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Long-term control of refractory follicular lymphoma after treatment of secondary acute promyelocytic leukemia with arsenic trioxide (As₂O₃) and all-trans retinoic acid (ATRA)

Jain P, Konoplev S, Benjamini , Romagura J, Burger JA

No abstract available.
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Squamous Cell Carcinoma Associated with Arsenic Keratosis in a Psoriasis Patient Treated with Ustekinumab: A Case Report

Jung SY

  • KMID: 2391166
  • Korean J Dermatol.
  • 2017 Aug;55(7):440-444.
A 53-year-old Korean woman with known history of psoriasis and treatment with ustekinumab over 16 months, presented with a nontender erythematous plaque with oozing noted on her left sole. Histopathologic...
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Urinary arsenic species concentration in residents living near abandoned metal mines in South Korea

Chung JY, Kim BG, Lee BK, Moon JD, Sakong J, Jeon MJ, Park JD, Choi BS, Kim NS, Yu SD, Seo JW, Ye BJ, Lim HJ, Hong YS

BACKGROUND: Arsenic is a carcinogenic heavy metal that has a species-dependent health effects and abandoned metal mines are a source of significant arsenic exposure. Therefore, the aims of this study...
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Protective effect of resveratrol on arsenic trioxide-induced nephrotoxicity in rats

Zhang W, Liu Y, Ge M, Jing J, Chen Y, Jiang H, Yu H, Li N, Zhang Z

  • KMID: 2313733
  • Nutr Res Pract.
  • 2014 Apr;8(2):220-226.
BACKGROUD/OBEJECTIVES: Arsenic, which causes human carcinogenicity, is ubiquitous in the environment. This study was designed to evaluate modulation of arsenic induced cancer by resveratrol, a phytoalexin found in vegetal dietary...
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The separation of arsenic metabolites in urine by high performance liquid chromatographyinductively coupled plasma-mass spectrometry

Chung JY, Lim HJ, Kim YJ, Song KH, Kim BG, Hong YS

OBJECTIVES: The purpose of this study was to determine a separation method for each arsenic metabolite in urine by using a high performance liquid chromatography (HPLC)- inductively coupled plasma-mass spectrometer...
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Assessment of Arsenic Exposure by Measurement of Urinary Speciated Inorganic Arsenic Metabolites in Workers in a Semiconductor Manufacturing Plant

Byun K, Won YL, Hwang YI, Koh DH, Im H, Kim EA

  • KMID: 2379967
  • Ann Occup Environ Med.
  • 2013 ;25(1):21.
OBJECTIVES: The purpose of this study was to evaluate the exposure to arsenic in preventive maintenance (PM) engineers in a semiconductor industry by detecting speciated inorganic arsenic metabolites in the...
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Association of Diabetes Mellitus with a Combination of Vitamin D Deficiency and Arsenic Exposure in the Korean General Population: Analysis of 2008-2009 Korean National Health and Nutrition Examination Survey Data

Lee BK, Kim Y

  • KMID: 2379953
  • Ann Occup Environ Med.
  • 2013 ;25(1):7.
OBJECTIVES: We present data from the Korean National Health and Nutritional Examination Survey (KNHANES) 2008-2009 on the combination of vitamin D deficiency and arsenic exposure on diabetes mellitus (DM) in...
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Enhancement of Arsenic Trioxide (As2O3)-Mediated Apoptosis Using Berberine in Human Neuroblastoma SH-SY5Y Cells

Kim DW, Ahan SH, Kim TY

OBJECTIVE: Arsenic trioxide (As2O3) has been used as an anticancer agent in traditional Chinese medicine for thousand years and berberine is an isoquinoline alkaloid present that has indicated significant antimicrobial...
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Arsenic Trioxide Induces A poptosis in Human Colorectal Adenocarcinoma HT-29 Cells Through ROS

Cha Y, Park DW, Lee CH, Baek SH, Kim SY, Kim JR, Kim JH

  • KMID: 2166094
  • Cancer Res Treat.
  • 2006 Feb;38(1):54-60.
PURPOSE: Treatment with arsenic trioxide (As2O3) results in a wide range of cellular effects that includes induction of apoptosis, inhibition of cell growth, promotion or inhibition of cellular differentiation, and...
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Combination Treatment with Arsenic Trioxide and Sulindac Induces Apoptosis of NCI-H157 Human Lung Carcinoma Cells via ROS Generation with Mitochondrial Dysfunction

Kim HR, Yang SH, Jeong ET

  • KMID: 2318635
  • Tuberc Respir Dis.
  • 2005 Jul;59(1):30-38.
BACKGROUND: Arsenic trioxide (As2O3) has been used to treat acute promyelocytic leukemia, and it induces apoptosis in a variety of solid tumor cell lines including non-small cell lung cancer cells....
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A fatal case of acute arsenic poisoning

Wi HS, Lee SH, Seo YH, Kim JG, Kim GC, Jang CS, Roh HK

  • KMID: 1984650
  • Korean J Med.
  • 2005 Jul;69(1):101-106.
Arsenic trioxide is the most prevalent natural inorganic form of arsenic, which is a widely used heavy metal and is ubiquitously distributed in the environment. A 71-year-old man ingested about...
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Arsenic Trioxide Induces Erythroid Differentiation and Apoptosis of K562 Human Leukemia Cells through the Down-Regulation of Bcl-2

You YK, Cheong HJ, Won JH, Kim SJ, Bae SB, Kim CK, Lee NS, Lee KT, Park SK, Hong DS, Park HS

BACKGROUND: Arsenic trioxide (As2O3) has been identified as an effective drug for the treatment of acute promyelocytic leukemia (APL). However, the role of As2O3 during the erythroid differentiation of human...
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Inducing Apoptosis of NCI-H157 Human Lung Carcinoma Cells via Activation of Caspase Cascade by Combination Treatment with Arsenic Trioxide and Sulindac

Kim HR, Yang SH, Jeong ET

  • KMID: 2318477
  • Tuberc Respir Dis.
  • 2004 Apr;56(4):381-392.
Arsenic trioxide(As2O3) was introduced into the treatment of refractory or relapsed acute promyelocytic leukemia. Some investigators have reported that arsenic trioxide had induced apoptosis in a variety of solid human...
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Antitumor Effects of Arsenic Trioxide on Neuroblastoma

Ryu KH, Woo SY, Seoh JY, Kim CJ, Shin HY, Ahn HS

  • KMID: 2278269
  • Korean J Pediatr Hematol Oncol.
  • 2003 Apr;10(1):64-71.
PURPOSE: We aimed to study the feasibility of arsenic trioxide as a treatment of neuroblastoma which has the ability to differentiate into nonmalignant cells like acute promyelocytic leukemia. METHODS: To...
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Acute Toxicity of Arsenic in Rats and Mice

Choi BS, Kang DW, Lee JY, Park ES, Hong YP, Yang JS, Lee H, Park JD

  • KMID: 2141557
  • Korean J Occup Environ Med.
  • 2003 Dec;15(4):323-334.
OBJECTIVES: Arsenic (As) is ubiquitously distributed in the environment and is known as a human carcinogen. In this study, acute As toxicity at lethal dosage in rats and mice was...
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Effect of Arsenic Trioxide in TRAIL (Tumor Necrosis Factor-related Apoptosis Inducing Ligand)-Mediated Apoptosis in Multiple Myeloma Cell Lines

Byun JH, Hong YS, Cheong HJ, Kim SJ, Lee NS, Won JH, Hong DS, Park HS

  • KMID: 1972866
  • Cancer Res Treat.
  • 2003 Dec;35(6):472-477.
PURPOSE: The potential therapeutic application of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), in the treatment of multiple myeloma (MM), was recently proposed. However, there have been some problems with...
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Arsenic Trioxide, an Old Drug? or a New Drug?

Rhee CH

  • KMID: 1972864
  • Cancer Res Treat.
  • 2003 Dec;35(6):465-466.
No abstract available.
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Arsenic Trioxide Induces Apoptosis of HL-60 Cells via Activation of Intrinsic Caspase Protease with Mitochondrial Dysfunction

Jung BH, Park C, Kim HR, Park MR

  • KMID: 1804473
  • Cancer Res Treat.
  • 2002 Aug;34(4):308-315.
Arsenic trioxide (As2O3) was introduced into the treatment of refractory or relapsed acute promyelocytic leukemia and showed a striking effectiveness in China and United States multicenter study. However, the mechanistic...
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Remission Induction by Arsenic Trioxide in Patient with Relapsed Acute Promyelocytic Leukemia after Allogeneic Bone Marrow Transplantation

Song HJ, Lee NS, Kim SE, Kim CK, Lee GT, Park SG, Won JH, Baick SH, Hong DS, Park HS

  • KMID: 1641959
  • Korean J Hematol.
  • 2002 Aug;37(3):218-222.
All-trans retinoic acid (ATRA) therapy induces complete remission in acute promyelocytic leukemia (APL) via differentiation of the APL cells. Recent clinical trials in China and United states showed that arsenic...
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Arsenic Trioxide (As2O3) Induced Apoptosis in NB4 Cell lines

Park KB, Hong DS, Suh WS, Lee NS, Park SG, Won JH, Jung HJ, Kim SJ, Hong YS, Jin JY, Park HS, Shin SM

  • KMID: 1641957
  • Korean J Hematol.
  • 2002 Aug;37(3):200-211.
BACKGROUND: Recently, inorganic arsenic trioxide (As2O3) was reported to induce complete remission in a high proportion of patients with refractory acute promyelocytic leukemia (APL). To illustrate cellular and molecular mechanisms...
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