxide on Neuroblastoma

Ryu KH, Woo SY, Seoh JY, Kim CJ, Shin HY, Ahn HS

  • KMID: 2278269
  • Korean J Pediatr Hematol Oncol.
  • 2003 Apr;10(1):64-71.
PURPOSE: We aimed to study the feasibility of arsenic trioxide as a treatment of neuroblastoma which has the ability to differentiate into nonmalignant cells like acute promyelocytic leukemia. METHODS: To...
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Effect of Arsenic Trioxide in TRAIL (Tumor Necrosis Factor-related Apoptosis Inducing Ligand)-Mediated Apoptosis in Multiple Myeloma Cell Lines

Byun JH, Hong YS, Cheong HJ, Kim SJ, Lee NS, Won JH, Hong DS, Park HS

  • KMID: 1972866
  • Cancer Res Treat.
  • 2003 Dec;35(6):472-477.
PURPOSE: The potential therapeutic application of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), in the treatment of multiple myeloma (MM), was recently proposed. However, there have been some problems with...
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Arsenic Trioxide Induces Apoptosis of HL-60 Cells via Activation of Intrinsic Caspase Protease with Mitochondrial Dysfunction

Jung BH, Park C, Kim HR, Park MR

  • KMID: 1804473
  • Cancer Res Treat.
  • 2002 Aug;34(4):308-315.
Arsenic trioxide (As2O3) was introduced into the treatment of refractory or relapsed acute promyelocytic leukemia and showed a striking effectiveness in China and United States multicenter study. However, the mechanistic...
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